Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Esophagogastric Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Esophagogastric Adenocarcinoma because of CDKN2A and SMAD4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Esophagogastric Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Squashberry in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Dim and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ESOPHAGOGASTRIC ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Esophagogastric Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ESOPHAGOGASTRIC ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Esophagogastric Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Esophagogastric Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Esophagogastric Adenocarcinoma are in ages between 23 to 89 with an average age of 61. 75.2% of males and 24.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 1267; the top genes with mutations and other abnormalities for Esophagogastric Adenocarcinoma include genes DNMT3A, PPM1D, CDKN2A, SMAD4 and TET2. The occurrence frequency distribution for these genes respectively is 11.0%, 3.2%, 3.0%, 2.5% and 2.5%. These tumor genetic details of Esophagogastric Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Esophagogastric Adenocarcinoma.
Significance of Nutrition for Esophagogastric Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Esophagogastric Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Quercetin, Caffeic Acid, Resveratrol, Vitamin C, Hyperoside and others. And Squashberry contains active ingredients Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Esophagogastric Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Esophagogastric Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ESOPHAGOGASTRIC ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Esophagogastric Adenocarcinoma undergoing chemotherapy treatment
In Esophagogastric Adenocarcinoma – the genes DNMT3A, PPM1D, CDKN2A, SMAD4 and TET2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Esophagogastric Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Delphinidin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Genistein, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. And so on.
When treating Esophagogastric Adenocarcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ESOPHAGOGASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Giant Butterbur or Cauliflower?
Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Melatonin, Vitamin A, Vitamin B3 among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Brassinin, Indole-3-carbinol, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.
Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Esophagogastric Adenocarcinoma with chemotherapy Radiation – Foods like Giant Butterbur are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAULIFLOWER FOR ESOPHAGOGASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Squashberry or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Squashberry are Vitamin C, Vitamin A among others. While the active ingredients contained in Lingonberry are Quercetin, Caffeic Acid, Resveratrol, Vitamin C, Hyperoside and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and TGFB Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Esophagogastric Adenocarcinoma with chemotherapy Radiation – Foods like Squashberry are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Caffeic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin C contained in Squashberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SQUASHBERRY IS RECOMMENDED OVER LINGONBERRY FOR ESOPHAGOGASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Esophagogastric Adenocarcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Vitamin E in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR ESOPHAGOGASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Esophagogastric Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDKN2A and SMAD4 are two genes whose abnormalities are risk factors for Esophagogastric Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Esophagogastric Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Esophagogastric Adenocarcinoma gene CDKN2A has causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. And SMAD4 has a causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDKN2A and SMAD4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDKN2A and SMAD4 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Quercetin, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Esophagogastric Adenocarcinoma due to abnormalities in genes CDKN2A and SMAD4 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ESOPHAGOGASTRIC ADENOCARCINOMA DUE TO GENES CDKN2A AND SMAD4
Eat more vegetables, Arugula or Carob?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Gallic Acid, Phloroglucinol and others.
Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and Cell Cycle. Vitamin A has biological action on biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Esophagogastric Adenocarcinoma due to abnormalities in genes CDKN2A and SMAD4 – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF ESOPHAGOGASTRIC ADENOCARCINOMA DUE TO GENES CDKN2A AND SMAD4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Raspberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Vitamin C, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Esophagogastric Adenocarcinoma due to abnormalities in genes CDKN2A and SMAD4 – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF ESOPHAGOGASTRIC ADENOCARCINOMA DUE TO GENES CDKN2A AND SMAD4
Eat more nuts, Pecan Nut or Chestnut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Linolenic Acid, Vitamin C, Oleic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Esophagogastric Adenocarcinoma due to abnormalities in genes CDKN2A and SMAD4 – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ESOPHAGOGASTRIC ADENOCARCINOMA DUE TO GENES CDKN2A AND SMAD4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Esophagogastric Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Access 2021
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Small-molecule inhibitors of NADPH oxidase 4.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Inhibitory effect of brassinin on TNF‑α‑induced vascular inflammation in human umbilical vein endothelial cells.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.