Foods for Vaginal Adenocarcinoma!

Introduction

Foods for Vaginal Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Adenocarcinoma of the vagina, a rare form of vaginal cancer, primarily arises from the glandular cells lining the vagina. This type of cancer is characterized by the malignant transformation of these cells, leading to the development of adenocarcinoma. Due to its rarity, the diagnosis and treatment of vaginal adenocarcinoma present unique challenges. Symptoms can vary but often include abnormal vaginal bleeding, discharge, and discomfort, which should prompt further medical evaluation. The treatment for adenocarcinoma vaginal cancer typically involves a multimodal approach, including surgery, radiation therapy, and chemotherapy, depending on the stage of the cancer and the patient’s overall health. Early detection and accurate diagnosis are crucial for effective management, as the prognosis for vaginal adenocarcinoma depends largely on the cancer’s stage at diagnosis and the response to treatment. The rarity of this cancer underscores the importance of awareness and education about its symptoms and the need for regular gynecological examinations for early detection and improved outcomes.

For Vaginal Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Vaginal Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Vaginal Adenocarcinoma?

For example does it matter if vegetable Wild Leek is consumed more compared to Mustard Spinach? Does it make any difference if fruit Babassu Palm is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Butternut over Brazil Nut and for pulses like Black-eyed Pea over Mung Bean. And if what I eat matters – then how does one identify foods which are recommended for Vaginal Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Vaginal Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Babassu Palm contains active ingredients Delphinidin, Curcumin, Isoliquiritigenin, Salicylic Acid, Formononetin. And Evergreen Blackberry contains active ingredients Ellagic Acid, Myricetin, Cinnamaldehyde, Linalool, Methyleugenol and possibly others.

A common mistake made when deciding and choosing foods to eat for Vaginal Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Vaginal Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Vaginal Adenocarcinoma?

Personalized nutrition for cancers like Vaginal Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Vaginal Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Vaginal Adenocarcinoma

All cancers like Vaginal Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Vaginal Adenocarcinoma. Biochemical pathways like Growth Factor Signaling, TGFB Signaling, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling are part of the signature definition of Vaginal Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Vaginal Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Vaginal Adenocarcinoma when taking cancer treatment Irinotecan, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, CHEK2, CREBBP, ERBB3 and KIT are the top ranked reported genes for Vaginal Adenocarcinoma. DNMT3A is reported in 50.0 % of the representative patients across all clinical trials. And CHEK2 is reported in 16.7 %. The combined population patient data cover ages from 29 to 87. 0.0 % of the patient data are identified as men. The Vaginal Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Vaginal Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable WILD LEEK or MUSTARD SPINACH?

Vegetable Wild Leek contains many active ingredients or bioactives such as Delphinidin, Curcumin, Isoliquiritigenin, Salicylic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Wild Leek is recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan. This is because Wild Leek modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in vegetable Mustard Spinach are Delphinidin, Curcumin, Isoliquiritigenin, Caffeine, Salicylic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and TGFB Signaling and others. Mustard Spinach is not recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE WILD LEEK IS RECOMMENDED OVER MUSTARD SPINACH FOR Vaginal Adenocarcinoma AND TREATMENT Irinotecan.

Choose Fruit EVERGREEN BLACKBERRY or BABASSU PALM?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Myricetin, Cinnamaldehyde, Linalool, Methyleugenol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Evergreen Blackberry is recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in fruit Babassu Palm are Delphinidin, Curcumin, Isoliquiritigenin, Salicylic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and TGFB Signaling and others. Babassu Palm is not recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER BABASSU PALM FOR Vaginal Adenocarcinoma AND TREATMENT Irinotecan.

Choose Nut BUTTERNUT or BRAZIL NUT?

Butternut contains many active ingredients or bioactives such as Delphinidin, Curcumin, Isoliquiritigenin, Caffeine, Salicylic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair, TGFB Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in Brazil Nut are Delphinidin, Curcumin, Ellagic Acid, Isoliquiritigenin, Salicylic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended for Vaginal Adenocarcinoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER BRAZIL NUT FOR Vaginal Adenocarcinoma AND TREATMENT Irinotecan.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Vaginal Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or YAM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Delphinidin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like Histone/Protein Acetylation, P53 Signaling, WNT Beta Catenin Signaling and MAPK Signaling and others. Giant Butterbur is recommended for risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Yam are Curcumin, Apigenin, Delphinidin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Yam is not recommended when risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER YAM FOR CHEK2 GENETIC RISK OF CANCER.

Choose Fruit BILBERRY or PUMMELO?

Fruit Bilberry contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Delphinidin, Myricetin. These active ingredients manipulate various biochemical pathways like P53 Signaling, MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Bilberry is recommended for risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2. This is because Bilberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2 because it increases the signature pathways of it.

FRUIT BILBERRY IS RECOMMENDED OVER PUMMELO FOR CHEK2 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Delphinidin, Myricetin. These active ingredients manipulate various biochemical pathways like Histone/Protein Acetylation, P53 Signaling, Hypoxia and MYC Signaling and others. Common Walnut is recommended for risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Ellagic Acid, Quercetin, Delphinidin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. European Chestnut is not recommended when risk of Vaginal Adenocarcinoma when associated genetic risk is CHEK2 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR CHEK2 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Vaginal Adenocarcinoma. Vaginal Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Vaginal Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Wild Leek contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Vaginal Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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