Foods for Myxoid Chondrosarcoma!

Introduction

Foods for Myxoid Chondrosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Myxoid Chondrosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Myxoid Chondrosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Myxoid Chondrosarcoma?

For example does it matter if vegetable Spinach is consumed more compared to Swamp Cabbage? Does it make any difference if fruit Black Elderberry is preferred over Medlar? Also if similar choices are made for nuts/seeds like Almond over European Chestnut and for pulses like Winged Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Myxoid Chondrosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Myxoid Chondrosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Black Elderberry contains active ingredients Apigenin, Curcumin, Lupeol, Linalool, Lycopene. And Medlar contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Myxoid Chondrosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Myxoid Chondrosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Myxoid Chondrosarcoma?

Personalized nutrition for cancers like Myxoid Chondrosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Myxoid Chondrosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Myxoid Chondrosarcoma

All cancers like Myxoid Chondrosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Myxoid Chondrosarcoma. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Sirtuin Signaling, Oncogenic Cancer Epigenetics are part of the signature definition of Myxoid Chondrosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Myxoid Chondrosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Myxoid Chondrosarcoma when taking cancer treatment Dactinomycin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

IDH1, TERT, TP53, ATP2B3 and COL6A1 are the top ranked reported genes for Myxoid Chondrosarcoma. IDH1 is reported in 20.0 % of the representative patients across all clinical trials. And TERT is reported in 20.0 %. The combined population patient data cover ages from to . 80.0 % of the patient data are identified as men. The Myxoid Chondrosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Myxoid Chondrosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable SPINACH or SWAMP CABBAGE?

Vegetable Spinach contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Cycle Checkpoints and others. Spinach is recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin. This is because Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dactinomycin.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Curcumin, Lupeol, Lycopene, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and others. Swamp Cabbage is not recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE SPINACH IS RECOMMENDED OVER SWAMP CABBAGE FOR Myxoid Chondrosarcoma AND TREATMENT Dactinomycin.

Choose Fruit MEDLAR or BLACK ELDERBERRY?

Fruit Medlar contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Cycle Checkpoints and others. Medlar is recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin. This is because Medlar modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dactinomycin.

Some of the active ingredients or bioactives in fruit Black Elderberry are Apigenin, Curcumin, Lupeol, Linalool, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and others. Black Elderberry is not recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT MEDLAR IS RECOMMENDED OVER BLACK ELDERBERRY FOR Myxoid Chondrosarcoma AND TREATMENT Dactinomycin.

Choose Nut ALMOND or EUROPEAN CHESTNUT?

Almond contains many active ingredients or bioactives such as Curcumin, Lupeol, Phloretin, Formononetin, Eugenol. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Cycle Checkpoints and others. Almond is recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dactinomycin.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Lupeol, Eugenol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and others. European Chestnut is not recommended for Myxoid Chondrosarcoma when ongoing cancer treatment is Dactinomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Myxoid Chondrosarcoma AND TREATMENT Dactinomycin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Myxoid Chondrosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CELERY STALKS or COMMON CABBAGE?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Angiogenesis and Cell Cycle Checkpoints and others. Celery Stalks is recommended for risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3. This is because Celery Stalks increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Common Cabbage are Curcumin, Quercetin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and others. Common Cabbage is not recommended when risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER COMMON CABBAGE FOR ATP2B3 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Angiogenesis and Cell Cycle Checkpoints and others. Red Raspberry is recommended for risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Small Molecule Transport and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR ATP2B3 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Small Molecule Transport and Angiogenesis and others. Butternut is recommended for risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Small Molecule Transport and Oncogenic Cancer Epigenetics and others. Chestnut is not recommended when risk of Myxoid Chondrosarcoma when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR ATP2B3 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Myxoid Chondrosarcoma. Myxoid Chondrosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Myxoid Chondrosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Myxoid Chondrosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Sarcoma Mskcc 2022
• Pan-cancer analysis of whole genomes.
• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Induction of apoptosis of SW480 human colon cancer cells by (-)-epicatechin isolated from Bulnesia sarmienti.
• Effects and significance of formononetin on expression levels of HIF-1α and VEGF in mouse cervical cancer tissue.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.