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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Mixed Germ Cell Tumor?

Aug 23, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mixed Germ Cell Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Mixed Germ Cell Tumor because of RAC1 and DNMT1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Mixed Germ Cell Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Amentoflavone and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MIXED GERM CELL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Mixed Germ Cell Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MIXED GERM CELL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Mixed Germ Cell Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Mixed Germ Cell Tumor from cBioPortal. 97.9% of males and 2.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 311; the top genes with mutations and other abnormalities for Mixed Germ Cell Tumor include genes KRAS, RAC1, DNMT1, MTOR and XPO1. The occurrence frequency distribution for these genes respectively is 6.9%, 2.9%, 2.0%, 2.0% and 2.0%. These tumor genetic details of Mixed Germ Cell Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mixed Germ Cell Tumor.

Significance of Nutrition for Mixed Germ Cell Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mixed Germ Cell Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Resveratrol, Quercetin, Caffeic Acid, Vitamin C, Ferulic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Mixed Germ Cell Tumor, activation or inhibition of selected biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mixed Germ Cell Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Mixed Germ Cell Tumor, activation or inhibition of selected biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MIXED GERM CELL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Mixed Germ Cell Tumor undergoing chemotherapy treatment

In Mixed Germ Cell Tumor – the genes KRAS, RAC1, DNMT1, MTOR and XPO1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mixed Germ Cell Tumor are Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lentils?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Oleic Acid, Vitamin C among others. While the active ingredients contained in Lentils are Beta-sitosterol, Isoliquiritigenin, Daidzein, Ellagic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Microtubule Dynamics and MYC Signaling. And so on.

When treating Mixed Germ Cell Tumor with chemotherapy Fluorouracil – Foods like Common Pea are recommended compared to Lentils. This is because the active ingredients Isoliquiritigenin and Ellagic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LENTILS FOR MIXED GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Yam?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Yam are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Dioscin has biological action on biochemical pathways NFKB Signaling. And so on.

When treating Mixed Germ Cell Tumor with chemotherapy Fluorouracil – Foods like Cabbage are recommended compared to Yam. This is because the active ingredients Citric Acid and Dioscin in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER YAM FOR MIXED GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Which Foods are Recommended for Mixed Germ Cell Tumor?

Eat more fruits, Nance or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Caffeic Acid, Vitamin C, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Betulin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.

Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Mixed Germ Cell Tumor with chemotherapy Fluorouracil – Foods like Nance are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Quercetin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER HUCKLEBERRY FOR MIXED GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, MYC Signaling and P53 Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Mixed Germ Cell Tumor with chemotherapy Fluorouracil – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR MIXED GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Foods for Genetic Risk of Mixed Germ Cell Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RAC1 and DNMT1 are two genes whose abnormalities are risk factors for Mixed Germ Cell Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mixed Germ Cell Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Mixed Germ Cell Tumor gene RAC1 has causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and Angiogenesis. And DNMT1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Antigen Presentation and Immune Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RAC1 and DNMT1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RAC1 and DNMT1 should be avoided.

Eat more pulses, Winged Bean or Lima Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.

Betulinic Acid can manipulate biochemical pathways Oxidative Stress, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Mixed Germ Cell Tumor due to abnormalities in genes RAC1 and DNMT1 – Foods like Winged Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF MIXED GERM CELL TUMOR DUE TO GENES RAC1 AND DNMT1

Eat more vegetables, Giant Butterbur or Chinese Mustard?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Kaempferol, Melatonin, Vitamin B3 among others. While the active ingredients contained in Chinese Mustard are Quercetin, Isorhamnetin, Kaempferol, Indole-3-carbinol, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Oxidative Stress, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Cell Junctions and Oxidative Stress. And so on.

For genetic risk of Mixed Germ Cell Tumor due to abnormalities in genes RAC1 and DNMT1 – Foods like Giant Butterbur are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Quercetin in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF MIXED GERM CELL TUMOR DUE TO GENES RAC1 AND DNMT1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Partridgeberry or Pummelo?

The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Vitamin C, Oleic Acid, Naringin, Chlorogenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways Oxidative Stress, MAPK Signaling and MYC Signaling.

Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Mixed Germ Cell Tumor due to abnormalities in genes RAC1 and DNMT1 – Foods like Partridgeberry are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF MIXED GERM CELL TUMOR DUE TO GENES RAC1 AND DNMT1

Eat more nuts, Pine Nut or Cashew Nut?

The active ingredients contained in Pine Nut are Beta-sitosterol, Oleic Acid, Vitamin E, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Butyric Acid, Palmitic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, MAPK Signaling and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Mixed Germ Cell Tumor due to abnormalities in genes RAC1 and DNMT1 – Foods like Pine Nut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF MIXED GERM CELL TUMOR DUE TO GENES RAC1 AND DNMT1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Mixed Germ Cell Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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