Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Fibromatosis when undergoing chemotherapy or when you determine you have a genetic risk for developing Fibromatosis because of CTNNB1 and KDR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Fibromatosis which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lichee” or “Include fruit Black Chokeberry in my diet” or “Should I reduce consumption of vegetable Squash” or “Can I take Neem Extract and Tangerine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FIBROMATOSIS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Fibromatosis is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR FIBROMATOSIS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Fibromatosis
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Fibromatosis from cBioPortal. 38.5% of males and 61.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 13; the top genes with mutations and other abnormalities for Fibromatosis include genes CTNNB1, KDR and JAK1. The occurrence frequency distribution for these genes respectively is 75.0%, 8.3% and 8.3%. These tumor genetic details of Fibromatosis are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Fibromatosis.
Fibromatosis, also called desmoid tumors, are rare, benign (noncancerous) growths that occur in the connective tissue, most often in the abdomen, arms and legs. These fibromatosis desmoid tumors do not spread to other areas of the body, but their growth can be very aggressive, and they can grow into nearby organs and structures. Symptoms of fibromatosis desmoid tumors differ based on where the tumor occur, and they can form anywhere in the body. The general symptoms may include a mass or swelling, pain, loss of function in the affected area and cramping and nausea when the desmoid tumor is in the abdomen. These fibromatosis desmoid tumors most often occur in younger adults, and rarely in children and older individuals, and tend to be more common in females. Treatment modalities for fibromatosis desmoid tumors include surgery, radiation therapy, and as a last option, chemotherapy, only for those tumors that have a rapid growth and for which surgery is not an option. Fibromatosis desmoid tumors have a good prognosis and a 5-year survival of more than 98%, but survival rates may vary depending on the size and location of the tumor and response to the treatment. Supportive care with the right nutrition (foods and supplements) can help enhance the well-being of the patient. (Ref: https://my.clevelandclinic.org/health/diseases/22075-desmoid-tumors; https://www.mayoclinic.org/diseases-conditions/desmoid-tumors/symptoms-causes/syc-20355083)
Significance of Nutrition for Fibromatosis
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Fibromatosis. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lichee includes active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Folic Acid, Oleic Acid and others. And Black Chokeberry contains active ingredients Quercetin, Isorhamnetin, Caffeic Acid, Isoquercitrin, Hyperoside and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Fibromatosis, activation or inhibition of selected biochemical pathways like Angiogenesis, JAK-STAT Signaling, Adherens junction, Epithelial to Mesenchymal Transition plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Fibromatosis, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FIBROMATOSIS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Fibromatosis undergoing chemotherapy treatment
In Fibromatosis – the genes CTNNB1, KDR and JAK1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Fibromatosis are Angiogenesis, JAK-STAT Signaling, Epithelial to Mesenchymal Transition and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, JAK-STAT Signaling, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Hyacinth Bean?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Folic Acid, Palmitic Acid and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Isoliquiritigenin has biological action on biochemical pathways JAK-STAT Signaling, Angiogenesis and Epithelial to Mesenchymal Transition.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling. And so on.
When treating Fibromatosis with chemotherapy Radiation – Foods like Adzuki Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR FIBROMATOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Squash?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Chlorogenic Acid, Protocatechuic Acid, Vitamin C, Beta-carotene among others. While the active ingredients contained in Squash are Ellagic Acid, Beta-sitosterol, Vitamin E, Vitamin A, Vitamin C and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, JAK-STAT Signaling and Angiogenesis. Chlorogenic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, JAK-STAT Signaling and Angiogenesis.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling. And so on.
When treating Fibromatosis with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Squash. This is because the active ingredients Ellagic Acid and Folic Acid in Squash interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Chlorogenic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER SQUASH FOR FIBROMATOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Black Chokeberry or Lichee?
Fruits are an important part of many diets. The active ingredients contained in Black Chokeberry are Quercetin, Isorhamnetin, Caffeic Acid, Isoquercitrin, Hyperoside among others. While the active ingredients contained in Lichee are Beta-sitosterol, Vitamin C, Linolenic Acid, Folic Acid, Oleic Acid and others.
Caffeic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Angiogenesis and Epithelial to Mesenchymal Transition.
Folic Acid can manipulate biochemical pathways JAK-STAT Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Fibromatosis with chemotherapy Radiation – Foods like Black Chokeberry are recommended compared to Lichee. This is because the active ingredients Folic Acid and Oleic Acid in Lichee interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Caffeic Acid and Quercetin contained in Black Chokeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK CHOKEBERRY IS RECOMMENDED OVER LICHEE FOR FIBROMATOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Acorn or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin A, Vitamin C, Beta-carotene among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Folic Acid, Lecithin, Oleic Acid and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, JAK-STAT Signaling and Angiogenesis. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Angiogenesis.
Lecithin can manipulate biochemical pathways JAK-STAT Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling. And so on.
When treating Fibromatosis with chemotherapy Radiation – Foods like Acorn are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-sitosterol contained in Acorn support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ACORN IS RECOMMENDED OVER BRAZIL NUT FOR FIBROMATOSIS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Fibromatosis
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and KDR are two genes whose abnormalities are risk factors for Fibromatosis. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Fibromatosis can be used as a guide for coming up with a recommended personalized nutrition plan. For Fibromatosis gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And KDR has a causative impact on biological pathways like Angiogenesis and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and KDR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and KDR should be avoided.
Eat more pulses, Common Pea or Pigeon Pea?
The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Delphinidin among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Genistein and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Fibromatosis due to abnormalities in genes CTNNB1 and KDR – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF FIBROMATOSIS DUE TO GENES CTNNB1 AND KDR
Eat more vegetables, Cassava or Endive?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Fibromatosis due to abnormalities in genes CTNNB1 and KDR – Foods like Cassava are recommended compared to Endive. This is because the active ingredients Oleic Acid and Linoleic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF FIBROMATOSIS DUE TO GENES CTNNB1 AND KDR
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Bilberry or Malus (crab Apple)?
The active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, Delphinidin, Caffeic Acid among others. While the active ingredients contained in Malus (crab Apple) are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.
Delphinidin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Angiogenesis. Chlorogenic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Fibromatosis due to abnormalities in genes CTNNB1 and KDR – Foods like Bilberry are recommended compared to Malus (crab Apple). This is because the active ingredients Oleic Acid and Linoleic Acid in Malus (crab Apple) further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Chlorogenic Acid contained in Bilberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR REDUCING THE GENETIC RISK OF FIBROMATOSIS DUE TO GENES CTNNB1 AND KDR
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Gamma-linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Fibromatosis due to abnormalities in genes CTNNB1 and KDR – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Oleic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF FIBROMATOSIS DUE TO GENES CTNNB1 AND KDR
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Fibromatosis by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition.
- Targeting metastasis-initiating cells through the fatty acid receptor CD36.
- Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- Research progress on the anticancer effects of vitamin K2.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.