Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Meningioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Meningioma because of NF2 and ASXL1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Meningioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Persimmon in my diet” or “Can I take Eleuthero and Forsythia supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MENINGIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Meningioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MENINGIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Meningioma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Meningioma from cBioPortal. The patients enrolled in the studies for Meningioma are in ages between 10 to 83 with an average age of 57. 40.4% of males and 59.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 89; the top genes with mutations and other abnormalities for Meningioma include genes DNMT3A, TET2, NF2, TERT and ASXL1. The occurrence frequency distribution for these genes respectively is 46.2%, 15.4%, 7.7%, 7.7% and 7.7%. These tumor genetic details of Meningioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Meningioma.
Meningioma is the most common type of tumor that forms in the head, a tumor that arises from the membranes (meninges), that surround the brain and spinal cord. Although it is not a brain tumor, it is included in this category since it may compress or squeeze the adjacent brain, nerves, and vessels. The incidence rate of meningiomas is about 8.6 per 100,000 people. Majority of Meningiomas are benign, with 1.7% confirmed to be malignant. Meningiomas grow very slowly over many years without causing any symptoms, but sometimes their impact on the nearby brain tissue, nerves or vessels may cause serious disability. Meningiomas occur more commonly in women and are often discovered at older ages. Signs and symptoms of meningioma that may develop gradually include changes in vision such as double vision or blurriness, headaches, especially those that are worse in the morning, hearing loss or ringing in the ears, memory loss, loss of smell, seizures, weakness in arms or legs, language difficulty. Meningioma can be treated by surgery, radiation, or chemotherapy. The 10-year survival rate of non-malignant meningiomas is 84% while individuals with malignant meningioma have a 10-year survival rate of 62%. Treatment supported by the right nutrition (foods and supplements) can enhance the patient’s well-being. (Ref: https://www.mayoclinic.org/diseases-conditions/meningioma/symptoms-causes/syc-20355643; https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Meningiomas)
Significance of Nutrition for Meningioma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Meningioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Grape includes active ingredients Vitamin E, Pterostilbene, Resveratrol and others. And Persimmon contains active ingredients Quercetin, Betulinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Meningioma, activation or inhibition of selected biochemical pathways like mRNA Splicing, DNA Repair, Oncogenic Cancer Epigenetics, Suppressive Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Meningioma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MENINGIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Meningioma undergoing chemotherapy treatment
In Meningioma – the genes DNMT3A, TET2, NF2, TERT and ASXL1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Meningioma are mRNA Splicing, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers mRNA Splicing, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Soy Bean or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Soy Bean are Quercetin, Ferulic Acid, Vitamin E, Daidzein, Genistein among others. While the active ingredients contained in Lima Bean are Genistein and others.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways DNA Repair.
Genistein can manipulate biochemical pathways DNA Repair. And so on.
When treating Meningioma with chemotherapy Radiation – Foods like Soy Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Ferulic Acid contained in Soy Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SOY BEAN IS RECOMMENDED OVER LIMA BEAN FOR MENINGIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Olive?
Vegetables are an important part of many diets. The active ingredients contained in Olive are Quercetin, Betulinic Acid, Ferulic Acid among others.
Quercetin can manipulate biochemical pathways DNA Repair. Betulinic Acid has biological action on biochemical pathways Hedgehog Signaling.
When treating Meningioma with chemotherapy Radiation – Foods like Olive are recommended. This is because the active ingredients Quercetin and Betulinic Acid contained in Olive support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: OLIVE IS RECOMMENDED FOR MENINGIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Grape?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Betulinic Acid among others. While the active ingredients contained in Grape are Vitamin E, Pterostilbene, Resveratrol and others.
Quercetin can manipulate biochemical pathways DNA Repair. Betulinic Acid has biological action on biochemical pathways Hedgehog Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pterostilbene has biological action on biochemical pathways DNA Repair. And so on.
When treating Meningioma with chemotherapy Radiation – Foods like Persimmon are recommended compared to Grape. This is because the active ingredients Resveratrol and Pterostilbene in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Betulinic Acid contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER GRAPE FOR MENINGIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Walnut?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Betulinic Acid, Vitamin E, Gallic Acid, Juglone among others.
Quercetin can manipulate biochemical pathways DNA Repair. Betulinic Acid has biological action on biochemical pathways Hedgehog Signaling.
When treating Meningioma with chemotherapy Radiation – Foods like Walnut are recommended. This is because the active ingredients Quercetin and Betulinic Acid contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED FOR MENINGIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Meningioma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NF2 and ASXL1 are two genes whose abnormalities are risk factors for Meningioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Meningioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Meningioma gene NF2 has causative impact on biological pathways like Hippo Signaling, Cytoskeletal Dynamics and Growth Factor Signaling. And ASXL1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NF2 and ASXL1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NF2 and ASXL1 should be avoided.
Eat more pulses, Mung Bean or Chickpea?
The active ingredients contained in Mung Bean are Vitamin C, Oleic Acid, Quercetin, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Suppressive Histone Methylation, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.
For genetic risk of Meningioma due to abnormalities in genes NF2 and ASXL1 – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF MENINGIOMA DUE TO GENES NF2 AND ASXL1
Eat more vegetables, Giant Butterbur or Chicory?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Meningioma due to abnormalities in genes NF2 and ASXL1 – Foods like Giant Butterbur are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF MENINGIOMA DUE TO GENES NF2 AND ASXL1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Star Fruit or Huckleberry?
The active ingredients contained in Star Fruit are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, Quercetin, Ferulic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Meningioma due to abnormalities in genes NF2 and ASXL1 – Foods like Star Fruit are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF MENINGIOMA DUE TO GENES NF2 AND ASXL1
Eat more nuts, Pistachio or Cashew Nut?
The active ingredients contained in Pistachio are Resveratrol, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Gallic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways mRNA Splicing, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Meningioma due to abnormalities in genes NF2 and ASXL1 – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF MENINGIOMA DUE TO GENES NF2 AND ASXL1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Meningioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.