Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Stomach Signet Ring Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Stomach Signet Ring Cell Carcinoma because of CDH10 and SMARCA4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Stomach Signet Ring Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Blackberry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO STOMACH SIGNET RING CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Stomach Signet Ring Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR STOMACH SIGNET RING CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Stomach Signet Ring Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Stomach Signet Ring Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Stomach Signet Ring Cell Carcinoma are in ages between 46 to 77 with an average age of 66. 47.6% of males and 52.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Stomach Signet Ring Cell Carcinoma include genes CDH10, MUC16, SMARCA4, PLK1 and BCOR. The occurrence frequency distribution for these genes respectively is 20.0%, 20.0%, 20.0%, 20.0% and 20.0%. These tumor genetic details of Stomach Signet Ring Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Stomach Signet Ring Cell Carcinoma.
Significance of Nutrition for Stomach Signet Ring Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Stomach Signet Ring Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Blackberry includes active ingredients Quercetin, Ellagic Acid, Kaempferol, Myricetin, Cianidanol and others. And Pomegranate contains active ingredients Apigenin, Ellagic Acid, Beta-sitosterol, Betulinic Acid, Corilagin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Stomach Signet Ring Cell Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Stomach Signet Ring Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR STOMACH SIGNET RING CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Stomach Signet Ring Cell Carcinoma undergoing chemotherapy treatment
In Stomach Signet Ring Cell Carcinoma – the genes CDH10, MUC16, SMARCA4, PLK1 and BCOR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Stomach Signet Ring Cell Carcinoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Kaempferol among others. While the active ingredients contained in Yellow Wax Bean are Butyric Acid, Vitamin C, Cianidanol, Ferulic Acid, Palmitic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Chromatin Remodeling. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and WNT Beta Catenin Signaling. Astragalin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Stomach Signet Ring Cell Carcinoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Astragalin in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR STOMACH SIGNET RING CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Lettuce or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Linolenic Acid, Vitamin E, Vitamin C, Oleic Acid and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Oncogenic Cancer Epigenetics. Linoleic Acid has biological action on biochemical pathways Angiogenesis and Epithelial to Mesenchymal Transition. And so on.
When treating Stomach Signet Ring Cell Carcinoma with chemotherapy Doxorubicin – Foods like Lettuce are recommended compared to Beetroot. This is because the active ingredients Oleic Acid and Linoleic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: LETTUCE IS RECOMMENDED OVER BEETROOT FOR STOMACH SIGNET RING CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Blackberry?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Ellagic Acid, Beta-sitosterol, Betulinic Acid, Corilagin among others. While the active ingredients contained in Blackberry are Quercetin, Ellagic Acid, Kaempferol, Myricetin, Cianidanol and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and JAK-STAT Signaling. Ursolic Acid has biological action on biochemical pathways Chromatin Remodeling, MYC Signaling and P53 Signaling.
Scopoletin can manipulate biochemical pathways Chromatin Remodeling and Oncogenic Cancer Epigenetics. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.
When treating Stomach Signet Ring Cell Carcinoma with chemotherapy Doxorubicin – Foods like Pomegranate are recommended compared to Blackberry. This is because the active ingredients Scopoletin and Ellagic Acid in Blackberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Ursolic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER BLACKBERRY FOR STOMACH SIGNET RING CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Linolenic Acid, Vitamin E, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Linolenic Acid, Vitamin C, Oleic Acid and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Growth Factor Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Epithelial to Mesenchymal Transition. And so on.
When treating Stomach Signet Ring Cell Carcinoma with chemotherapy Doxorubicin – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR STOMACH SIGNET RING CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Stomach Signet Ring Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDH10 and SMARCA4 are two genes whose abnormalities are risk factors for Stomach Signet Ring Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Stomach Signet Ring Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Stomach Signet Ring Cell Carcinoma gene CDH10 has causative impact on biological pathways like Adherens junction. And SMARCA4 has a causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDH10 and SMARCA4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDH10 and SMARCA4 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Stomach Signet Ring Cell Carcinoma due to abnormalities in genes CDH10 and SMARCA4 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF STOMACH SIGNET RING CELL CARCINOMA DUE TO GENES CDH10 AND SMARCA4
Eat more vegetables, Cassava or Chayote?
The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Chayote are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Stomach Signet Ring Cell Carcinoma due to abnormalities in genes CDH10 and SMARCA4 – Foods like Cassava are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF STOMACH SIGNET RING CELL CARCINOMA DUE TO GENES CDH10 AND SMARCA4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Peach?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Epicatechin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Stomach Signet Ring Cell Carcinoma due to abnormalities in genes CDH10 and SMARCA4 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF STOMACH SIGNET RING CELL CARCINOMA DUE TO GENES CDH10 AND SMARCA4
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Peanut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair and Growth Factor Signaling. And so on.
For genetic risk of Stomach Signet Ring Cell Carcinoma due to abnormalities in genes CDH10 and SMARCA4 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF STOMACH SIGNET RING CELL CARCINOMA DUE TO GENES CDH10 AND SMARCA4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Stomach Signet Ring Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pancan Pcawg 2020
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- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.