Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Poems Syndrome when undergoing chemotherapy or when you determine you have a genetic risk for developing Poems Syndrome because of LATS2 and CYSLTR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Poems Syndrome which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Green Bean” or “Can I take Caffeine and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO POEMS SYNDROME, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Poems Syndrome is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR POEMS SYNDROME, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Poems Syndrome
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Poems Syndrome from cBioPortal. The top genes with mutations and other abnormalities for Poems Syndrome include genes LATS2, CYSLTR2, IRS2, CUL4A and ERCC5. The occurrence frequency distribution for these genes respectively is 50.41176471%, 50.41176471%, 50.41176471%, 50.41176471% and 50.41176471%. These tumor genetic details of Poems Syndrome are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Poems Syndrome.
POEMS is an acronym that stands for the five major signs and symptoms of this syndrome which include Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin abnormalities. It is an extremely rare syndrome that is caused by an abnormal immune response by the body to a cancerous tumor, in which the body accidently attacks normal cells in the nervous system. Studies have reported abnormally high levels of vascular endothelial growth factor (VEGF) and pro-inflammatory cytokines in the blood of individuals with POEMS syndrome. POEMS syndrome occurs 1.5 times more frequently among men than women and more commonly occurs in adults in their 50s. Common symptoms of POEMS syndrome include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and / or spleen, enlarged lymph nodes, darkening of the skin, thickening of the skin and excessive hair growth. POEMS syndrome is a chronic disorder, and its prognosis depends on the extent of the disease and the individuals’ response to treatment. There is no standard treatment for POEMS syndrome. Treatment options include radiation therapy, chemotherapy, immune modulatory or hematopoietic cell transplant. The median survival for patients with POEMS syndrome is more than 14 years. Supportive care with the right nutrition (foods and natural supplements) can also help improve the patients’ well-being. (Ref: https://rarediseases.org/rare-diseases/poems-syndrome/; https://www.mayoclinic.org/diseases-conditions/poems-syndrome/symptoms-causes/syc-20352678; https://my.clevelandclinic.org/health/diseases/17985-poems-syndrome )
Significance of Nutrition for Poems Syndrome
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Poems Syndrome. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Bilberry includes active ingredients Myricetin, Quercetin, Resveratrol, Caffeic Acid, Gallic Acid and others. And Raspberry contains active ingredients Ellagic Acid, Quercetin, Resveratrol, Gallic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Poems Syndrome, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, Cytokine Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Poems Syndrome, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR POEMS SYNDROME – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Poems Syndrome undergoing chemotherapy treatment
In Poems Syndrome – the genes LATS2, CYSLTR2, IRS2, CUL4A and ERCC5 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Poems Syndrome are Extracellular Matrix Remodelling, Cytokine Signaling, DNA Repair and others. Melphalan is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Extracellular Matrix Remodelling, Cytokine Signaling, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Oleic Acid, Daidzein, Lupeol, Kaempferol, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Linoleic Acid, Vitamin C, Genistein, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cytokine Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Poems Syndrome with chemotherapy Melphalan – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR POEMS SYNDROME ON TREATMENT WITH CHEMOTHERAPY MELPHALAN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Green Bean?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Kaempferol, Brassinin among others. While the active ingredients contained in Green Bean are Oleic Acid, Kaempferol, Linolenic Acid, Linoleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Cytokine Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Poems Syndrome with chemotherapy Melphalan – Foods like Cabbage are recommended compared to Green Bean. This is because the active ingredients Vitamin A and Citric Acid in Green Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER GREEN BEAN FOR POEMS SYNDROME ON TREATMENT WITH CHEMOTHERAPY MELPHALAN FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Bilberry?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Gallic Acid, Vitamin C among others. While the active ingredients contained in Bilberry are Myricetin, Quercetin, Resveratrol, Caffeic Acid, Gallic Acid and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Chlorogenic Acid can manipulate biochemical pathways Oxidative Stress. Delphinidin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Poems Syndrome with chemotherapy Melphalan – Foods like Raspberry are recommended compared to Bilberry. This is because the active ingredients Chlorogenic Acid and Delphinidin in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER BILBERRY FOR POEMS SYNDROME ON TREATMENT WITH CHEMOTHERAPY MELPHALAN FOR SOME CONDITIONS.
Eat more nuts, Walnut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Myricetin, Ellagic Acid, Quercetin, D-limonene, Vitamin E among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Gamma-linolenic Acid, Linolenic Acid, Linoleic Acid, Stigmasterol and others.
Myricetin can manipulate biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling. Ellagic Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Cytokine Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Poems Syndrome with chemotherapy Melphalan – Foods like Walnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Myricetin and Ellagic Acid contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR POEMS SYNDROME ON TREATMENT WITH CHEMOTHERAPY MELPHALAN FOR SOME CONDITIONS.
Foods for Genetic Risk of Poems Syndrome
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LATS2 and CYSLTR2 are two genes whose abnormalities are risk factors for Poems Syndrome. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Poems Syndrome can be used as a guide for coming up with a recommended personalized nutrition plan. For Poems Syndrome gene LATS2 has causative impact on biological pathways like Hippo Signaling. And CYSLTR2 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LATS2 and CYSLTR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LATS2 and CYSLTR2 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.
For genetic risk of Poems Syndrome due to abnormalities in genes LATS2 and CYSLTR2 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF POEMS SYNDROME DUE TO GENES LATS2 AND CYSLTR2
Eat more vegetables, Mexican Groundcherry or Chinese Mustard?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Chinese Mustard are Quercetin, Kaempferol, Indole-3-carbinol, Isorhamnetin, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways FOXO Signaling, DNA Repair and Hypoxia.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Poems Syndrome due to abnormalities in genes LATS2 and CYSLTR2 – Foods like Mexican Groundcherry are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Quercetin in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF POEMS SYNDROME DUE TO GENES LATS2 AND CYSLTR2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Partridgeberry or Peach?
The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Peach are Kaempferol, Modified Citrus Pectin, Oleic Acid, Linolenic Acid, Vitamin C and others.
Resveratrol can manipulate biochemical pathways Hippo Signaling, DNA Repair and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Poems Syndrome due to abnormalities in genes LATS2 and CYSLTR2 – Foods like Partridgeberry are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF POEMS SYNDROME DUE TO GENES LATS2 AND CYSLTR2
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Oleic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol, Vitamin K among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Vitamin B3, Gallic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Poems Syndrome due to abnormalities in genes LATS2 and CYSLTR2 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF POEMS SYNDROME DUE TO GENES LATS2 AND CYSLTR2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Poems Syndrome by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
- Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
- Research on Rett syndrome: strategy and preliminary results.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Role of FoxO1 in FFA-induced oxidative stress in adipocytes.
- Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Research progress on the anticancer effects of vitamin K2.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.