Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Splenic Marginal Zone Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Splenic Marginal Zone Lymphoma because of NOTCH2 and TNFAIP3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Splenic Marginal Zone Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Agaricus Mushroom and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SPLENIC MARGINAL ZONE LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Splenic Marginal Zone Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SPLENIC MARGINAL ZONE LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Splenic Marginal Zone Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Splenic Marginal Zone Lymphoma from cBioPortal. The top genes with mutations and other abnormalities for Splenic Marginal Zone Lymphoma include genes NOTCH2, TP53, TNFAIP3, MYD88 and SPEN. The occurrence frequency distribution for these genes respectively is 23.5%, 11.7%, 11.3%, 8.3% and 5.6%. These tumor genetic details of Splenic Marginal Zone Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Splenic Marginal Zone Lymphoma.
Significance of Nutrition for Splenic Marginal Zone Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Splenic Marginal Zone Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Modified Citrus Pectin, Linolenic Acid, Salicylic Acid, Beta-sitosterol and others. And Pomegranate contains active ingredients Ellagic Acid, Apigenin, Ursolic Acid, Pelargonidin, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Splenic Marginal Zone Lymphoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, NFKB Signaling, Notch Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Splenic Marginal Zone Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SPLENIC MARGINAL ZONE LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Splenic Marginal Zone Lymphoma undergoing chemotherapy treatment
In Splenic Marginal Zone Lymphoma – the genes NOTCH2, TP53, TNFAIP3, MYD88 and SPEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Splenic Marginal Zone Lymphoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling, Microtubule Dynamics and others. Cytarabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, Microtubule Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Genistein, Daidzein, Delphinidin, Kaempferol, Lupeol among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Beta-sitosterol, Oleic Acid, Stigmasterol, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways NFKB Signaling and Oncogenic Cancer Epigenetics. And so on.
When treating Splenic Marginal Zone Lymphoma with chemotherapy Cytarabine – Foods like Common Pea are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Oleic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER MOTH BEAN FOR SPLENIC MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more vegetables, Amaranth or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Amaranth are Linolenic Acid, Beta-sitosterol, Oleic Acid, Stigmasterol, Vitamin C among others. While the active ingredients contained in Chicory are Quercetin, Apigenin, Caffeic Acid, Protocatechuic Acid, Delphinidin and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways TWEAK Signaling. And so on.
When treating Splenic Marginal Zone Lymphoma with chemotherapy Cytarabine – Foods like Amaranth are recommended compared to Chicory. This is because the active ingredients Vitamin A and Apigenin in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: AMARANTH IS RECOMMENDED OVER CHICORY FOR SPLENIC MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Ellagic Acid, Apigenin, Ursolic Acid, Pelargonidin, Gallic Acid among others. While the active ingredients contained in Apricot are Quercetin, Modified Citrus Pectin, Linolenic Acid, Salicylic Acid, Beta-sitosterol and others.
Ursolic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Gallic Acid has biological action on biochemical pathways TWEAK Signaling, MYC Signaling and MAPK Signaling.
Rutin can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Microtubule Dynamics. Salicylic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Splenic Marginal Zone Lymphoma with chemotherapy Cytarabine – Foods like Pomegranate are recommended compared to Apricot. This is because the active ingredients Rutin and Salicylic Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ursolic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER APRICOT FOR SPLENIC MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Vitamin B3, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and TWEAK Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Splenic Marginal Zone Lymphoma with chemotherapy Cytarabine – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR SPLENIC MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Splenic Marginal Zone Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH2 and TNFAIP3 are two genes whose abnormalities are risk factors for Splenic Marginal Zone Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Splenic Marginal Zone Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Splenic Marginal Zone Lymphoma gene NOTCH2 has causative impact on biological pathways like Notch Signaling and Thyroid Hormone Signaling. And TNFAIP3 has a causative impact on biological pathways like Cytokine Signaling, Antigen Presentation and NFKB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH2 and TNFAIP3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH2 and TNFAIP3 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Genistein and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Splenic Marginal Zone Lymphoma due to abnormalities in genes NOTCH2 and TNFAIP3 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SPLENIC MARGINAL ZONE LYMPHOMA DUE TO GENES NOTCH2 AND TNFAIP3
Eat more vegetables, Giant Butterbur or Green Bean?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Green Bean are Beta-sitosterol, Linolenic Acid, Ferulic Acid, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Splenic Marginal Zone Lymphoma due to abnormalities in genes NOTCH2 and TNFAIP3 – Foods like Giant Butterbur are recommended compared to Green Bean. This is because the active ingredients Vitamin A and Folic Acid in Green Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER GREEN BEAN FOR REDUCING THE GENETIC RISK OF SPLENIC MARGINAL ZONE LYMPHOMA DUE TO GENES NOTCH2 AND TNFAIP3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Naranjilla?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Splenic Marginal Zone Lymphoma due to abnormalities in genes NOTCH2 and TNFAIP3 – Foods like Kiwi are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER NARANJILLA FOR REDUCING THE GENETIC RISK OF SPLENIC MARGINAL ZONE LYMPHOMA DUE TO GENES NOTCH2 AND TNFAIP3
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Beta-sitosterol, Vitamin E, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin E, Linolenic Acid, Ferulic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Splenic Marginal Zone Lymphoma due to abnormalities in genes NOTCH2 and TNFAIP3 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SPLENIC MARGINAL ZONE LYMPHOMA DUE TO GENES NOTCH2 AND TNFAIP3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Splenic Marginal Zone Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.