Foods for Gallbladder Neuroendocrine Tumor!

Introduction

Foods for Gallbladder Neuroendocrine Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Gallbladder Neuroendocrine Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Gallbladder Neuroendocrine Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Gallbladder Neuroendocrine Tumor?

For example does it matter if vegetable Pepper (capsicum) is consumed more compared to Swamp Cabbage? Does it make any difference if fruit Grapefruit is preferred over Java Plum? Also if similar choices are made for nuts/seeds like Chia over Chinese Chestnut and for pulses like White Lupine over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Gallbladder Neuroendocrine Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Gallbladder Neuroendocrine Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Catechol, Curcumin, Naringin, Lupeol, Phloretin. And Java Plum contains active ingredients Catechol, Curcumin, Lupeol, Phloretin, Beta-sitosterol and possibly others.

A common mistake made when deciding and choosing foods to eat for Gallbladder Neuroendocrine Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Gallbladder Neuroendocrine Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Gallbladder Neuroendocrine Tumor?

Personalized nutrition for cancers like Gallbladder Neuroendocrine Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Gallbladder Neuroendocrine Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Gallbladder Neuroendocrine Tumor

All cancers like Gallbladder Neuroendocrine Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Gallbladder Neuroendocrine Tumor. Biochemical pathways like Angiogenesis, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Gallbladder Neuroendocrine Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Gallbladder Neuroendocrine Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Gallbladder Neuroendocrine Tumor when taking cancer treatment Ramucirumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, SMARCB1, FANCM, ERBB2 and CTNNB1 are the top ranked reported genes for Gallbladder Neuroendocrine Tumor. TP53 is reported in 100.0 % of the representative patients across all clinical trials. And SMARCB1 is reported in 25.0 %. The combined population patient data cover ages from to . 83.3 % of the patient data are identified as men. The Gallbladder Neuroendocrine Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Gallbladder Neuroendocrine Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable PEPPER (CAPSICUM) or SWAMP CABBAGE?

Vegetable Pepper (capsicum) contains many active ingredients or bioactives such as Catechol, Curcumin, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Angiogenesis, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Pepper (capsicum) is recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab. This is because Pepper (capsicum) modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ramucirumab.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Catechol, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Swamp Cabbage is not recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE PEPPER (CAPSICUM) IS RECOMMENDED OVER SWAMP CABBAGE FOR Gallbladder Neuroendocrine Tumor AND TREATMENT Ramucirumab.

Choose Fruit JAVA PLUM or GRAPEFRUIT?

Fruit Java Plum contains many active ingredients or bioactives such as Catechol, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MYC Signaling, Angiogenesis, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab. This is because Java Plum modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ramucirumab.

Some of the active ingredients or bioactives in fruit Grapefruit are Catechol, Curcumin, Naringin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Grapefruit is not recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT JAVA PLUM IS RECOMMENDED OVER GRAPEFRUIT FOR Gallbladder Neuroendocrine Tumor AND TREATMENT Ramucirumab.

Choose Nut CHIA or CHINESE CHESTNUT?

Chia contains many active ingredients or bioactives such as Catechol, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Chia is recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ramucirumab.

Some of the active ingredients or bioactives in Chinese Chestnut are Catechol, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Chinese Chestnut is not recommended for Gallbladder Neuroendocrine Tumor when ongoing cancer treatment is Ramucirumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER CHINESE CHESTNUT FOR Gallbladder Neuroendocrine Tumor AND TREATMENT Ramucirumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Gallbladder Neuroendocrine Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or RADISH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Radish are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Radish is not recommended when risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR CTNNB1 GENETIC RISK OF CANCER.

Choose Fruit EUROPEAN CRANBERRY or ELDERBERRY?

Fruit European Cranberry contains many active ingredients or bioactives such as Curcumin, Apigenin, Ellagic Acid, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. European Cranberry is recommended for risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1. This is because European Cranberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Elderberry are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and Stem Cell Signaling and others. Elderberry is not recommended when risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER ELDERBERRY FOR CTNNB1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and Stem Cell Signaling and others. Chestnut is not recommended when risk of Gallbladder Neuroendocrine Tumor when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR CTNNB1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Gallbladder Neuroendocrine Tumor. Gallbladder Neuroendocrine Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Gallbladder Neuroendocrine Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Pepper (capsicum) contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Gallbladder Neuroendocrine Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
• Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway.
• Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
• Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice.