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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Pancreatobiliary Ampullary Carcinoma?

Aug 24, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pancreatobiliary Ampullary Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pancreatobiliary Ampullary Carcinoma because of SMAD4 and MED12 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pancreatobiliary Ampullary Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Salmonberry in my diet” or “Should I reduce consumption of vegetable Parsnip” or “Can I take Modified Citrus Pectin and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PANCREATOBILIARY AMPULLARY CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pancreatobiliary Ampullary Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PANCREATOBILIARY AMPULLARY CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Pancreatobiliary Ampullary Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pancreatobiliary Ampullary Carcinoma from cBioPortal. 62.5% of males and 37.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 8; the top genes with mutations and other abnormalities for Pancreatobiliary Ampullary Carcinoma include genes TP53, KRAS, SMAD4, MED12 and CTNNB1. The occurrence frequency distribution for these genes respectively is 71.4%, 42.9%, 28.6%, 14.3% and 14.3%. These tumor genetic details of Pancreatobiliary Ampullary Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pancreatobiliary Ampullary Carcinoma.

Significance of Nutrition for Pancreatobiliary Ampullary Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pancreatobiliary Ampullary Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Modified Citrus Pectin, Glucaric Acid, Beta-sitosterol, Vitamin C, Linolenic Acid and others. And Salmonberry contains active ingredients Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pancreatobiliary Ampullary Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pancreatobiliary Ampullary Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Pancreatobiliary Ampullary Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PANCREATOBILIARY AMPULLARY CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pancreatobiliary Ampullary Carcinoma undergoing chemotherapy treatment

In Pancreatobiliary Ampullary Carcinoma – the genes TP53, KRAS, SMAD4, MED12 and CTNNB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pancreatobiliary Ampullary Carcinoma are RAS-RAF Signaling, DNA Repair, MAPK Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Adzuki Bean are Glucaric Acid, Isoliquiritigenin, Genistein, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Epithelial to Mesenchymal Transition.

Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.

When treating Pancreatobiliary Ampullary Carcinoma with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR PANCREATOBILIARY AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Parsnip?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Psoralen, Vitamin C, Gallic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Beta-carotene has biological action on biochemical pathways DNA Repair, TGFB Signaling and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways TGFB Signaling and Epithelial to Mesenchymal Transition. And so on.

When treating Pancreatobiliary Ampullary Carcinoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Parsnip. This is because the active ingredients Oleic Acid and Linoleic Acid in Parsnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER PARSNIP FOR PANCREATOBILIARY AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Pancreatobiliary Ampullary Carcinoma?

Eat more fruits, Salmonberry or Peach?

Fruits are an important part of many diets. The active ingredients contained in Salmonberry are Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Glucaric Acid, Beta-sitosterol, Vitamin C, Linolenic Acid and others.

Protocatechuic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. P-coumaric Acid has biological action on biochemical pathways TGFB Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Fisetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. And so on.

When treating Pancreatobiliary Ampullary Carcinoma with chemotherapy Radiation – Foods like Salmonberry are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Protocatechuic Acid and P-coumaric Acid contained in Salmonberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SALMONBERRY IS RECOMMENDED OVER PEACH FOR PANCREATOBILIARY AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Pancreatobiliary Ampullary Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR PANCREATOBILIARY AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Pancreatobiliary Ampullary Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMAD4 and MED12 are two genes whose abnormalities are risk factors for Pancreatobiliary Ampullary Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pancreatobiliary Ampullary Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pancreatobiliary Ampullary Carcinoma gene SMAD4 has causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. And MED12 has a causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMAD4 and MED12 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMAD4 and MED12 should be avoided.

Eat more pulses, Scarlet Bean or Moth Bean?

The active ingredients contained in Scarlet Bean are Linolenic Acid, Vitamin C, Oleic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Oleic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and TGFB Signaling. And so on.

For genetic risk of Pancreatobiliary Ampullary Carcinoma due to abnormalities in genes SMAD4 and MED12 – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF PANCREATOBILIARY AMPULLARY CARCINOMA DUE TO GENES SMAD4 AND MED12

Eat more vegetables, Cassava or Chinese Mustard?

The active ingredients contained in Cassava are Linolenic Acid, Vitamin C, Oleic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Chinese Mustard are Quercetin, Isorhamnetin, Indole-3-carbinol, Kaempferol, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Pancreatobiliary Ampullary Carcinoma due to abnormalities in genes SMAD4 and MED12 – Foods like Cassava are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Folic Acid in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF PANCREATOBILIARY AMPULLARY CARCINOMA DUE TO GENES SMAD4 AND MED12

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Date?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Date are Apigenin, Protocatechuic Acid, Quercetin, Lupeol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Apigenin can manipulate biochemical pathways TGFB Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Pancreatobiliary Ampullary Carcinoma due to abnormalities in genes SMAD4 and MED12 – Foods like Feijoa are recommended compared to Date. This is because the active ingredients Apigenin and Ferulic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF PANCREATOBILIARY AMPULLARY CARCINOMA DUE TO GENES SMAD4 AND MED12

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and Cell Cycle Checkpoints.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Pancreatobiliary Ampullary Carcinoma due to abnormalities in genes SMAD4 and MED12 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF PANCREATOBILIARY AMPULLARY CARCINOMA DUE TO GENES SMAD4 AND MED12


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pancreatobiliary Ampullary Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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