Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hurthle Cell Thyroid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Hurthle Cell Thyroid Cancer because of DICER1 and SMARCA4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Hurthle Cell Thyroid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Elderberry” or “Include fruit Kiwi in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Lavender and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HURTHLE CELL THYROID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Hurthle Cell Thyroid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HURTHLE CELL THYROID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Hurthle Cell Thyroid Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Hurthle Cell Thyroid Cancer from cBioPortal. 60.9% of males and 39.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 23; the top genes with mutations and other abnormalities for Hurthle Cell Thyroid Cancer include genes TERT, KMT2C, DICER1, SMARCA4 and NRAS. The occurrence frequency distribution for these genes respectively is 50.0%, 37.5%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Hurthle Cell Thyroid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hurthle Cell Thyroid Cancer.
Significance of Nutrition for Hurthle Cell Thyroid Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hurthle Cell Thyroid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Elderberry includes active ingredients Lupeol, Betulinic Acid, Oleic Acid, Vitamin C, Quercetin and others. And Kiwi contains active ingredients Vitamin C, Quercetin, Vitamin A, Fisetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Hurthle Cell Thyroid Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, Apoptosis, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hurthle Cell Thyroid Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HURTHLE CELL THYROID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Hurthle Cell Thyroid Cancer undergoing chemotherapy treatment
In Hurthle Cell Thyroid Cancer – the genes TERT, KMT2C, DICER1, SMARCA4 and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hurthle Cell Thyroid Cancer are RAS-RAF Signaling, DNA Repair, Oxidative Stress and others. Sorafenib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair, Oxidative Stress so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Oleic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Oleic Acid, Beta-sitosterol, Caffeic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and Oxidative Stress.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hurthle Cell Thyroid Cancer with chemotherapy Sorafenib – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Genistein in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR HURTHLE CELL THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Vitamin C, Quercetin, Sulforaphane among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Oleic Acid, Vitamin C, Vitamin E, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Oxidative Stress. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Vitamin E can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hurthle Cell Thyroid Cancer with chemotherapy Sorafenib – Foods like Cabbage are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Citric Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BEETROOT FOR HURTHLE CELL THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.
Eat more fruits, Kiwi or Elderberry?
Fruits are an important part of many diets. The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Fisetin, Chlorogenic Acid among others. While the active ingredients contained in Elderberry are Lupeol, Betulinic Acid, Oleic Acid, Vitamin C, Quercetin and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Oxidative Stress. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Rutin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hurthle Cell Thyroid Cancer with chemotherapy Sorafenib – Foods like Kiwi are recommended compared to Elderberry. This is because the active ingredients Rutin and Kaempferol in Elderberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Kiwi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KIWI IS RECOMMENDED OVER ELDERBERRY FOR HURTHLE CELL THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Walnut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Oleic Acid, Quercetin, Vitamin E, Linoleic Acid, Vitamin A among others. While the active ingredients contained in Walnut are D-limonene, Protocatechuic Acid, Ellagic Acid, Betulinic Acid, Oleic Acid and others.
Quercetin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways Oxidative Stress, MYC Signaling and PI3K-AKT-MTOR Signaling.
D-limonene can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Hurthle Cell Thyroid Cancer with chemotherapy Sorafenib – Foods like Hazelnut are recommended compared to Walnut. This is because the active ingredients D-limonene and Ellagic Acid in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin A contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER WALNUT FOR HURTHLE CELL THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Hurthle Cell Thyroid Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DICER1 and SMARCA4 are two genes whose abnormalities are risk factors for Hurthle Cell Thyroid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hurthle Cell Thyroid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Hurthle Cell Thyroid Cancer gene DICER1 has causative impact on biological pathways like NFKB Signaling and Apoptosis. And SMARCA4 has a causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DICER1 and SMARCA4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DICER1 and SMARCA4 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Genistein, Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Genistein, Daidzein, Quercetin, Cianidanol, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ferulic Acid can manipulate biochemical pathways DNA Repair and Growth Factor Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Hurthle Cell Thyroid Cancer due to abnormalities in genes DICER1 and SMARCA4 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF HURTHLE CELL THYROID CANCER DUE TO GENES DICER1 AND SMARCA4
Eat more vegetables, Cassava or Celery?
The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Hurthle Cell Thyroid Cancer due to abnormalities in genes DICER1 and SMARCA4 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF HURTHLE CELL THYROID CANCER DUE TO GENES DICER1 AND SMARCA4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Peach?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Oleic Acid, Beta-sitosterol, Vitamin C, Modified Citrus Pectin, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Hurthle Cell Thyroid Cancer due to abnormalities in genes DICER1 and SMARCA4 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF HURTHLE CELL THYROID CANCER DUE TO GENES DICER1 AND SMARCA4
Eat more nuts, Pecan Nut or Macadamia Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Delphinidin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Hurthle Cell Thyroid Cancer due to abnormalities in genes DICER1 and SMARCA4 – Foods like Pecan Nut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF HURTHLE CELL THYROID CANCER DUE TO GENES DICER1 AND SMARCA4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Hurthle Cell Thyroid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.