Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Signet Ring Cell Type Of The Appendix when undergoing chemotherapy or when you determine you have a genetic risk for developing Signet Ring Cell Type Of The Appendix because of ATM and EPHA5 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Signet Ring Cell Type Of The Appendix which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Malus (crab Apple)” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Diosmin and Lemon Verbena supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SIGNET RING CELL TYPE OF THE APPENDIX, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Signet Ring Cell Type Of The Appendix is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SIGNET RING CELL TYPE OF THE APPENDIX, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Signet Ring Cell Type Of The Appendix
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Signet Ring Cell Type Of The Appendix from cBioPortal. 25.0% of males and 75.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Signet Ring Cell Type Of The Appendix include genes ATM, EPHA5, ERBB4, GNAS and MAP2K4. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Signet Ring Cell Type Of The Appendix are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Signet Ring Cell Type Of The Appendix.
Significance of Nutrition for Signet Ring Cell Type Of The Appendix
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Signet Ring Cell Type Of The Appendix. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Malus (crab Apple) includes active ingredients Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others. And Pomegranate contains active ingredients Betulinic Acid, Beta-sitosterol, Corilagin, Vitamin C, Apigenin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Signet Ring Cell Type Of The Appendix, activation or inhibition of selected biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition, MAPK Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Signet Ring Cell Type Of The Appendix, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SIGNET RING CELL TYPE OF THE APPENDIX – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Signet Ring Cell Type Of The Appendix undergoing chemotherapy treatment
In Signet Ring Cell Type Of The Appendix – the genes ATM, EPHA5, ERBB4, GNAS and MAP2K4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Signet Ring Cell Type Of The Appendix are DNA Repair, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Beta-carotene, Vitamin C, Daidzein, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Common Bean are Vitamin C, Apigenin, Esculin, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Daidzein has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition and DNA Repair. Esculin has biological action on biochemical pathways DNA Repair. And so on.
When treating Signet Ring Cell Type Of The Appendix with chemotherapy Radiation – Foods like Black-eyed Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Daidzein contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER COMMON BEAN FOR SIGNET RING CELL TYPE OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Rhubarb?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Vitamin C, Protocatechuic Acid, Chlorogenic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Rhein, Vitamin C, Emodin, Gallic Acid and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and MYC Signaling. Beta-carotene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and DNA Repair.
Rhein can manipulate biochemical pathways DNA Repair. Emodin has biological action on biochemical pathways DNA Repair. And so on.
When treating Signet Ring Cell Type Of The Appendix with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Rhubarb. This is because the active ingredients Rhein and Emodin in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER RHUBARB FOR SIGNET RING CELL TYPE OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Malus (crab Apple)?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Betulinic Acid, Beta-sitosterol, Corilagin, Vitamin C, Apigenin among others. While the active ingredients contained in Malus (crab Apple) are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, Epithelial to Mesenchymal Transition and MYC Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Signet Ring Cell Type Of The Appendix with chemotherapy Radiation – Foods like Pomegranate are recommended compared to Malus (crab Apple). This is because the active ingredients Oleic Acid and Linoleic Acid in Malus (crab Apple) interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR SIGNET RING CELL TYPE OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin E, Oleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Vitamin C, Gallic Acid, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, Epithelial to Mesenchymal Transition and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Signet Ring Cell Type Of The Appendix with chemotherapy Radiation – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR SIGNET RING CELL TYPE OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Signet Ring Cell Type Of The Appendix
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ATM and EPHA5 are two genes whose abnormalities are risk factors for Signet Ring Cell Type Of The Appendix. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Signet Ring Cell Type Of The Appendix can be used as a guide for coming up with a recommended personalized nutrition plan. For Signet Ring Cell Type Of The Appendix gene ATM has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And EPHA5 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ATM and EPHA5 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ATM and EPHA5 should be avoided.
Eat more pulses, Scarlet Bean or Lima Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Apoptosis.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Signet Ring Cell Type Of The Appendix due to abnormalities in genes ATM and EPHA5 – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL TYPE OF THE APPENDIX DUE TO GENES ATM AND EPHA5
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Oleic Acid, Linolenic Acid, Cynaroside and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling and DNA Repair. And so on.
For genetic risk of Signet Ring Cell Type Of The Appendix due to abnormalities in genes ATM and EPHA5 – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL TYPE OF THE APPENDIX DUE TO GENES ATM AND EPHA5
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Partridgeberry or Strawberry?
The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Strawberry are Lupeol, Beta-sitosterol, Vitamin C, Ellagic Acid, Oleic Acid and others.
Resveratrol can manipulate biochemical pathways Apoptosis, DNA Repair and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Fisetin can manipulate biochemical pathways MYC Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Signet Ring Cell Type Of The Appendix due to abnormalities in genes ATM and EPHA5 – Foods like Partridgeberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL TYPE OF THE APPENDIX DUE TO GENES ATM AND EPHA5
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Quercetin has biological action on biochemical pathways EPHRIN Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Signet Ring Cell Type Of The Appendix due to abnormalities in genes ATM and EPHA5 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL TYPE OF THE APPENDIX DUE TO GENES ATM AND EPHA5
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Signet Ring Cell Type Of The Appendix by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.