Which Foods are Recommended for Adrenocortical Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adrenocortical Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Adrenocortical Carcinoma because of CTNNB1 and FAT4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Adrenocortical Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Papaya in my diet” or “Should I reduce consumption of vegetable Brussels Sprout” or “Can I take Cordyceps and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADRENOCORTICAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Adrenocortical Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADRENOCORTICAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Adrenocortical Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Adrenocortical Carcinoma from cBioPortal. The patients enrolled in the studies for Adrenocortical Carcinoma are in ages between 1 to 88 with an average age of 52. 35.7% of males and 64.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 182; the top genes with mutations and other abnormalities for Adrenocortical Carcinoma include genes CTNNB1, MUC16, FAT4, MEN1 and KMT2B. The occurrence frequency distribution for these genes respectively is 12.3%, 12.3%, 6.1%, 6.1% and 5.3%. These tumor genetic details of Adrenocortical Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adrenocortical Carcinoma.

Significance of Nutrition for Adrenocortical Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adrenocortical Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Resveratrol, Ellagic Acid, Myricetin, Caffeic Acid, Vitamin C and others. And Papaya contains active ingredients Lycopene, Beta-sitosterol, Benzyl Isothiocyanate, Oleic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Adrenocortical Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Amino Acid Metabolism, Small Molecule Transport, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adrenocortical Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADRENOCORTICAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Adrenocortical Carcinoma undergoing chemotherapy treatment

In Adrenocortical Carcinoma – the genes CTNNB1, MUC16, FAT4, MEN1 and KMT2B have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adrenocortical Carcinoma are Cell Cycle, Amino Acid Metabolism, RUNX Signaling and others. Etoposide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Amino Acid Metabolism, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Oleic Acid, Vitamin C among others. While the active ingredients contained in Fava Bean are Caffeic Acid, Beta-sitosterol, Butein, Daidzein, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, MYC Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways Vitamin D Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Caffeic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways DNA Repair. And so on.

When treating Adrenocortical Carcinoma with chemotherapy Etoposide – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Caffeic Acid and Genistein in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR ADRENOCORTICAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Eat more vegetables, Parsnip or Brussels Sprout?

Vegetables are an important part of many diets. The active ingredients contained in Parsnip are Psoralen, Imperatorin, Angelicin, Oleic Acid, Vitamin C among others. While the active ingredients contained in Brussels Sprout are Sulforaphane, Beta-sitosterol, Oleic Acid, Vitamin C, Brassinin and others.

Imperatorin can manipulate biochemical pathways NFKB Signaling, MYC Signaling and Vitamin D Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair, WNT Beta Catenin Signaling and MAPK Signaling.

Indole-3-carbinol can manipulate biochemical pathways DNA Repair. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.

When treating Adrenocortical Carcinoma with chemotherapy Etoposide – Foods like Parsnip are recommended compared to Brussels Sprout. This is because the active ingredients Indole-3-carbinol and Linolenic Acid in Brussels Sprout interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Imperatorin and Ferulic Acid contained in Parsnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARSNIP IS RECOMMENDED OVER BRUSSELS SPROUT FOR ADRENOCORTICAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Eat more fruits, Papaya or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Papaya are Lycopene, Beta-sitosterol, Benzyl Isothiocyanate, Oleic Acid, Vitamin C among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Myricetin, Caffeic Acid, Vitamin C and others.

Lycopene can manipulate biochemical pathways NFKB Signaling, MYC Signaling and WNT Beta Catenin Signaling. Zeaxanthin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Resveratrol can manipulate biochemical pathways DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Vitamin D Signaling. And so on.

When treating Adrenocortical Carcinoma with chemotherapy Etoposide – Foods like Papaya are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Zeaxanthin contained in Papaya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PAPAYA IS RECOMMENDED OVER CRANBERRY FOR ADRENOCORTICAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Delphinidin, Linolenic Acid among others. While the active ingredients contained in Acorn are Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid, Quercetin and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Cianidanol has biological action on biochemical pathways RUNX Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.

When treating Adrenocortical Carcinoma with chemotherapy Etoposide – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR ADRENOCORTICAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Adrenocortical Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and FAT4 are two genes whose abnormalities are risk factors for Adrenocortical Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adrenocortical Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Adrenocortical Carcinoma gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And FAT4 has a causative impact on biological pathways like Cytoskeletal Dynamics and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and FAT4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and FAT4 should be avoided.

Eat more pulses, Scarlet Bean or Pigeon Pea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Adrenocortical Carcinoma due to abnormalities in genes CTNNB1 and FAT4 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF ADRENOCORTICAL CARCINOMA DUE TO GENES CTNNB1 AND FAT4

Eat more vegetables, Cassava or Yam?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Yam are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Dioscin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Beta-sitosterol has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Adrenocortical Carcinoma due to abnormalities in genes CTNNB1 and FAT4 – Foods like Cassava are recommended compared to Yam. This is because the active ingredients Oleic Acid and Linoleic Acid in Yam further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER YAM FOR REDUCING THE GENETIC RISK OF ADRENOCORTICAL CARCINOMA DUE TO GENES CTNNB1 AND FAT4

Eat more fruits, Kiwi or Peach?

The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Vitamin A, Chlorogenic Acid among others. While the active ingredients contained in Peach are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Modified Citrus Pectin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Adrenocortical Carcinoma due to abnormalities in genes CTNNB1 and FAT4 – Foods like Kiwi are recommended compared to Peach. This is because the active ingredients Fisetin and Oleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF ADRENOCORTICAL CARCINOMA DUE TO GENES CTNNB1 AND FAT4

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Quercetin, Linolenic Acid, Vitamin E, Oleic Acid, Vitamin A among others. While the active ingredients contained in Chestnut are Quercetin, Vitamin C, Linolenic Acid, Ellagic Acid, Oleic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin E has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Adrenocortical Carcinoma due to abnormalities in genes CTNNB1 and FAT4 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ADRENOCORTICAL CARCINOMA DUE TO GENES CTNNB1 AND FAT4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Adrenocortical Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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