Foods for Pleomorphic Liposarcoma!

Introduction

Foods for Pleomorphic Liposarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Pleomorphic liposarcoma, a rare and aggressive form of cancer, poses significant challenges in both diagnosis and treatment. This cancer type is characterized in detail in pleomorphic liposarcoma pathology outlines, highlighting its unique cellular structure. Radiology, especially MRI, plays a crucial role in the detection and assessment of the tumor, aiding in the determination of its size, location, and potential metastasis. The ICD-10 code for pleomorphic liposarcoma standardizes its classification in medical records. Patients diagnosed with this cancer often face a variable prognosis, largely dependent on factors such as the stage of the disease, with stage 4 indicating advanced cancer. Treatment typically involves a combination of surgery and chemotherapy, with the survival rate being an important consideration in treatment planning. Symptoms of pleomorphic liposarcoma can vary, making early detection challenging. Metastasis is a significant concern, as it can complicate treatment and affect prognosis. Research into the molecular aspects of the disease, including the role of MDM2, provides insights into potential therapeutic targets. Additionally, understanding the relationship between pleomorphic liposarcoma and dedifferentiated liposarcoma is critical for accurate diagnosis and appropriate treatment selection. Addressing the cause and risk factors of pleomorphic liposarcoma is also an area of ongoing study, essential for prevention and early intervention strategies.

For Pleomorphic Liposarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Pleomorphic Liposarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Pleomorphic Liposarcoma?

For example does it matter if vegetable Garden Cress is consumed more compared to Arrowroot? Does it make any difference if fruit Pummelo is preferred over Mango? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Black-eyed Pea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Pleomorphic Liposarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Pleomorphic Liposarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Catechol, Quercetin, Curcumin, Formononetin, Daidzein. And Mango contains active ingredients Catechol, Quercetin, Curcumin, Formononetin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Pleomorphic Liposarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Pleomorphic Liposarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Pleomorphic Liposarcoma?

Personalized nutrition for cancers like Pleomorphic Liposarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Pleomorphic Liposarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Pleomorphic Liposarcoma

All cancers like Pleomorphic Liposarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Pleomorphic Liposarcoma. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle are part of the signature definition of Pleomorphic Liposarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Pleomorphic Liposarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Pleomorphic Liposarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3R1, AR, KDM6A, RB1 and CD79B are the top ranked reported genes for Pleomorphic Liposarcoma. PIK3R1 is reported in 6.2 % of the representative patients across all clinical trials. And AR is reported in 6.2 %. The combined population patient data cover ages from to . 51.5 % of the patient data are identified as men. The Pleomorphic Liposarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Pleomorphic Liposarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN CRESS or ARROWROOT?

Vegetable Garden Cress contains many active ingredients or bioactives such as Catechol, Curcumin, Formononetin, Benzyl Isothiocyanate, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Angiogenesis and MYC Signaling and others. Garden Cress is recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation. This is because Garden Cress modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Arrowroot are Catechol, Quercetin, Curcumin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Arrowroot is not recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN CRESS IS RECOMMENDED OVER ARROWROOT FOR Pleomorphic Liposarcoma AND TREATMENT Radiation.

Choose Fruit MANGO or PUMMELO?

Fruit Mango contains many active ingredients or bioactives such as Catechol, Quercetin, Curcumin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Survival, RAS-RAF Signaling and Angiogenesis and others. Mango is recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation. This is because Mango modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Catechol, Quercetin, Curcumin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT MANGO IS RECOMMENDED OVER PUMMELO FOR Pleomorphic Liposarcoma AND TREATMENT Radiation.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Catechol, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Survival, Angiogenesis, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Butternut is recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Catechol, Quercetin, Ellagic Acid, Curcumin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. European Chestnut is not recommended for Pleomorphic Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Pleomorphic Liposarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Pleomorphic Liposarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GREEN BELL PEPPER or WHITE CABBAGE?

Vegetable Green Bell Pepper contains many active ingredients or bioactives such as Quercetin, Curcumin, Vitamin D3, Lupeol, Resveratrol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Angiogenesis and Inositol Phosphate Signaling and others. Green Bell Pepper is recommended for risk of Pleomorphic Liposarcoma when associated genetic risk is AR. This is because Green Bell Pepper increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. White Cabbage is not recommended when risk of Pleomorphic Liposarcoma when associated genetic risk is AR because it increases the signature pathways of it.

VEGETABLE GREEN BELL PEPPER IS RECOMMENDED OVER WHITE CABBAGE FOR AR GENETIC RISK OF CANCER.

Choose Fruit NANCE or PRICKLY PEAR?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Inositol Phosphate Signaling and MYC Signaling and others. Nance is recommended for risk of Pleomorphic Liposarcoma when associated genetic risk is AR. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Prickly Pear are Apigenin, Quercetin, Curcumin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Prickly Pear is not recommended when risk of Pleomorphic Liposarcoma when associated genetic risk is AR because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PRICKLY PEAR FOR AR GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Inositol Phosphate Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Pleomorphic Liposarcoma when associated genetic risk is AR. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Chestnut is not recommended when risk of Pleomorphic Liposarcoma when associated genetic risk is AR because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR AR GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Pleomorphic Liposarcoma. Pleomorphic Liposarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Pleomorphic Liposarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Cress contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Pleomorphic Liposarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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