Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gallbladder Neuroendocrine Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Gallbladder Neuroendocrine Tumor because of SMARCB1 and FANCM gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Gallbladder Neuroendocrine Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Birch and Chaga Mushroom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GALLBLADDER NEUROENDOCRINE TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Gallbladder Neuroendocrine Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GALLBLADDER NEUROENDOCRINE TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Gallbladder Neuroendocrine Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Gallbladder Neuroendocrine Tumor from cBioPortal. 83.3% of males and 16.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 6; the top genes with mutations and other abnormalities for Gallbladder Neuroendocrine Tumor include genes TP53, SMARCB1, FANCM, ERBB2 and CTNNB1. The occurrence frequency distribution for these genes respectively is 100.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Gallbladder Neuroendocrine Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gallbladder Neuroendocrine Tumor.
Significance of Nutrition for Gallbladder Neuroendocrine Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gallbladder Neuroendocrine Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Resveratrol, Quercetin, Ellagic Acid, Hyperoside, Vitamin C and others. And Persimmon contains active ingredients Betulinic Acid, Lupeol, Quercetin, Lycopene, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Gallbladder Neuroendocrine Tumor, activation or inhibition of selected biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gallbladder Neuroendocrine Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GALLBLADDER NEUROENDOCRINE TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Gallbladder Neuroendocrine Tumor undergoing chemotherapy treatment
In Gallbladder Neuroendocrine Tumor – the genes TP53, SMARCB1, FANCM, ERBB2 and CTNNB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gallbladder Neuroendocrine Tumor are Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Survival. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Angiogenesis and Epithelial to Mesenchymal Transition. And so on.
When treating Gallbladder Neuroendocrine Tumor with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR GALLBLADDER NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Chayote?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Chayote are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Kaempferol has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and Angiogenesis.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Angiogenesis and Epithelial to Mesenchymal Transition. And so on.
When treating Gallbladder Neuroendocrine Tumor with chemotherapy Doxorubicin – Foods like Arugula are recommended compared to Chayote. This is because the active ingredients Oleic Acid and Linoleic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHAYOTE FOR GALLBLADDER NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Betulinic Acid, Lupeol, Quercetin, Lycopene, Vitamin C among others. While the active ingredients contained in Cranberry are Resveratrol, Quercetin, Ellagic Acid, Hyperoside, Vitamin C and others.
Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Survival. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.
When treating Gallbladder Neuroendocrine Tumor with chemotherapy Doxorubicin – Foods like Persimmon are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER CRANBERRY FOR GALLBLADDER NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Survival. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Gallbladder Neuroendocrine Tumor with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR GALLBLADDER NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Gallbladder Neuroendocrine Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCB1 and FANCM are two genes whose abnormalities are risk factors for Gallbladder Neuroendocrine Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gallbladder Neuroendocrine Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Gallbladder Neuroendocrine Tumor gene SMARCB1 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And FANCM has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCB1 and FANCM should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCB1 and FANCM should be avoided.
Eat more pulses, Winged Bean or Moth Bean?
The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Moth Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.
Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Gallbladder Neuroendocrine Tumor due to abnormalities in genes SMARCB1 and FANCM – Foods like Winged Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF GALLBLADDER NEUROENDOCRINE TUMOR DUE TO GENES SMARCB1 AND FANCM
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Quercetin, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Gallbladder Neuroendocrine Tumor due to abnormalities in genes SMARCB1 and FANCM – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF GALLBLADDER NEUROENDOCRINE TUMOR DUE TO GENES SMARCB1 AND FANCM
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Currant or Sea Buckthorn?
The active ingredients contained in Currant are Cianidanol, Delphinidin, Oleic Acid, Quercetin, Gamma-linolenic Acid among others. While the active ingredients contained in Sea Buckthorn are Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol, Isorhamnetin and others.
Cianidanol can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Growth Factor Signaling.
Isorhamnetin can manipulate biochemical pathways Small Molecule Transport. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Gallbladder Neuroendocrine Tumor due to abnormalities in genes SMARCB1 and FANCM – Foods like Currant are recommended compared to Sea Buckthorn. This is because the active ingredients Isorhamnetin and Linoleic Acid in Sea Buckthorn further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Currant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER SEA BUCKTHORN FOR REDUCING THE GENETIC RISK OF GALLBLADDER NEUROENDOCRINE TUMOR DUE TO GENES SMARCB1 AND FANCM
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Oleic Acid, Quercetin, Gamma-linolenic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Gallbladder Neuroendocrine Tumor due to abnormalities in genes SMARCB1 and FANCM – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GALLBLADDER NEUROENDOCRINE TUMOR DUE TO GENES SMARCB1 AND FANCM
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Gallbladder Neuroendocrine Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.