Which Foods are Recommended for Intracholecystic Papillary Neoplasm?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Intracholecystic Papillary Neoplasm when undergoing chemotherapy or when you determine you have a genetic risk for developing Intracholecystic Papillary Neoplasm because of SMAD4 and SPOP gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Intracholecystic Papillary Neoplasm which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Andrographis and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INTRACHOLECYSTIC PAPILLARY NEOPLASM, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Intracholecystic Papillary Neoplasm is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Intracholecystic Papillary Neoplasm

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Intracholecystic Papillary Neoplasm from cBioPortal. The patients enrolled in the studies for Intracholecystic Papillary Neoplasm are in ages between 37 to 76 with an average age of 62. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 8; the top genes with mutations and other abnormalities for Intracholecystic Papillary Neoplasm include genes TP53, ARID1A, KMT2C, SMAD4 and SPOP. The occurrence frequency distribution for these genes respectively is 75.0%, 37.5%, 37.5%, 37.5% and 25.0%. These tumor genetic details of Intracholecystic Papillary Neoplasm are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Intracholecystic Papillary Neoplasm.

Significance of Nutrition for Intracholecystic Papillary Neoplasm

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Intracholecystic Papillary Neoplasm. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Bilberry includes active ingredients Quercetin, Caffeic Acid, P-coumaric Acid, Resveratrol, Gallic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Intracholecystic Papillary Neoplasm, activation or inhibition of selected biochemical pathways like Cell Cycle, Notch Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Intracholecystic Papillary Neoplasm, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Intracholecystic Papillary Neoplasm undergoing chemotherapy treatment

In Intracholecystic Papillary Neoplasm – the genes TP53, ARID1A, KMT2C, SMAD4 and SPOP have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Intracholecystic Papillary Neoplasm are Cell Cycle, Notch Signaling, Cell Cycle Checkpoints and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Notch Signaling, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Inositol Phosphate Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.

Genistein can manipulate biochemical pathways DNA Repair, Nutrient sensing and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intracholecystic Papillary Neoplasm with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Cauliflower?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Beta-sitosterol, Quercetin, Vitamin C, Caffeic Acid, Linolenic Acid among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Vitamin C, Brassinin, Linolenic Acid, Oleic Acid and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intracholecystic Papillary Neoplasm with chemotherapy Cisplatin – Foods like Lettuce are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER CAULIFLOWER FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more fruits, Nance or Bilberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Bilberry are Quercetin, Caffeic Acid, P-coumaric Acid, Resveratrol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Betulin has biological action on biochemical pathways MYC Signaling, Nutrient sensing and MAPK Signaling.

Arbutin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intracholecystic Papillary Neoplasm with chemotherapy Cisplatin – Foods like Nance are recommended compared to Bilberry. This is because the active ingredients Arbutin and Chlorogenic Acid in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER BILBERRY FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Inositol Phosphate Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intracholecystic Papillary Neoplasm with chemotherapy Cisplatin – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR INTRACHOLECYSTIC PAPILLARY NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Intracholecystic Papillary Neoplasm

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMAD4 and SPOP are two genes whose abnormalities are risk factors for Intracholecystic Papillary Neoplasm. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Intracholecystic Papillary Neoplasm can be used as a guide for coming up with a recommended personalized nutrition plan. For Intracholecystic Papillary Neoplasm gene SMAD4 has causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. And SPOP has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMAD4 and SPOP should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMAD4 and SPOP should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Vitamin C, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Intracholecystic Papillary Neoplasm due to abnormalities in genes SMAD4 and SPOP – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF INTRACHOLECYSTIC PAPILLARY NEOPLASM DUE TO GENES SMAD4 AND SPOP

Eat more vegetables, Jicama or Bell Pepper?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, Linolenic Acid, Capsaicin, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Intracholecystic Papillary Neoplasm due to abnormalities in genes SMAD4 and SPOP – Foods like Jicama are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF INTRACHOLECYSTIC PAPILLARY NEOPLASM DUE TO GENES SMAD4 AND SPOP

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Vitamin C, Resveratrol, Hyperoside, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Intracholecystic Papillary Neoplasm due to abnormalities in genes SMAD4 and SPOP – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF INTRACHOLECYSTIC PAPILLARY NEOPLASM DUE TO GENES SMAD4 AND SPOP

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Vitamin C, Beta-sitosterol, Linolenic Acid, Rhamnetin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Intracholecystic Papillary Neoplasm due to abnormalities in genes SMAD4 and SPOP – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF INTRACHOLECYSTIC PAPILLARY NEOPLASM DUE TO GENES SMAD4 AND SPOP

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Intracholecystic Papillary Neoplasm by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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