Which Foods are Recommended for Uterine Malignant Mixed Mullerian Tumor?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Malignant Mixed Mullerian Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Malignant Mixed Mullerian Tumor because of FBXW7 and PIK3R1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Uterine Malignant Mixed Mullerian Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Naranjilla” or “Include fruit Black Chokeberry in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Guggul and Quercetin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE MALIGNANT MIXED MULLERIAN TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Uterine Malignant Mixed Mullerian Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Uterine Malignant Mixed Mullerian Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Uterine Malignant Mixed Mullerian Tumor from cBioPortal. The patients enrolled in the studies for Uterine Malignant Mixed Mullerian Tumor are in ages between 44 to 84 with an average age of 64.From a patient sample size of 285; the top genes with mutations and other abnormalities for Uterine Malignant Mixed Mullerian Tumor include genes TP53, PIK3CA, KRAS, FBXW7 and PIK3R1. The occurrence frequency distribution for these genes respectively is 14.4%, 5.5%, 3.5%, 3.5% and 3.0%. These tumor genetic details of Uterine Malignant Mixed Mullerian Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Malignant Mixed Mullerian Tumor.

Significance of Nutrition for Uterine Malignant Mixed Mullerian Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Malignant Mixed Mullerian Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Naranjilla includes active ingredients Zeaxanthin, Beta-carotene, Vitamin A and others. And Black Chokeberry contains active ingredients Quercetin, Caffeic Acid, Isorhamnetin, Hyperoside, Isoquercitrin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Uterine Malignant Mixed Mullerian Tumor, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Malignant Mixed Mullerian Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Uterine Malignant Mixed Mullerian Tumor undergoing chemotherapy treatment

In Uterine Malignant Mixed Mullerian Tumor – the genes TP53, PIK3CA, KRAS, FBXW7 and PIK3R1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Malignant Mixed Mullerian Tumor are RAS-RAF Signaling, DNA Repair, Oncogenic Histone Methylation and others. Cetuximab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair, Oncogenic Histone Methylation so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Kaempferol, Vitamin C, Genistein among others. While the active ingredients contained in Lima Bean are Vitamin C, Genistein, Oleic Acid, Linoleic Acid, Vitamin A and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Inositol Phosphate Signaling. Kaempferol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and WNT Beta Catenin Signaling.

Genistein can manipulate biochemical pathways Lipid Metabolism. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

When treating Uterine Malignant Mixed Mullerian Tumor with chemotherapy Cetuximab – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR ON TREATMENT WITH CHEMOTHERAPY CETUXIMAB FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Adherens junction. Vitamin B3 has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Uterine Malignant Mixed Mullerian Tumor with chemotherapy Cetuximab – Foods like Jicama are recommended compared to Swede. This is because the active ingredients Linolenic Acid and Oleic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER SWEDE FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR ON TREATMENT WITH CHEMOTHERAPY CETUXIMAB FOR SOME CONDITIONS.

Eat more fruits, Black Chokeberry or Naranjilla?

Fruits are an important part of many diets. The active ingredients contained in Black Chokeberry are Quercetin, Caffeic Acid, Isorhamnetin, Hyperoside, Isoquercitrin among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.

Caffeic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Inositol Phosphate Signaling. Quercetin has biological action on biochemical pathways DCC Attractive Signaling, Adherens junction and Extracellular Matrix Remodelling.

Beta-carotene can manipulate biochemical pathways DNA Repair and MAPK Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

When treating Uterine Malignant Mixed Mullerian Tumor with chemotherapy Cetuximab – Foods like Black Chokeberry are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Caffeic Acid and Quercetin contained in Black Chokeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACK CHOKEBERRY IS RECOMMENDED OVER NARANJILLA FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR ON TREATMENT WITH CHEMOTHERAPY CETUXIMAB FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Linolenic Acid, Beta-sitosterol, Salicylic Acid, Gamma-linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Inositol Phosphate Signaling and Adherens junction. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and Vitamin D Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Lecithin has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Uterine Malignant Mixed Mullerian Tumor with chemotherapy Cetuximab – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR UTERINE MALIGNANT MIXED MULLERIAN TUMOR ON TREATMENT WITH CHEMOTHERAPY CETUXIMAB FOR SOME CONDITIONS.

Foods for Genetic Risk of Uterine Malignant Mixed Mullerian Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FBXW7 and PIK3R1 are two genes whose abnormalities are risk factors for Uterine Malignant Mixed Mullerian Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Malignant Mixed Mullerian Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Malignant Mixed Mullerian Tumor gene FBXW7 has causative impact on biological pathways like Antigen Presentation and Post Translation Modification. And PIK3R1 has a causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FBXW7 and PIK3R1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FBXW7 and PIK3R1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin E, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Uterine Malignant Mixed Mullerian Tumor due to abnormalities in genes FBXW7 and PIK3R1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF UTERINE MALIGNANT MIXED MULLERIAN TUMOR DUE TO GENES FBXW7 AND PIK3R1

Eat more vegetables, Giant Butterbur or Carob?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Phloroglucinol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Uterine Malignant Mixed Mullerian Tumor due to abnormalities in genes FBXW7 and PIK3R1 – Foods like Giant Butterbur are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF UTERINE MALIGNANT MIXED MULLERIAN TUMOR DUE TO GENES FBXW7 AND PIK3R1

Eat more fruits, Orange or Raspberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Oleic Acid among others. While the active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Resveratrol, Vitamin C, Salicylic Acid and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Uterine Malignant Mixed Mullerian Tumor due to abnormalities in genes FBXW7 and PIK3R1 – Foods like Orange are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF UTERINE MALIGNANT MIXED MULLERIAN TUMOR DUE TO GENES FBXW7 AND PIK3R1

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and DAP12 Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Uterine Malignant Mixed Mullerian Tumor due to abnormalities in genes FBXW7 and PIK3R1 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF UTERINE MALIGNANT MIXED MULLERIAN TUMOR DUE TO GENES FBXW7 AND PIK3R1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Uterine Malignant Mixed Mullerian Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Impact 2017
• Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes.
• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
• Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester.
• The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Research progress on the anticancer effects of vitamin K2.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.