Which Foods are Recommended for Pleomorphic Liposarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pleomorphic Liposarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pleomorphic Liposarcoma because of PIK3R1 and AR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pleomorphic Liposarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Resveratrol and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PLEOMORPHIC LIPOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pleomorphic Liposarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PLEOMORPHIC LIPOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pleomorphic Liposarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pleomorphic Liposarcoma from cBioPortal. 51.5% of males and 48.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 34; the top genes with mutations and other abnormalities for Pleomorphic Liposarcoma include genes PIK3R1, AR, KDM6A, RB1 and CD79B. The occurrence frequency distribution for these genes respectively is 6.2%, 6.2%, 6.2%, 6.2% and 3.1%. These tumor genetic details of Pleomorphic Liposarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pleomorphic Liposarcoma.

Significance of Nutrition for Pleomorphic Liposarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pleomorphic Liposarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Oleic Acid, Lupeol, Apigenin, Beta-sitosterol and others. And Mulberry contains active ingredients Resveratrol, Morusin, Deoxynojirimycin, Moracin P and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pleomorphic Liposarcoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pleomorphic Liposarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PLEOMORPHIC LIPOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pleomorphic Liposarcoma undergoing chemotherapy treatment

In Pleomorphic Liposarcoma – the genes PIK3R1, AR, KDM6A, RB1 and CD79B have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pleomorphic Liposarcoma are RAS-RAF Signaling, Growth Factor Signaling, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Growth Factor Signaling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Oleic Acid, Lupeol, Daidzein, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Moth Bean are Oleic Acid, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and Angiogenesis.

Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Pleomorphic Liposarcoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER MOTH BEAN FOR PLEOMORPHIC LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Carrot or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Carrot are Quercetin, Oleic Acid, Lupeol, Linalool, Vitamin E among others. While the active ingredients contained in Spinach are Quercetin, Oleic Acid, Apigenin, Beta-sitosterol, Vitamin C and others.

Gamma-linolenic Acid can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Beta-caryophyllene has biological action on biochemical pathways Cell Survival, JAK-STAT Signaling and Angiogenesis.

Apigenin can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.

When treating Pleomorphic Liposarcoma with chemotherapy Radiation – Foods like Carrot are recommended compared to Spinach. This is because the active ingredients Apigenin and Linoleic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gamma-linolenic Acid and Beta-caryophyllene contained in Carrot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CARROT IS RECOMMENDED OVER SPINACH FOR PLEOMORPHIC LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Mulberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin, Moracin P among others. While the active ingredients contained in Date are Quercetin, Oleic Acid, Lupeol, Apigenin, Beta-sitosterol and others.

Morusin can manipulate biochemical pathways JAK-STAT Signaling, Cell Survival and MYC Signaling. Deoxynojirimycin has biological action on biochemical pathways Cell Survival.

Apigenin can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.

When treating Pleomorphic Liposarcoma with chemotherapy Radiation – Foods like Mulberry are recommended compared to Date. This is because the active ingredients Apigenin and Linoleic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER DATE FOR PLEOMORPHIC LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways DNA Repair, Cell Survival and MYC Signaling. Cianidanol has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and RAS-RAF Signaling. And so on.

When treating Pleomorphic Liposarcoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR PLEOMORPHIC LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Pleomorphic Liposarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PIK3R1 and AR are two genes whose abnormalities are risk factors for Pleomorphic Liposarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pleomorphic Liposarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pleomorphic Liposarcoma gene PIK3R1 has causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. And AR has a causative impact on biological pathways like Androgen Signaling and Cytoskeletal Dynamics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PIK3R1 and AR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PIK3R1 and AR should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Vitexin among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others.

Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Pleomorphic Liposarcoma due to abnormalities in genes PIK3R1 and AR – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC LIPOSARCOMA DUE TO GENES PIK3R1 AND AR

Eat more vegetables, Cassava or Carob?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Phloroglucinol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Pleomorphic Liposarcoma due to abnormalities in genes PIK3R1 and AR – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC LIPOSARCOMA DUE TO GENES PIK3R1 AND AR

Eat more fruits, Orange or Raspberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Oleic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Quercetin, Vitamin C, Salicylic Acid and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Pleomorphic Liposarcoma due to abnormalities in genes PIK3R1 and AR – Foods like Orange are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC LIPOSARCOMA DUE TO GENES PIK3R1 AND AR

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and DAP12 Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Pleomorphic Liposarcoma due to abnormalities in genes PIK3R1 and AR – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC LIPOSARCOMA DUE TO GENES PIK3R1 AND AR

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pleomorphic Liposarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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