Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Histiocytosis when undergoing chemotherapy or when you determine you have a genetic risk for developing Histiocytosis because of ARAF and F13A1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Histiocytosis which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Stevia and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HISTIOCYTOSIS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Histiocytosis is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HISTIOCYTOSIS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Histiocytosis
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Histiocytosis from cBioPortal. The patients enrolled in the studies for Histiocytosis are in ages between 37 to 60 with an average age of 54. 70.8% of males and 29.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 29; the top genes with mutations and other abnormalities for Histiocytosis include genes ARAF, F13A1, ADAMTS1, ACOT1 and PTEN. The occurrence frequency distribution for these genes respectively is 16.7%, 16.7%, 8.3%, 8.3% and 8.3%. These tumor genetic details of Histiocytosis are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Histiocytosis.
Histiocytosis, also called Langerhans Cell Histiocytosis (LCH) is a rare systemic disorder that can damage tissue or cause lesions to form in one or more places in the body. Langerhans Cell histiocytosis occurs when the body produces too many Langerhans cells (histiocytes), which are a type of white blood cells that help fight infections. The over-production and buildup of these cells can lead to organ damage in adults with LCH. It is estimated that 63% of adults with LCH predominantly have lung disease only, pulmonary Langerhans cell histiocytosis, although it can also occur with involvement of other organs including bone, skin, lymph nodes, eyes, central nervous system, liver, spleen and bone marrow. Most adults with LCH have been found to be past or current smokers. Half of LCH tumors have been found to have an oncogenic mutation in the BRAF gene. Langerhans cell histiocytosis disorder has a wide spectrum of presentations and can be systemic since it can affect many different areas of the body. Most patients will survive the disease, some will remain symptom-free, while others may develop life-long problems. The patients’ chances of survival and maintaining good quality of life depend on individual case, but the course is less favorable for elderly patients, those with multiple locations of disease and those who may have risk organs such as lungs, liver, spleen and bone marrow involvement. Treatment options will vary based on nature of the disease being either single system or multisystem, low-risk or high-risk and may include chemotherapy, surgery, radiation therapy, photodynamic therapy, immunotherapy, targeted therapy, stem cell transplant and in some cases observation (wait and watch strategy). Optimal nutrition (foods and natural supplements) can support the treatment plans to enhance well-being of the patient.
(Ref: Kobayashi M and Tojo A, Cancer Sci., 2018; https://histio.org/langerhans-cell-histiocytosis-in-adults/; https://www.cancer.gov/types/langerhans/patient/langerhans-treatment-pdq)
Significance of Nutrition for Histiocytosis
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Histiocytosis. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Myricetin, Quercetin, Caffeic Acid, Vitamin C and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Histiocytosis, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Histiocytosis, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HISTIOCYTOSIS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Histiocytosis undergoing chemotherapy treatment
In Histiocytosis – the genes ARAF, F13A1, ADAMTS1, ACOT1 and PTEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Histiocytosis are RAS-RAF Signaling, DNA Repair, MAPK Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Oleic Acid, Betulinic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Vitamin A and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.
When treating Histiocytosis with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Folic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER PIGEON PEA FOR HISTIOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Tomato or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Tomato are Lycopene, Glucaric Acid, Lupeol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Celery are Quercetin, Glucaric Acid, Oleic Acid, Vitamin C, Myristicin and others.
Lycopene can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Histiocytosis with chemotherapy Radiation – Foods like Tomato are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Glucaric Acid contained in Tomato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: TOMATO IS RECOMMENDED OVER CELERY FOR HISTIOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Orange or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Oleic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Myricetin, Quercetin, Caffeic Acid, Vitamin C and others.
D-limonene can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways DNA Repair. And so on.
When treating Histiocytosis with chemotherapy Radiation – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Glucaric Acid contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR HISTIOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Linolenic Acid, Delphinidin, Cianidanol among others. While the active ingredients contained in Peanut are Quercetin, Oleic Acid, Vitamin E, Beta-sitosterol, Vitamin C and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, DNA Repair and MAPK Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways DNA Repair. And so on.
When treating Histiocytosis with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR HISTIOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Histiocytosis
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARAF and F13A1 are two genes whose abnormalities are risk factors for Histiocytosis. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Histiocytosis can be used as a guide for coming up with a recommended personalized nutrition plan. For Histiocytosis gene ARAF has causative impact on biological pathways like MAPK Signaling, RAS-RAF Signaling and Cytoskeletal Dynamics. And F13A1 has a causative impact on biological pathways like TGFB Signaling and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARAF and F13A1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARAF and F13A1 should be avoided.
Eat more pulses, Mung Bean or Moth Bean?
The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Glucaric Acid among others. While the active ingredients contained in Moth Bean are Oleic Acid, Beta-sitosterol, Stigmasterol, Linolenic Acid, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways TGFB Signaling, MYC Signaling and MAPK Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Histiocytosis due to abnormalities in genes ARAF and F13A1 – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Linolenic Acid and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF HISTIOCYTOSIS DUE TO GENES ARAF AND F13A1
Eat more vegetables, Jicama or Jute?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Jute are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.
For genetic risk of Histiocytosis due to abnormalities in genes ARAF and F13A1 – Foods like Jicama are recommended compared to Jute. This is because the active ingredients Linolenic Acid and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF HISTIOCYTOSIS DUE TO GENES ARAF AND F13A1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Malus (crab Apple)?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Malus (crab Apple) are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Lycopene has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Histiocytosis due to abnormalities in genes ARAF and F13A1 – Foods like Feijoa are recommended compared to Malus (crab Apple). This is because the active ingredients Linolenic Acid and Linoleic Acid in Malus (crab Apple) further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR REDUCING THE GENETIC RISK OF HISTIOCYTOSIS DUE TO GENES ARAF AND F13A1
Eat more nuts, Almond or Cashew Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Cashew Nut are Vitamin C, Gallic Acid, Beta-sitosterol, Butyric Acid, Vitamin K and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling, MAPK Signaling and RAS-RAF Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, mRNA Splicing and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Histiocytosis due to abnormalities in genes ARAF and F13A1 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF HISTIOCYTOSIS DUE TO GENES ARAF AND F13A1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Histiocytosis by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Gct Msk 2020
- Efficacy of MEK inhibition in patients with histiocytic neoplasms.
- Cryptorchidism: a pediatrician’s view.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
- Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.