Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Paranasal Sinus And Nasal Cavity Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Paranasal Sinus And Nasal Cavity Cancer because of ERCC1 and POLH gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Paranasal Sinus And Nasal Cavity Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Squash” or “Can I take Mulberry and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PARANASAL SINUS AND NASAL CAVITY CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Paranasal Sinus And Nasal Cavity Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PARANASAL SINUS AND NASAL CAVITY CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Paranasal Sinus And Nasal Cavity Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Paranasal Sinus And Nasal Cavity Cancer from cBioPortal. The top genes with mutations and other abnormalities for Paranasal Sinus And Nasal Cavity Cancer include genes TP53, ERCC1, POLH, XRCC1 and PTPN14. The occurrence frequency distribution for these genes respectively is 32.4%, 22.2%, 20.0%, 20.0% and 20.0%. These tumor genetic details of Paranasal Sinus And Nasal Cavity Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Paranasal Sinus And Nasal Cavity Cancer.
Significance of Nutrition for Paranasal Sinus And Nasal Cavity Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Paranasal Sinus And Nasal Cavity Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Quercetin, Resveratrol, Hyperoside, Vitamin C, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Paranasal Sinus And Nasal Cavity Cancer, activation or inhibition of selected biochemical pathways like Apoptosis, Nutrient sensing, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Paranasal Sinus And Nasal Cavity Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PARANASAL SINUS AND NASAL CAVITY CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Paranasal Sinus And Nasal Cavity Cancer undergoing chemotherapy treatment
In Paranasal Sinus And Nasal Cavity Cancer – the genes TP53, ERCC1, POLH, XRCC1 and PTPN14 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Paranasal Sinus And Nasal Cavity Cancer are Apoptosis, Nutrient sensing, RAS-RAF Signaling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Nutrient sensing, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, Growth Factor Signaling and Cell Cycle.
Genistein can manipulate biochemical pathways Nutrient sensing. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Paranasal Sinus And Nasal Cavity Cancer with chemotherapy Docetaxel – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR PARANASAL SINUS AND NASAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Squash?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Brassinin, Vitamin C, Indole-3-carbinol, Linolenic Acid among others. While the active ingredients contained in Squash are Ellagic Acid, Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, Growth Factor Signaling and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Paranasal Sinus And Nasal Cavity Cancer with chemotherapy Docetaxel – Foods like Kohlrabi are recommended compared to Squash. This is because the active ingredients Ellagic Acid and Vitamin A in Squash interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER SQUASH FOR PARANASAL SINUS AND NASAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Lingonberry are Quercetin, Resveratrol, Hyperoside, Vitamin C, Linolenic Acid and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Hippo Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Cell Cycle.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Paranasal Sinus And Nasal Cavity Cancer with chemotherapy Docetaxel – Foods like Partridgeberry are recommended compared to Lingonberry. This is because the active ingredients Caffeic Acid and Vitamin A in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER LINGONBERRY FOR PARANASAL SINUS AND NASAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Delphinidin, Oleic Acid, Cianidanol among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and Nutrient sensing.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Paranasal Sinus And Nasal Cavity Cancer with chemotherapy Docetaxel – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR PARANASAL SINUS AND NASAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Foods for Genetic Risk of Paranasal Sinus And Nasal Cavity Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERCC1 and POLH are two genes whose abnormalities are risk factors for Paranasal Sinus And Nasal Cavity Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Paranasal Sinus And Nasal Cavity Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Paranasal Sinus And Nasal Cavity Cancer gene ERCC1 has causative impact on biological pathways like DNA Repair and Chromatin Remodeling. And POLH has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERCC1 and POLH should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERCC1 and POLH should be avoided.
Eat more pulses, Scarlet Bean or Chickpea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Oleic Acid can manipulate biochemical pathways DNA Repair. Linolenic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Paranasal Sinus And Nasal Cavity Cancer due to abnormalities in genes ERCC1 and POLH – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Oleic Acid and Linolenic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF PARANASAL SINUS AND NASAL CAVITY CANCER DUE TO GENES ERCC1 AND POLH
Eat more vegetables, Mexican Groundcherry or Swede?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linoleic Acid, Linolenic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways DNA Repair, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways DNA Repair. Linolenic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Paranasal Sinus And Nasal Cavity Cancer due to abnormalities in genes ERCC1 and POLH – Foods like Mexican Groundcherry are recommended compared to Swede. This is because the active ingredients Oleic Acid and Linolenic Acid in Swede further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER SWEDE FOR REDUCING THE GENETIC RISK OF PARANASAL SINUS AND NASAL CAVITY CANCER DUE TO GENES ERCC1 AND POLH
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Graviola or Elderberry?
The active ingredients contained in Graviola are Emodin, Daidzein, Vitamin E, Lycopene, Beta-sitosterol among others. While the active ingredients contained in Elderberry are Lupeol, Betulinic Acid, Vitamin C, Oleic Acid, Isorhamnetin and others.
Emodin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cinnamic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Rutin can manipulate biochemical pathways DNA Repair. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Paranasal Sinus And Nasal Cavity Cancer due to abnormalities in genes ERCC1 and POLH – Foods like Graviola are recommended compared to Elderberry. This is because the active ingredients Rutin and Quercetin in Elderberry further promote the effects of genes on the biochemical pathways. While the active ingredients Emodin and Cinnamic Acid contained in Graviola together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER ELDERBERRY FOR REDUCING THE GENETIC RISK OF PARANASAL SINUS AND NASAL CAVITY CANCER DUE TO GENES ERCC1 AND POLH
Eat more nuts, Hazelnut or Macadamia Nut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linoleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Paranasal Sinus And Nasal Cavity Cancer due to abnormalities in genes ERCC1 and POLH – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF PARANASAL SINUS AND NASAL CAVITY CANCER DUE TO GENES ERCC1 AND POLH
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Paranasal Sinus And Nasal Cavity Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
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- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.