Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Systemic Mastocytosis when undergoing chemotherapy or when you determine you have a genetic risk for developing Systemic Mastocytosis because of CNOT3 and FLT3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Systemic Mastocytosis which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Include fruit Apricot in my diet” or “Should I reduce consumption of vegetable Prairie Turnip” or “Can I take Guggul and Allspice supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SYSTEMIC MASTOCYTOSIS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Systemic Mastocytosis is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SYSTEMIC MASTOCYTOSIS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Systemic Mastocytosis
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Systemic Mastocytosis from cBioPortal. From a patient sample size of 2; the top genes with mutations and other abnormalities for Systemic Mastocytosis include genes CNOT3, DNMT3A, FLT3 and NPM1. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Systemic Mastocytosis are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Systemic Mastocytosis.
Significance of Nutrition for Systemic Mastocytosis
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Systemic Mastocytosis. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Prairie Turnip includes active ingredients Vitexin, Selenium, Folic Acid and others. And Apricot contains active ingredients Quercetin, Vitamin C, Modified Citrus Pectin, Oleic Acid, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Systemic Mastocytosis, activation or inhibition of selected biochemical pathways like JAK-STAT Signaling, MAPK Signaling, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Systemic Mastocytosis, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SYSTEMIC MASTOCYTOSIS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Systemic Mastocytosis undergoing chemotherapy treatment
In Systemic Mastocytosis – the genes CNOT3, DNMT3A, FLT3 and NPM1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Systemic Mastocytosis are JAK-STAT Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Midostaurin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers JAK-STAT Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Vitamin C, Daidzein, Linolenic Acid, Oleic Acid, Genistein among others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling. Daidzein has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling.
When treating Systemic Mastocytosis with chemotherapy Midostaurin – Foods like Black-eyed Pea are recommended. This is because the active ingredients Vitamin C and Daidzein contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED FOR SYSTEMIC MASTOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY MIDOSTAURIN FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Prairie Turnip?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Prairie Turnip are Vitexin, Selenium, Folic Acid and others.
Quercetin can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and JAK-STAT Signaling.
Folic Acid can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. And so on.
When treating Systemic Mastocytosis with chemotherapy Midostaurin – Foods like Asparagus are recommended compared to Prairie Turnip. This is because the active ingredients Folic Acid in Prairie Turnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER PRAIRIE TURNIP FOR SYSTEMIC MASTOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY MIDOSTAURIN FOR SOME CONDITIONS.
Eat more fruits, Apricot?
Fruits are an important part of many diets. The active ingredients contained in Apricot are Quercetin, Vitamin C, Modified Citrus Pectin, Oleic Acid, Linolenic Acid among others.
Rutin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and JAK-STAT Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
When treating Systemic Mastocytosis with chemotherapy Midostaurin – Foods like Apricot are recommended. This is because the active ingredients Rutin and Glucaric Acid contained in Apricot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: APRICOT IS RECOMMENDED FOR SYSTEMIC MASTOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY MIDOSTAURIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Salicylic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Lauric Acid, Myristic Acid, Palmitic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling.
Lauric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and MYC Signaling. And so on.
When treating Systemic Mastocytosis with chemotherapy Midostaurin – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR SYSTEMIC MASTOCYTOSIS ON TREATMENT WITH CHEMOTHERAPY MIDOSTAURIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Systemic Mastocytosis
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CNOT3 and FLT3 are two genes whose abnormalities are risk factors for Systemic Mastocytosis. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Systemic Mastocytosis can be used as a guide for coming up with a recommended personalized nutrition plan. For Systemic Mastocytosis gene CNOT3 has causative impact on biological pathways like DNA Repair. And FLT3 has a causative impact on biological pathways like Hypoxia, JAK-STAT Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CNOT3 and FLT3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CNOT3 and FLT3 should be avoided.
Eat more pulses, Mung Bean or Moth Bean?
The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Glucaric Acid, Linolenic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Oleic Acid, Stigmasterol, Beta-sitosterol, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. Kaempferol has biological action on biochemical pathways Hypoxia, PI3K-AKT-MTOR Signaling and MAPK Signaling.
Folic Acid can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. And so on.
For genetic risk of Systemic Mastocytosis due to abnormalities in genes CNOT3 and FLT3 – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF SYSTEMIC MASTOCYTOSIS DUE TO GENES CNOT3 AND FLT3
Eat more vegetables, Arugula or Celery?
The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Kaempferol, Luteolin, Vitamin C and others.
Kaempferol can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling and Stem Cell Signaling. Cynaroside has biological action on biochemical pathways MAPK Signaling and Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Systemic Mastocytosis due to abnormalities in genes CNOT3 and FLT3 – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF SYSTEMIC MASTOCYTOSIS DUE TO GENES CNOT3 AND FLT3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Cranberry?
The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Quercetagetin among others. While the active ingredients contained in Cranberry are Quercetin, Myricetin, Ellagic Acid, Resveratrol, Vitamin C and others.
D-limonene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways Hypoxia, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.
Myricetin can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Stem Cell Signaling. And so on.
For genetic risk of Systemic Mastocytosis due to abnormalities in genes CNOT3 and FLT3 – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Myricetin and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF SYSTEMIC MASTOCYTOSIS DUE TO GENES CNOT3 AND FLT3
Eat more nuts, Pistachio or Cashew Nut?
The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Vitamin K, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways RAS-RAF Signaling, JAK-STAT Signaling and Hypoxia.
Lauric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways mRNA Splicing, Oncogenic Cancer Epigenetics and MAPK Signaling. And so on.
For genetic risk of Systemic Mastocytosis due to abnormalities in genes CNOT3 and FLT3 – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Palmitic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SYSTEMIC MASTOCYTOSIS DUE TO GENES CNOT3 AND FLT3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Systemic Mastocytosis by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.