Foods for Malignant Peripheral Nerve Sheath Tumor!

Introduction

Foods for Malignant Peripheral Nerve Sheath Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare type of cancer that develops in the protective lining of the nerves. Detailed pathology outlines are essential for its diagnosis, often involving cytology to identify its characteristics. Patients with MPNST may experience symptoms related to nerve compression, and radiology plays a critical role in the tumor’s detection and staging. The survival rate of MPNST varies, particularly in advanced stages like stage 4, where the prognosis is generally poorer. Treatment typically includes surgery, chemotherapy, and radiation therapy, with the approach tailored based on the tumor’s location, size, and staging. The ICD-10 coding system categorizes MPNST for healthcare documentation and research purposes. NF1 (Neurofibromatosis Type 1) is a known risk factor for developing MPNST, and the condition is also observed in dogs. Understanding the nature of MPNST, including its orthobullets profile – a reference for orthopedic conditions – is crucial for effective management and improving outcomes for patients affected by this challenging cancer.

For Malignant Peripheral Nerve Sheath Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Malignant Peripheral Nerve Sheath Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Malignant Peripheral Nerve Sheath Tumor?

For example does it matter if vegetable Carrot is consumed more compared to Swamp Cabbage? Does it make any difference if fruit Pummelo is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Adzuki Bean over Cowpea. And if what I eat matters – then how does one identify foods which are recommended for Malignant Peripheral Nerve Sheath Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Malignant Peripheral Nerve Sheath Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Isoliquiritigenin, Catechol, Lupeol, Lycopene. And Rabbiteye Blueberry contains active ingredients Quercetin, Linalool, Gallic Acid, Eugenol, Geraniol and possibly others.

A common mistake made when deciding and choosing foods to eat for Malignant Peripheral Nerve Sheath Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Malignant Peripheral Nerve Sheath Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Malignant Peripheral Nerve Sheath Tumor?

Personalized nutrition for cancers like Malignant Peripheral Nerve Sheath Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Malignant Peripheral Nerve Sheath Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Malignant Peripheral Nerve Sheath Tumor

All cancers like Malignant Peripheral Nerve Sheath Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Malignant Peripheral Nerve Sheath Tumor. Biochemical pathways like Inositol Phosphate Signaling, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle are part of the signature definition of Malignant Peripheral Nerve Sheath Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Malignant Peripheral Nerve Sheath Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Malignant Peripheral Nerve Sheath Tumor when taking cancer treatment Trametinib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

NF1, TP53, SUZ12, TERT and ATM are the top ranked reported genes for Malignant Peripheral Nerve Sheath Tumor. NF1 is reported in 12.3 % of the representative patients across all clinical trials. And TP53 is reported in 9.6 %. The combined population patient data cover ages from 20 to 68. 55.6 % of the patient data are identified as men. The Malignant Peripheral Nerve Sheath Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Malignant Peripheral Nerve Sheath Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CARROT or SWAMP CABBAGE?

Vegetable Carrot contains many active ingredients or bioactives such as Quercetin, Isoliquiritigenin, Vitamin D3, Linalool, Catechol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Carrot is recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib. This is because Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Isoliquiritigenin, Catechol, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, WNT Beta Catenin Signaling and Amino Acid Metabolism and others. Swamp Cabbage is not recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CARROT IS RECOMMENDED OVER SWAMP CABBAGE FOR Malignant Peripheral Nerve Sheath Tumor AND TREATMENT Trametinib.

Choose Fruit RABBITEYE BLUEBERRY or PUMMELO?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Linalool, Gallic Acid, Eugenol, Geraniol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Rabbiteye Blueberry is recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Isoliquiritigenin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and WNT Beta Catenin Signaling and others. Pummelo is not recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER PUMMELO FOR Malignant Peripheral Nerve Sheath Tumor AND TREATMENT Trametinib.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Myricetin, Isoliquiritigenin, Catechol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Myricetin, Isoliquiritigenin, Catechol. These active ingredients manipulate various biochemical pathways like DNA Repair and WNT Beta Catenin Signaling and others. European Chestnut is not recommended for Malignant Peripheral Nerve Sheath Tumor when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Malignant Peripheral Nerve Sheath Tumor AND TREATMENT Trametinib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Malignant Peripheral Nerve Sheath Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHINESE BROCCOLI?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Chinese Broccoli is not recommended when risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE BROCCOLI FOR ATM GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Formononetin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Grapefruit is not recommended when risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR ATM GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, RAS-RAF Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Malignant Peripheral Nerve Sheath Tumor when associated genetic risk is ATM because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR ATM GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Malignant Peripheral Nerve Sheath Tumor. Malignant Peripheral Nerve Sheath Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Malignant Peripheral Nerve Sheath Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Malignant Peripheral Nerve Sheath Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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