Foods for Signet Ring Cell Type Of The Appendix!

Introduction

Foods for Signet Ring Cell Type Of The Appendix should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Signet Ring Cell Type Of The Appendix does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Signet Ring Cell Type Of The Appendix does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Signet Ring Cell Type Of The Appendix?

For example does it matter if vegetable Cauliflower is consumed more compared to Carob? Does it make any difference if fruit Mammee Apple is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Common Walnut over European Chestnut and for pulses like Gram Bean over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Signet Ring Cell Type Of The Appendix and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Signet Ring Cell Type Of The Appendix!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Mammee Apple contains active ingredients Caffeine, Curcumin, Lycopene, Phloretin, Apigenin. And Pomegranate contains active ingredients Curcumin, Quercetin, Phloretin, Apigenin, Beta-sitosterol and possibly others.

A common mistake made when deciding and choosing foods to eat for Signet Ring Cell Type Of The Appendix – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Signet Ring Cell Type Of The Appendix.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Signet Ring Cell Type Of The Appendix?

Personalized nutrition for cancers like Signet Ring Cell Type Of The Appendix consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Signet Ring Cell Type Of The Appendix biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Signet Ring Cell Type Of The Appendix

All cancers like Signet Ring Cell Type Of The Appendix can be characterized by a unique set of biochemical pathways – the signature pathways of Signet Ring Cell Type Of The Appendix. Biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition, MAPK Signaling, Cell Cycle Checkpoints are part of the signature definition of Signet Ring Cell Type Of The Appendix. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Signet Ring Cell Type Of The Appendix need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Signet Ring Cell Type Of The Appendix when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ATM, EPHA5, ERBB4, GNAS and MAP2K4 are the top ranked reported genes for Signet Ring Cell Type Of The Appendix. ATM is reported in 25.0 % of the representative patients across all clinical trials. And EPHA5 is reported in 25.0 %. The combined population patient data cover ages from to . 25.0 % of the patient data are identified as men. The Signet Ring Cell Type Of The Appendix biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Signet Ring Cell Type Of The Appendix

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or CAROB?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Phloretin, Beta-sitosterol, Brassinin, Eugenol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Carob are Curcumin, Quercetin, Phloretin, Apigenin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair and Epithelial to Mesenchymal Transition and others. Carob is not recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER CAROB FOR Signet Ring Cell Type Of The Appendix AND TREATMENT Radiation.

Choose Fruit POMEGRANATE or MAMMEE APPLE?

Fruit Pomegranate contains many active ingredients or bioactives such as Curcumin, Quercetin, Phloretin, Apigenin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Pomegranate is recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Mammee Apple are Caffeine, Curcumin, Lycopene, Phloretin, Apigenin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Mammee Apple is not recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER MAMMEE APPLE FOR Signet Ring Cell Type Of The Appendix AND TREATMENT Radiation.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Phloretin, Beta-sitosterol, Beta-carotene. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and MYC Signaling and others. Common Walnut is recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Quercetin, Phloretin, Apigenin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Signet Ring Cell Type Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Signet Ring Cell Type Of The Appendix AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Signet Ring Cell Type Of The Appendix or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CUCURBITA?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair, P53 Signaling, Growth Factor Signaling and MAPK Signaling and others. Giant Butterbur is recommended for risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cucurbita are Curcumin, Protocatechuic Acid, Delphinidin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and MAPK Signaling and others. Cucurbita is not recommended when risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CUCURBITA FOR ATM GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Protocatechuic Acid, Delphinidin, Quercetin. These active ingredients manipulate various biochemical pathways like DNA Repair, P53 Signaling, Growth Factor Signaling and MAPK Signaling and others. Red Raspberry is recommended for risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair and MAPK Signaling and others. Pummelo is not recommended when risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR ATM GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lycopene, Protocatechuic Acid, Delphinidin, Quercetin. These active ingredients manipulate various biochemical pathways like DNA Repair, P53 Signaling, MAPK Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Curcumin, Apigenin, Protocatechuic Acid, Delphinidin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Signet Ring Cell Type Of The Appendix when associated genetic risk is ATM because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR ATM GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Signet Ring Cell Type Of The Appendix. Signet Ring Cell Type Of The Appendix patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Signet Ring Cell Type Of The Appendix, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Signet Ring Cell Type Of The Appendix?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
• Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Perturbation of the EphA2-EphrinA1 system in human prostate cancer cells by colonic (poly)phenol catabolites.
• The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation.
• Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.