Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Vaginal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Vaginal Adenocarcinoma because of ERBB3 and CHEK2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Vaginal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Mango” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Artemisinine and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO VAGINAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Vaginal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR VAGINAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Vaginal Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Vaginal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Vaginal Adenocarcinoma are in ages between 29 to 87 with an average age of 62.From a patient sample size of 16; the top genes with mutations and other abnormalities for Vaginal Adenocarcinoma include genes DNMT3A, CHEK2, CREBBP, ERBB3 and KIT. The occurrence frequency distribution for these genes respectively is 50.0%, 16.7%, 16.7%, 16.7% and 16.7%. These tumor genetic details of Vaginal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Vaginal Adenocarcinoma.
Significance of Nutrition for Vaginal Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Vaginal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Mango includes active ingredients Lupeol, Beta-sitosterol, Oleic Acid, Vitamin C, Linoleic Acid and others. And Raspberry contains active ingredients Ellagic Acid, Resveratrol, Quercetin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Vaginal Adenocarcinoma, activation or inhibition of selected biochemical pathways like DNA Repair, Oxidative Stress, Oncogenic Cancer Epigenetics, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Vaginal Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR VAGINAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Vaginal Adenocarcinoma undergoing chemotherapy treatment
In Vaginal Adenocarcinoma – the genes DNMT3A, CHEK2, CREBBP, ERBB3 and KIT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Vaginal Adenocarcinoma are DNA Repair, Oxidative Stress, PI3K-AKT-MTOR Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Oxidative Stress, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Yellow Wax Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Palmitic Acid, Butyric Acid, Ferulic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Soy Bean are Daidzein, Vitamin E, Lupeol, Quercetin, Beta-sitosterol and others.
Palmitic Acid can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Oxidative Stress.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Vaginal Adenocarcinoma with chemotherapy Cisplatin – Foods like Yellow Wax Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Genistein in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER SOY BEAN FOR VAGINAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Bamboo or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Bamboo are Beta-sitosterol, Oleic Acid, Ferulic Acid, Vitamin C, Beta-carotene among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Vitamin A, Linolenic Acid and others.
Ferulic Acid can manipulate biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Vitamin B3 has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Vaginal Adenocarcinoma with chemotherapy Cisplatin – Foods like Bamboo are recommended compared to Jute. This is because the active ingredients Quercetin and Vitamin B3 in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ferulic Acid and Beta-sitosterol contained in Bamboo support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BAMBOO IS RECOMMENDED OVER JUTE FOR VAGINAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Mango?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Quercetin, Vitamin C, Vitamin A among others. While the active ingredients contained in Mango are Lupeol, Beta-sitosterol, Oleic Acid, Vitamin C, Linoleic Acid and others.
Ellagic Acid can manipulate biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Vaginal Adenocarcinoma with chemotherapy Cisplatin – Foods like Raspberry are recommended compared to Mango. This is because the active ingredients Citric Acid and Gallic Acid in Mango interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER MANGO FOR VAGINAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Macadamia Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Macadamia Nut are Palmitic Acid, Beta-sitosterol, Lauric Acid, Myristic Acid, Folic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Vitamin A and others.
Palmitic Acid can manipulate biochemical pathways DNA Repair and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Oxidative Stress.
Quercetin can manipulate biochemical pathways Oxidative Stress. Vitamin B3 has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Vaginal Adenocarcinoma with chemotherapy Cisplatin – Foods like Macadamia Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Vitamin B3 in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Beta-sitosterol contained in Macadamia Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MACADAMIA NUT IS RECOMMENDED OVER ACORN FOR VAGINAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Vaginal Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB3 and CHEK2 are two genes whose abnormalities are risk factors for Vaginal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Vaginal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Vaginal Adenocarcinoma gene ERBB3 has causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And CHEK2 has a causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB3 and CHEK2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB3 and CHEK2 should be avoided.
Eat more pulses, Winged Bean or Pigeon Pea?
The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Linoleic Acid and others.
Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Vaginal Adenocarcinoma due to abnormalities in genes ERBB3 and CHEK2 – Foods like Winged Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF VAGINAL ADENOCARCINOMA DUE TO GENES ERBB3 AND CHEK2
Eat more vegetables, Jicama or Endive?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Endive are Vitamin C, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-carotene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Vaginal Adenocarcinoma due to abnormalities in genes ERBB3 and CHEK2 – Foods like Jicama are recommended compared to Endive. This is because the active ingredients Linoleic Acid and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF VAGINAL ADENOCARCINOMA DUE TO GENES ERBB3 AND CHEK2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Currant or Cranberry?
The active ingredients contained in Currant are Delphinidin, Cianidanol, Vitamin C, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Delphinidin, Hyperoside, Resveratrol, Vitamin C and others.
Delphinidin can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Vaginal Adenocarcinoma due to abnormalities in genes ERBB3 and CHEK2 – Foods like Currant are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Cianidanol contained in Currant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF VAGINAL ADENOCARCINOMA DUE TO GENES ERBB3 AND CHEK2
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Cianidanol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Growth Factor Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Vaginal Adenocarcinoma due to abnormalities in genes ERBB3 and CHEK2 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF VAGINAL ADENOCARCINOMA DUE TO GENES ERBB3 AND CHEK2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Vaginal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.