Which Foods are Recommended for Sclerosing Epithelioid Fibrosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sclerosing Epithelioid Fibrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Sclerosing Epithelioid Fibrosarcoma because of PBRM1 and TGFBR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Sclerosing Epithelioid Fibrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Sweet Potato” or “Can I take Naringenin and Diosmin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SCLEROSING EPITHELIOID FIBROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Sclerosing Epithelioid Fibrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SCLEROSING EPITHELIOID FIBROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Sclerosing Epithelioid Fibrosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Sclerosing Epithelioid Fibrosarcoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 14; the top genes with mutations and other abnormalities for Sclerosing Epithelioid Fibrosarcoma include genes PBRM1, TGFBR2, ATRX, BCOR and KMT2A. The occurrence frequency distribution for these genes respectively is 25.0%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Sclerosing Epithelioid Fibrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sclerosing Epithelioid Fibrosarcoma.

Significance of Nutrition for Sclerosing Epithelioid Fibrosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sclerosing Epithelioid Fibrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Modified Citrus Pectin, Linoleic Acid, Caffeic Acid, Vitamin A and others. And Blackberry contains active ingredients Ellagic Acid, Salicylic Acid, Quercetin, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Sclerosing Epithelioid Fibrosarcoma, activation or inhibition of selected biochemical pathways like TGFB Signaling, Cytokine Signaling, Hypoxia, Energy Metabolism plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sclerosing Epithelioid Fibrosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SCLEROSING EPITHELIOID FIBROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Sclerosing Epithelioid Fibrosarcoma undergoing chemotherapy treatment

In Sclerosing Epithelioid Fibrosarcoma – the genes PBRM1, TGFBR2, ATRX, BCOR and KMT2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sclerosing Epithelioid Fibrosarcoma are TGFB Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers TGFB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Lentils or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Lentils are Ellagic Acid, Isoliquiritigenin, Linoleic Acid, Esculin, Vitamin A among others. While the active ingredients contained in Lima Bean are Linoleic Acid, Vitamin A and others.

Ellagic Acid can manipulate biochemical pathways TGFB Signaling. Isoliquiritigenin has biological action on biochemical pathways TGFB Signaling.

Vitamin A can manipulate biochemical pathways TGFB Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Sclerosing Epithelioid Fibrosarcoma with chemotherapy Radiation – Foods like Lentils are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Isoliquiritigenin contained in Lentils support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER LIMA BEAN FOR SCLEROSING EPITHELIOID FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Sweet Potato?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Pelargonidin, Quercetin, Indole-3-carbinol among others. While the active ingredients contained in Sweet Potato are Salicylic Acid, Quercetin, Linoleic Acid, Vitamin A and others.

Pelargonidin can manipulate biochemical pathways TGFB Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling.

Vitamin A can manipulate biochemical pathways TGFB Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Sclerosing Epithelioid Fibrosarcoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Sweet Potato. This is because the active ingredients Vitamin A and Linoleic Acid in Sweet Potato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Pelargonidin and Quercetin contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SWEET POTATO FOR SCLEROSING EPITHELIOID FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Blackberry or Peach?

Fruits are an important part of many diets. The active ingredients contained in Blackberry are Ellagic Acid, Salicylic Acid, Quercetin, Gallic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Linoleic Acid, Caffeic Acid, Vitamin A and others.

Ellagic Acid can manipulate biochemical pathways TGFB Signaling. Salicylic Acid has biological action on biochemical pathways TGFB Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Sclerosing Epithelioid Fibrosarcoma with chemotherapy Radiation – Foods like Blackberry are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Vitamin A in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Salicylic Acid contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER PEACH FOR SCLEROSING EPITHELIOID FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Almond or Pistachio?

Nuts are an important part of many diets. The active ingredients contained in Almond are Salicylic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Pistachio are Linoleic Acid, Vitamin A and others.

Salicylic Acid can manipulate biochemical pathways TGFB Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling.

Vitamin A can manipulate biochemical pathways TGFB Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Sclerosing Epithelioid Fibrosarcoma with chemotherapy Radiation – Foods like Almond are recommended compared to Pistachio. This is because the active ingredients Vitamin A and Linoleic Acid in Pistachio interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Salicylic Acid and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PISTACHIO FOR SCLEROSING EPITHELIOID FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Sclerosing Epithelioid Fibrosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PBRM1 and TGFBR2 are two genes whose abnormalities are risk factors for Sclerosing Epithelioid Fibrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sclerosing Epithelioid Fibrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Sclerosing Epithelioid Fibrosarcoma gene PBRM1 has causative impact on biological pathways like Chromatin Remodeling. And TGFBR2 has a causative impact on biological pathways like TGFB Signaling, Extracellular Matrix Remodelling and Inflammation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PBRM1 and TGFBR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PBRM1 and TGFBR2 should be avoided.

Eat more pulses, Winged Bean or Yellow Wax Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Cianidanol, Butyric Acid, Astragalin and others.

Betulinic Acid can manipulate biochemical pathways Cell Cycle, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Palmitic Acid can manipulate biochemical pathways TGFB Signaling, Cell Cycle and MAPK Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling and TGFB Signaling. And so on.

For genetic risk of Sclerosing Epithelioid Fibrosarcoma due to abnormalities in genes PBRM1 and TGFBR2 – Foods like Winged Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Vitamin A in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF SCLEROSING EPITHELIOID FIBROSARCOMA DUE TO GENES PBRM1 AND TGFBR2

Eat more vegetables, Jicama or Garden Cress?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Garden Cress are Vitamin E, Benzyl Isothiocyanate, Isorhamnetin, Beta-sitosterol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways Hypoxia, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

For genetic risk of Sclerosing Epithelioid Fibrosarcoma due to abnormalities in genes PBRM1 and TGFBR2 – Foods like Jicama are recommended compared to Garden Cress. This is because the active ingredients Vitamin A and Linoleic Acid in Garden Cress further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER GARDEN CRESS FOR REDUCING THE GENETIC RISK OF SCLEROSING EPITHELIOID FIBROSARCOMA DUE TO GENES PBRM1 AND TGFBR2

Eat more fruits, Jujube or Naranjilla?

The active ingredients contained in Jujube are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.

For genetic risk of Sclerosing Epithelioid Fibrosarcoma due to abnormalities in genes PBRM1 and TGFBR2 – Foods like Jujube are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Jujube together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JUJUBE IS RECOMMENDED OVER NARANJILLA FOR REDUCING THE GENETIC RISK OF SCLEROSING EPITHELIOID FIBROSARCOMA DUE TO GENES PBRM1 AND TGFBR2

Eat more nuts, Pine Nut or Macadamia Nut?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Cell Cycle. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Palmitic Acid can manipulate biochemical pathways TGFB Signaling, Cell Cycle and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

For genetic risk of Sclerosing Epithelioid Fibrosarcoma due to abnormalities in genes PBRM1 and TGFBR2 – Foods like Pine Nut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF SCLEROSING EPITHELIOID FIBROSARCOMA DUE TO GENES PBRM1 AND TGFBR2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Sclerosing Epithelioid Fibrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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