Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Malignant Peripheral Nerve Sheath Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Malignant Peripheral Nerve Sheath Tumor because of SUZ12 and ATM gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Malignant Peripheral Nerve Sheath Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Guggul and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MALIGNANT PERIPHERAL NERVE SHEATH TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Malignant Peripheral Nerve Sheath Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Malignant Peripheral Nerve Sheath Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Malignant Peripheral Nerve Sheath Tumor from cBioPortal. The patients enrolled in the studies for Malignant Peripheral Nerve Sheath Tumor are in ages between 20 to 68 with an average age of 42. 55.6% of males and 44.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 97; the top genes with mutations and other abnormalities for Malignant Peripheral Nerve Sheath Tumor include genes NF1, TP53, SUZ12, TERT and ATM. The occurrence frequency distribution for these genes respectively is 12.3%, 9.6%, 8.2%, 5.5% and 4.1%. These tumor genetic details of Malignant Peripheral Nerve Sheath Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Malignant Peripheral Nerve Sheath Tumor.
Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare and aggressive type of sarcoma that originates from the cells that form the sheath that covers and protects peripheral nerves. This can grow in the soft tissues of the body, such as muscle, fat, tendons, ligaments, lymph and blood vessels, nerves and other tissues that connects and supports the body. MPNST grows quickly and can spread to other parts of the body. It can occur in individuals with Neurofibromatosis type 1 (NF1) and is also seen in patients without any underlying genetic predisposition. MPSNT is most common in young and middle-aged adults. Initially some people with MPSNT may not have any symptoms, but as the tumor gets larger, they can have symptoms of pain, weakness, a growing lump under the skin. The diagnosis of MPNST is made through a combination of MRI, IHC, and biopsy, and the management of MPNST may include surgical resection, radiation therapy, and chemotherapy. The recurrence rate of MPNST is high, making close follow-up and surveillance important for proper management and optimal outcomes. Additionally, supportive care with optimal nutrition (food and natural supplements) can help improve the well-being of patients with MPSNT. (Ref: https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-soft-tissue-tumors/mpnst; https://www.mayoclinic.org/diseases-conditions/malignant-peripheral-nerve-sheath-tumors/symptoms-causes/syc-20362603; Cao Y et al, Front. Oncol., 2022,)
Significance of Nutrition for Malignant Peripheral Nerve Sheath Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Malignant Peripheral Nerve Sheath Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Resveratrol, Vitamin C, Caffeic Acid, P-coumaric Acid and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Hesperidin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Malignant Peripheral Nerve Sheath Tumor, activation or inhibition of selected biochemical pathways like Inositol Phosphate Signaling, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Malignant Peripheral Nerve Sheath Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Malignant Peripheral Nerve Sheath Tumor undergoing chemotherapy treatment
In Malignant Peripheral Nerve Sheath Tumor – the genes NF1, TP53, SUZ12, TERT and ATM have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Malignant Peripheral Nerve Sheath Tumor are Inositol Phosphate Signaling, RAS-RAF Signaling, Amino Acid Metabolism and others. Trametinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Inositol Phosphate Signaling, RAS-RAF Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Hyacinth Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Liquiritigenin among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Myristic Acid, Genistein, Palmitic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Adherens junction and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Vitamin D Signaling and MAPK Signaling.
Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, Growth Factor Signaling and MAPK Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.
When treating Malignant Peripheral Nerve Sheath Tumor with chemotherapy Trametinib – Foods like Scarlet Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.
Eat more vegetables, Parsnip or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Parsnip are Quercetin, Vitamin C, Oleic Acid, Psoralen, Gallic Acid among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Kaempferol, Oleic Acid, Vitamin A and others.
Bergapten can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Imperatorin has biological action on biochemical pathways DNA Repair, Vitamin D Signaling and MAPK Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Malignant Peripheral Nerve Sheath Tumor with chemotherapy Trametinib – Foods like Parsnip are recommended compared to Endive. This is because the active ingredients Linolenic Acid and Folic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Bergapten and Imperatorin contained in Parsnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARSNIP IS RECOMMENDED OVER ENDIVE FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.
Eat more fruits, Orange or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Hesperidin, Vitamin C among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Caffeic Acid, P-coumaric Acid and others.
D-limonene can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and Vitamin D Signaling. Vitamin C has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and MAPK Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Delphinidin has biological action on biochemical pathways DNA Repair. And so on.
When treating Malignant Peripheral Nerve Sheath Tumor with chemotherapy Trametinib – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Delphinidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Vitamin A, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Myristic Acid, Palmitic Acid, Lauric Acid, Folic Acid and others.
Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, Adherens junction and DNA Repair. Vitamin E has biological action on biochemical pathways Notch Signaling, MYC Signaling and Vitamin D Signaling.
Myristic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and RAS-RAF Signaling. Palmitic Acid has biological action on biochemical pathways WNT Beta Catenin Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Malignant Peripheral Nerve Sheath Tumor with chemotherapy Trametinib – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid and Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR MALIGNANT PERIPHERAL NERVE SHEATH TUMOR ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Malignant Peripheral Nerve Sheath Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SUZ12 and ATM are two genes whose abnormalities are risk factors for Malignant Peripheral Nerve Sheath Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Malignant Peripheral Nerve Sheath Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Malignant Peripheral Nerve Sheath Tumor gene SUZ12 has causative impact on biological pathways like Suppressive Histone Methylation, Inositol Phosphate Signaling and Post Translation Modification. And ATM has a causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SUZ12 and ATM should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SUZ12 and ATM should be avoided.
Eat more pulses, Lentils or Chickpea?
The active ingredients contained in Lentils are Esculin, Vitamin C, Daidzein, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.
Esculin can manipulate biochemical pathways MYC Signaling, DNA Repair and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Malignant Peripheral Nerve Sheath Tumor due to abnormalities in genes SUZ12 and ATM – Foods like Lentils are recommended compared to Chickpea. This is because the active ingredients Genistein and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Esculin and Vitamin C contained in Lentils together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: LENTILS IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOR DUE TO GENES SUZ12 AND ATM
Eat more vegetables, Jicama or Chicory?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Beta-carotene, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Protocatechuic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Betulinic Acid can manipulate biochemical pathways DNA Repair. Salicylic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Malignant Peripheral Nerve Sheath Tumor due to abnormalities in genes SUZ12 and ATM – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Betulinic Acid and Salicylic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOR DUE TO GENES SUZ12 AND ATM
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Hyperoside, P-coumaric Acid, Ellagic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics, RAS-RAF Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Malignant Peripheral Nerve Sheath Tumor due to abnormalities in genes SUZ12 and ATM – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOR DUE TO GENES SUZ12 AND ATM
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Malignant Peripheral Nerve Sheath Tumor due to abnormalities in genes SUZ12 and ATM – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOR DUE TO GENES SUZ12 AND ATM
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Malignant Peripheral Nerve Sheath Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Sarc Tcga Pan Can Atlas 2018
- Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
- Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
- Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
- An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
- Oncogenic Signaling Pathways in The Cancer Genome Atlas.
- Microbiome analyses of blood and tissues suggest cancer diagnostic approach.
- Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
- Landscape of Microsatellite Instability Across 39 Cancer Types.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
- Sequence homology of surface membrane proteins of Babesia rodhaini.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
- Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway.
- Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge.
- Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.