Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Corpus Endometrial Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Corpus Endometrial Carcinoma because of RELA and MYC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Corpus Endometrial Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Grapefruit in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Thunder God and Vitamin D3 supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE CORPUS ENDOMETRIAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Corpus Endometrial Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Corpus Endometrial Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Corpus Endometrial Carcinoma from cBioPortal. From a patient sample size of 4; the top genes with mutations and other abnormalities for Uterine Corpus Endometrial Carcinoma include genes RELA, KMT2D, PTEN, MYC and ARID1A. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Uterine Corpus Endometrial Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Corpus Endometrial Carcinoma.
Significance of Nutrition for Uterine Corpus Endometrial Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Corpus Endometrial Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Vitamin C, Hyperoside, Caffeic Acid, Resveratrol, Linoleic Acid and others. And Grapefruit contains active ingredients Naringin, Linoleic Acid, Oleic Acid, Linolenic Acid, Naringenin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Corpus Endometrial Carcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, Amino Acid Metabolism, PI3K-AKT-MTOR Signaling, Angiogenesis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Corpus Endometrial Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Corpus Endometrial Carcinoma undergoing chemotherapy treatment
In Uterine Corpus Endometrial Carcinoma – the genes RELA, KMT2D, PTEN, MYC and ARID1A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Corpus Endometrial Carcinoma are Apoptosis, Amino Acid Metabolism, MAPK Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Amino Acid Metabolism, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linoleic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, Butein, P-coumaric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Vitamin D Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
When treating Uterine Corpus Endometrial Carcinoma with chemotherapy Carboplatin – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Linolenic Acid and Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Kaempferol, Erysolin among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Vitamin C, Linoleic Acid, Oleic Acid and others.
Vitamin A can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Amino Acid Metabolism and MYC Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
When treating Uterine Corpus Endometrial Carcinoma with chemotherapy Carboplatin – Foods like Arugula are recommended compared to Beetroot. This is because the active ingredients Linolenic Acid and Folic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BEETROOT FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Grapefruit or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Grapefruit are Naringin, Linoleic Acid, Oleic Acid, Linolenic Acid, Naringenin among others. While the active ingredients contained in Lingonberry are Vitamin C, Hyperoside, Caffeic Acid, Resveratrol, Linoleic Acid and others.
Naringin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Naringenin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Uterine Corpus Endometrial Carcinoma with chemotherapy Carboplatin – Foods like Grapefruit are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Linolenic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Naringin and Naringenin contained in Grapefruit support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAPEFRUIT IS RECOMMENDED OVER LINGONBERRY FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linoleic Acid, Oleic Acid, Vitamin A, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Myristic Acid, Lauric Acid, Folic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Vitamin D Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis. And so on.
When treating Uterine Corpus Endometrial Carcinoma with chemotherapy Carboplatin – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR UTERINE CORPUS ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Corpus Endometrial Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RELA and MYC are two genes whose abnormalities are risk factors for Uterine Corpus Endometrial Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Corpus Endometrial Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Corpus Endometrial Carcinoma gene RELA has causative impact on biological pathways like Immune Evasion Signaling and T-Cell Receptor Signaling. And MYC has a causative impact on biological pathways like Noncoding RNA Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RELA and MYC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RELA and MYC should be avoided.
Eat more pulses, Yellow Wax Bean or Pigeon Pea?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Palmitic Acid, Ferulic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linoleic Acid, Linolenic Acid, Oleic Acid, Vitamin A and others.
Vitamin A can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Uterine Corpus Endometrial Carcinoma due to abnormalities in genes RELA and MYC – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Vitamin C contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF UTERINE CORPUS ENDOMETRIAL CARCINOMA DUE TO GENES RELA AND MYC
Eat more vegetables, Mexican Groundcherry or Bell Pepper?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, P-coumaric Acid, Capsaicin, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Uterine Corpus Endometrial Carcinoma due to abnormalities in genes RELA and MYC – Foods like Mexican Groundcherry are recommended compared to Bell Pepper. This is because the active ingredients Linolenic Acid and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF UTERINE CORPUS ENDOMETRIAL CARCINOMA DUE TO GENES RELA AND MYC
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Vitamin C, P-coumaric Acid, Hyperoside, Resveratrol, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, Vitamin D Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Vitamin D Signaling. And so on.
For genetic risk of Uterine Corpus Endometrial Carcinoma due to abnormalities in genes RELA and MYC – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF UTERINE CORPUS ENDOMETRIAL CARCINOMA DUE TO GENES RELA AND MYC
Eat more nuts, Pecan Nut or Cashew Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Linoleic Acid, Linolenic Acid, Oleic Acid, Cianidanol among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Corpus Endometrial Carcinoma due to abnormalities in genes RELA and MYC – Foods like Pecan Nut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF UTERINE CORPUS ENDOMETRIAL CARCINOMA DUE TO GENES RELA AND MYC
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Corpus Endometrial Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells.
- Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Research progress on the anticancer effects of vitamin K2.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Sequence homology of surface membrane proteins of Babesia rodhaini.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.