Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Neuroendocrine Tumor Of The Appendix when undergoing chemotherapy or when you determine you have a genetic risk for developing Neuroendocrine Tumor Of The Appendix because of ATM and ASXL1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Neuroendocrine Tumor Of The Appendix which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Gooseberry in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Cinnamon and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO NEUROENDOCRINE TUMOR OF THE APPENDIX, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Neuroendocrine Tumor Of The Appendix is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR NEUROENDOCRINE TUMOR OF THE APPENDIX, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Neuroendocrine Tumor Of The Appendix
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Neuroendocrine Tumor Of The Appendix from cBioPortal. The patients enrolled in the studies for Neuroendocrine Tumor Of The Appendix are in ages between 21 to 89 with an average age of 60. 48.7% of males and 51.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 113; the top genes with mutations and other abnormalities for Neuroendocrine Tumor Of The Appendix include genes DNMT3A, TET2, ASXL1, ATM and TP53. The occurrence frequency distribution for these genes respectively is 29.0%, 12.9%, 6.5%, 6.5% and 6.5%. These tumor genetic details of Neuroendocrine Tumor Of The Appendix are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Neuroendocrine Tumor Of The Appendix.
Significance of Nutrition for Neuroendocrine Tumor Of The Appendix
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Neuroendocrine Tumor Of The Appendix. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Raspberry includes active ingredients Ellagic Acid, Quercetin, Vitamin C, Gallic Acid, Resveratrol and others. And Gooseberry contains active ingredients Modified Citrus Pectin, Beta-sitosterol, Linolenic Acid, Vitamin C, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Neuroendocrine Tumor Of The Appendix, activation or inhibition of selected biochemical pathways like RUNX Signaling, Notch Signaling, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Neuroendocrine Tumor Of The Appendix, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR NEUROENDOCRINE TUMOR OF THE APPENDIX – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Neuroendocrine Tumor Of The Appendix undergoing chemotherapy treatment
In Neuroendocrine Tumor Of The Appendix – the genes DNMT3A, TET2, ASXL1, ATM and TP53 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Neuroendocrine Tumor Of The Appendix are RUNX Signaling, Notch Signaling, Apoptosis and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RUNX Signaling, Notch Signaling, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Daidzein, Beta-sitosterol, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Genistein can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Neuroendocrine Tumor Of The Appendix with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR NEUROENDOCRINE TUMOR OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Milk Thistle or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Milk Thistle are Vitamin E, Silibinin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Linolenic Acid, Vitamin C, Oleic Acid and others.
Silibinin can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, P53 Signaling and RUNX Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Neuroendocrine Tumor Of The Appendix with chemotherapy Carboplatin – Foods like Milk Thistle are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER CELERY FOR NEUROENDOCRINE TUMOR OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Gooseberry or Raspberry?
Fruits are an important part of many diets. The active ingredients contained in Gooseberry are Modified Citrus Pectin, Beta-sitosterol, Linolenic Acid, Vitamin C, Gallic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Vitamin C, Gallic Acid, Resveratrol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.
When treating Neuroendocrine Tumor Of The Appendix with chemotherapy Carboplatin – Foods like Gooseberry are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Gallic Acid contained in Gooseberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GOOSEBERRY IS RECOMMENDED OVER RASPBERRY FOR NEUROENDOCRINE TUMOR OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Beta-sitosterol, Quercetin, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, Notch Signaling and RUNX Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling. And so on.
When treating Neuroendocrine Tumor Of The Appendix with chemotherapy Carboplatin – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR NEUROENDOCRINE TUMOR OF THE APPENDIX ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Neuroendocrine Tumor Of The Appendix
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ATM and ASXL1 are two genes whose abnormalities are risk factors for Neuroendocrine Tumor Of The Appendix. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Neuroendocrine Tumor Of The Appendix can be used as a guide for coming up with a recommended personalized nutrition plan. For Neuroendocrine Tumor Of The Appendix gene ATM has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And ASXL1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ATM and ASXL1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ATM and ASXL1 should be avoided.
Eat more pulses, Scarlet Bean or Hyacinth Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid, Myristic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, mRNA Splicing and DNA Repair. Genistein has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Neuroendocrine Tumor Of The Appendix due to abnormalities in genes ATM and ASXL1 – Foods like Scarlet Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Genistein in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMOR OF THE APPENDIX DUE TO GENES ATM AND ASXL1
Eat more vegetables, Jicama or Heart Of Palm?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Beta-carotene, Folic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, mRNA Splicing and DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Neuroendocrine Tumor Of The Appendix due to abnormalities in genes ATM and ASXL1 – Foods like Jicama are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMOR OF THE APPENDIX DUE TO GENES ATM AND ASXL1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Papaya?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Papaya are Linalool, Vitamin C, Benzyl Isothiocyanate, Lycopene, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Suppressive Histone Methylation.
Zeaxanthin can manipulate biochemical pathways DNA Repair. Salicylic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Neuroendocrine Tumor Of The Appendix due to abnormalities in genes ATM and ASXL1 – Foods like Kiwi are recommended compared to Papaya. This is because the active ingredients Zeaxanthin and Salicylic Acid in Papaya further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER PAPAYA FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMOR OF THE APPENDIX DUE TO GENES ATM AND ASXL1
Eat more nuts, Pecan Nut or Brazil Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Neuroendocrine Tumor Of The Appendix due to abnormalities in genes ATM and ASXL1 – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMOR OF THE APPENDIX DUE TO GENES ATM AND ASXL1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Neuroendocrine Tumor Of The Appendix by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Met 2021
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Silibinin is a direct inhibitor of STAT3.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.