Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mucinous Cervical Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Mucinous Cervical Cancer because of NSD1 and PTCH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mucinous Cervical Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Heart Of Palm” or “Can I take Modified Citrus Pectin and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MUCINOUS CERVICAL CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mucinous Cervical Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MUCINOUS CERVICAL CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mucinous Cervical Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mucinous Cervical Cancer from cBioPortal. From a patient sample size of 6; the top genes with mutations and other abnormalities for Mucinous Cervical Cancer include genes KRAS, NSD1, PTCH1, RB1 and STK11. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Mucinous Cervical Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mucinous Cervical Cancer.
Significance of Nutrition for Mucinous Cervical Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mucinous Cervical Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cherry includes active ingredients Glucaric Acid, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid and others. And Orange contains active ingredients Modified Citrus Pectin, D-limonene, Linalool, Glucaric Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mucinous Cervical Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mucinous Cervical Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MUCINOUS CERVICAL CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mucinous Cervical Cancer undergoing chemotherapy treatment
In Mucinous Cervical Cancer – the genes KRAS, NSD1, PTCH1, RB1 and STK11 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mucinous Cervical Cancer are RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Black-eyed Pea?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Glucaric Acid, Quercetin, Vitamin C, Oleic Acid, Vitexin among others. While the active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Mucinous Cervical Cancer with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Beta-carotene and Folic Acid in Black-eyed Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR MUCINOUS CERVICAL CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Heart Of Palm?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Kaempferol can manipulate biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Mucinous Cervical Cancer with chemotherapy Radiation – Foods like Arugula are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER HEART OF PALM FOR MUCINOUS CERVICAL CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Orange or Cherry?
Fruits are an important part of many diets. The active ingredients contained in Orange are Modified Citrus Pectin, D-limonene, Linalool, Glucaric Acid, Vitamin C among others. While the active ingredients contained in Cherry are Glucaric Acid, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid and others.
D-limonene can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Shikimic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Mucinous Cervical Cancer with chemotherapy Radiation – Foods like Orange are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Glucaric Acid contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CHERRY FOR MUCINOUS CERVICAL CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Oleic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Mucinous Cervical Cancer with chemotherapy Radiation – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR MUCINOUS CERVICAL CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Mucinous Cervical Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NSD1 and PTCH1 are two genes whose abnormalities are risk factors for Mucinous Cervical Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mucinous Cervical Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Mucinous Cervical Cancer gene NSD1 has causative impact on biological pathways like Oncogenic Histone Methylation, Chromatin Remodeling and Amino Acid Metabolism. And PTCH1 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NSD1 and PTCH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NSD1 and PTCH1 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Beta-sitosterol, Genistein, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Oleic Acid, Beta-sitosterol, Genistein, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Genistein has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Mucinous Cervical Cancer due to abnormalities in genes NSD1 and PTCH1 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Genistein contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF MUCINOUS CERVICAL CANCER DUE TO GENES NSD1 AND PTCH1
Eat more vegetables, Giant Butterbur or Beetroot?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Beetroot are Oleic Acid, Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Apoptosis.
Vitamin E can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Mucinous Cervical Cancer due to abnormalities in genes NSD1 and PTCH1 – Foods like Giant Butterbur are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF MUCINOUS CERVICAL CANCER DUE TO GENES NSD1 AND PTCH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Partridgeberry or Huckleberry?
The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, P-coumaric Acid, Quercetin, Ferulic Acid and others.
Resveratrol can manipulate biochemical pathways Apoptosis, DNA Repair and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mucinous Cervical Cancer due to abnormalities in genes NSD1 and PTCH1 – Foods like Partridgeberry are recommended compared to Huckleberry. This is because the active ingredients Ferulic Acid and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF MUCINOUS CERVICAL CANCER DUE TO GENES NSD1 AND PTCH1
Eat more nuts, Hazelnut or Acorn?
The active ingredients contained in Hazelnut are Oleic Acid, Vitamin E, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Acorn are Beta-sitosterol, Vitamin C, Vitamin B3, Quercetin, Quercitrin and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Beta-carotene can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mucinous Cervical Cancer due to abnormalities in genes NSD1 and PTCH1 – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Gallic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF MUCINOUS CERVICAL CANCER DUE TO GENES NSD1 AND PTCH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mucinous Cervical Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
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- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.