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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Prostate Neuroendocrine Carcinoma!

Jul 28, 2023

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Introduction

Foods for Prostate Neuroendocrine Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Prostate Neuroendocrine Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Prostate Neuroendocrine Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Prostate Neuroendocrine Carcinoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Welsh Onion? Does it make any difference if fruit Elderberry is preferred over Java Plum? Also if similar choices are made for nuts/seeds like Common Hazelnut over European Chestnut and for pulses like Black-eyed Pea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Prostate Neuroendocrine Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Prostate Neuroendocrine Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Prostate Neuroendocrine Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Prostate Neuroendocrine Carcinoma. Biochemical pathways like Notch Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, G-protein-coupled Receptor Signaling are part of the signature definition of Prostate Neuroendocrine Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Elderberry contains active ingredients Quercetin, Apigenin, Curcumin, Myricetin, Luteolin. And Java Plum contains active ingredients Apigenin, Curcumin, Myricetin, Luteolin, Ellagic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Prostate Neuroendocrine Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Prostate Neuroendocrine Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Prostate Neuroendocrine Carcinoma?

Personalized nutrition for cancers like Prostate Neuroendocrine Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Prostate Neuroendocrine Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Prostate Neuroendocrine Carcinoma

All cancers like Prostate Neuroendocrine Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Prostate Neuroendocrine Carcinoma. Biochemical pathways like Notch Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, G-protein-coupled Receptor Signaling are part of the signature definition of Prostate Neuroendocrine Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Prostate Neuroendocrine Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Prostate Neuroendocrine Carcinoma when taking cancer treatment Carboplatin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MUC16, CPS1, ERCC2, CACNA1B and KMT2D are the top ranked reported genes for Prostate Neuroendocrine Carcinoma. MUC16 is reported in 21.2 % of the representative patients across all clinical trials. And CPS1 is reported in 12.1 %. The combined population patient data cover ages from 42 to 70. 100.0 % of the patient data are identified as men. The Prostate Neuroendocrine Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Prostate Neuroendocrine Carcinoma!

Food and Supplements for Prostate Neuroendocrine Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or WELSH ONION?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Luteolin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and MYC Signaling and others. Giant Butterbur is recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Carboplatin.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Luteolin, Daidzein, Lupeol, Isorhamnetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oxidative Stress and others. Welsh Onion is not recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER WELSH ONION FOR Prostate Neuroendocrine Carcinoma AND TREATMENT Carboplatin.

Choose Fruit JAVA PLUM or ELDERBERRY?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Luteolin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and MAPK Signaling and others. Java Plum is recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin. This is because Java Plum modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Carboplatin.

Some of the active ingredients or bioactives in fruit Elderberry are Quercetin, Apigenin, Curcumin, Myricetin, Luteolin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oxidative Stress and others. Elderberry is not recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT JAVA PLUM IS RECOMMENDED OVER ELDERBERRY FOR Prostate Neuroendocrine Carcinoma AND TREATMENT Carboplatin.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Myricetin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Hedgehog Signaling and others. Common Hazelnut is recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Carboplatin.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Apigenin, Curcumin, Myricetin, Luteolin. These active ingredients manipulate various biochemical pathways like DNA Repair, WNT Beta Catenin Signaling and Oxidative Stress and others. European Chestnut is not recommended for Prostate Neuroendocrine Carcinoma when ongoing cancer treatment is Carboplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Prostate Neuroendocrine Carcinoma AND TREATMENT Carboplatin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Prostate Neuroendocrine Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or CUCURBITA?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like P53 Signaling, Angiogenesis, Cell Cycle Checkpoints and MYC Signaling and others. Cauliflower is recommended for risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cucurbita are Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and MYC Signaling and others. Cucurbita is not recommended when risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER CUCURBITA FOR CACNA1B GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Angiogenesis and MYC Signaling and others. Nance is recommended for risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and Stem Cell Signaling and others. Pummelo is not recommended when risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR CACNA1B GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and MYC Signaling and others. Butternut is recommended for risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Cashew Nut are Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended when risk of Prostate Neuroendocrine Carcinoma when associated genetic risk is CACNA1B because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR CACNA1B GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Prostate Neuroendocrine Carcinoma. Prostate Neuroendocrine Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Prostate Neuroendocrine Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Prostate Neuroendocrine Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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