Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pulmonary Artery Intimal Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pulmonary Artery Intimal Sarcoma because of PDGFRB and NFKBIA gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Pulmonary Artery Intimal Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Pitanga in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Spirulina and Beta-carotene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PULMONARY ARTERY INTIMAL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Pulmonary Artery Intimal Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PULMONARY ARTERY INTIMAL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Pulmonary Artery Intimal Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Pulmonary Artery Intimal Sarcoma from cBioPortal. 29.6% of males and 70.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Pulmonary Artery Intimal Sarcoma include genes PDGFRB, NFKBIA, BARD1, TP53 and CDKN1A. The occurrence frequency distribution for these genes respectively is 11.8%, 5.9%, 5.9%, 5.9% and 5.9%. These tumor genetic details of Pulmonary Artery Intimal Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pulmonary Artery Intimal Sarcoma.
Significance of Nutrition for Pulmonary Artery Intimal Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pulmonary Artery Intimal Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Hyperoside, P-coumaric Acid, Quercitrin, Vitamin C and others. And Pitanga contains active ingredients Quercetin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Pulmonary Artery Intimal Sarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, DNA Repair, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pulmonary Artery Intimal Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PULMONARY ARTERY INTIMAL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Pulmonary Artery Intimal Sarcoma undergoing chemotherapy treatment
In Pulmonary Artery Intimal Sarcoma – the genes PDGFRB, NFKBIA, BARD1, TP53 and CDKN1A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pulmonary Artery Intimal Sarcoma are Cell Cycle Checkpoints, Apoptosis, Growth Factor Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Linolenic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Quercetin, Daidzein, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Pulmonary Artery Intimal Sarcoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Genistein and Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR PULMONARY ARTERY INTIMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Beta-carotene, Quercetin, Vitamin C, Protocatechuic Acid, Chlorogenic Acid among others. While the active ingredients contained in Radish are Quercetin, P-coumaric Acid, Linolenic Acid, Beta-sitosterol, Vitamin C and others.
Beta-carotene can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Growth Factor Signaling and MYC Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways DNA Repair. And so on.
When treating Pulmonary Artery Intimal Sarcoma with chemotherapy Doxorubicin – Foods like Arrowroot are recommended compared to Radish. This is because the active ingredients Pelargonidin and Vitamin B3 in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Quercetin contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER RADISH FOR PULMONARY ARTERY INTIMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Pitanga or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Pitanga are Quercetin, Vitamin C, Vitamin A among others. While the active ingredients contained in Cranberry are Quercetin, Hyperoside, P-coumaric Acid, Quercitrin, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.
When treating Pulmonary Artery Intimal Sarcoma with chemotherapy Doxorubicin – Foods like Pitanga are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Pitanga support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PITANGA IS RECOMMENDED OVER CRANBERRY FOR PULMONARY ARTERY INTIMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Beta-sitosterol, Linolenic Acid, Ferulic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and JAK-STAT Signaling. Vitamin B3 has biological action on biochemical pathways DNA Repair. And so on.
When treating Pulmonary Artery Intimal Sarcoma with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR PULMONARY ARTERY INTIMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Pulmonary Artery Intimal Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PDGFRB and NFKBIA are two genes whose abnormalities are risk factors for Pulmonary Artery Intimal Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pulmonary Artery Intimal Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pulmonary Artery Intimal Sarcoma gene PDGFRB has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And NFKBIA has a causative impact on biological pathways like T-Cell Receptor Signaling and C-type Lectin Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PDGFRB and NFKBIA should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PDGFRB and NFKBIA should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Linolenic Acid, Beta-sitosterol, Vitamin C, Stigmasterol, Linoleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, P-coumaric Acid, Linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and TWEAK Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Apigenin can manipulate biochemical pathways TWEAK Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Pulmonary Artery Intimal Sarcoma due to abnormalities in genes PDGFRB and NFKBIA – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Ferulic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PULMONARY ARTERY INTIMAL SARCOMA DUE TO GENES PDGFRB AND NFKBIA
Eat more vegetables, Arugula or Onion?
The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Onion are Linolenic Acid, Beta-sitosterol, Diallyl Disulfide, Vitamin C, Protocatechuic Acid and others.
Vitamin A can manipulate biochemical pathways NFKB Signaling, Apoptosis and TWEAK Signaling. Kaempferol has biological action on biochemical pathways Cell Cycle Checkpoints, NFKB Signaling and TWEAK Signaling.
Diallyl Disulfide can manipulate biochemical pathways DNA Repair. Myricetin has biological action on biochemical pathways Oncogenic Histone Methylation. And so on.
For genetic risk of Pulmonary Artery Intimal Sarcoma due to abnormalities in genes PDGFRB and NFKBIA – Foods like Arugula are recommended compared to Onion. This is because the active ingredients Diallyl Disulfide and Myricetin in Onion further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER ONION FOR REDUCING THE GENETIC RISK OF PULMONARY ARTERY INTIMAL SARCOMA DUE TO GENES PDGFRB AND NFKBIA
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Papaya or Raspberry?
The active ingredients contained in Papaya are Linalool, Lycopene, Benzyl Isothiocyanate, Zeaxanthin, Linolenic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Resveratrol, Ellagic Acid, Rutin, Quercetin and others.
Lycopene can manipulate biochemical pathways NFKB Signaling, Apoptosis and TWEAK Signaling. Zeaxanthin has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and TWEAK Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Pulmonary Artery Intimal Sarcoma due to abnormalities in genes PDGFRB and NFKBIA – Foods like Papaya are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Zeaxanthin contained in Papaya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PAPAYA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF PULMONARY ARTERY INTIMAL SARCOMA DUE TO GENES PDGFRB AND NFKBIA
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Linoleic Acid, Oleic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Linolenic Acid, Vitamin C, Ellagic Acid, Linoleic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and TWEAK Signaling. Quercetin has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and TWEAK Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Pulmonary Artery Intimal Sarcoma due to abnormalities in genes PDGFRB and NFKBIA – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF PULMONARY ARTERY INTIMAL SARCOMA DUE TO GENES PDGFRB AND NFKBIA
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Pulmonary Artery Intimal Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels.
- Inhibitors of histone demethylases.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.