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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia?

Aug 21, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Early T Cell Precursor Acute Lymphoblastic Leukemia because of NOTCH1 and JAK1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Early T Cell Precursor Acute Lymphoblastic Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Quince” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Kaempferol and Elecampane supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Early T Cell Precursor Acute Lymphoblastic Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Early T Cell Precursor Acute Lymphoblastic Leukemia

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Early T Cell Precursor Acute Lymphoblastic Leukemia from cBioPortal. The patients enrolled in the studies for Early T Cell Precursor Acute Lymphoblastic Leukemia are in ages between 3 to 20 with an average age of 15. 83.3% of males and 16.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 6; the top genes with mutations and other abnormalities for Early T Cell Precursor Acute Lymphoblastic Leukemia include genes NOTCH1, JAK1, CDK12, MMP24 and TCF7L2. The occurrence frequency distribution for these genes respectively is 83.3%, 50.0%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Early T Cell Precursor Acute Lymphoblastic Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Early T Cell Precursor Acute Lymphoblastic Leukemia.

Significance of Nutrition for Early T Cell Precursor Acute Lymphoblastic Leukemia

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Early T Cell Precursor Acute Lymphoblastic Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Quince includes active ingredients Modified Citrus Pectin, Chlorogenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others. And Mulberry contains active ingredients Morusin, Resveratrol, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia, activation or inhibition of selected biochemical pathways like Apoptosis, RAS-RAF Signaling, JAK-STAT Signaling, Notch Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Early T Cell Precursor Acute Lymphoblastic Leukemia, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

Foods to avoid for Lung Carcinoid with chemotherapy treatment and Foods recommended for genetic risk of Lung Carcinoid due to gene abnormalities of EIF1AX AND MEN1 genes abnormalities.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Early T Cell Precursor Acute Lymphoblastic Leukemia undergoing chemotherapy treatment

In Early T Cell Precursor Acute Lymphoblastic Leukemia – the genes NOTCH1, JAK1, CDK12, MMP24 and TCF7L2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Early T Cell Precursor Acute Lymphoblastic Leukemia are Apoptosis, RAS-RAF Signaling, MAPK Signaling and others. Nelarabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, RAS-RAF Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Adzuki Bean or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Oleic Acid, Stigmasterol, Beta-sitosterol, Linoleic Acid and others.

Glucaric Acid can manipulate biochemical pathways Apoptosis, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Isoliquiritigenin has biological action on biochemical pathways MAPK Signaling, JAK-STAT Signaling and RAS-RAF Signaling.

Beta-sitosterol can manipulate biochemical pathways Apoptosis and Oncogenic Cancer Epigenetics. Stigmasterol has biological action on biochemical pathways Apoptosis. And so on.

When treating Early T Cell Precursor Acute Lymphoblastic Leukemia with chemotherapy Nelarabine – Foods like Adzuki Bean are recommended compared to Moth Bean. This is because the active ingredients Beta-sitosterol and Stigmasterol in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER MOTH BEAN FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY NELARABINE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Okra?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Vitamin K, Erysolin, Esculin, Vitamin A among others. While the active ingredients contained in Okra are Quercetin, Salicylic Acid, Linolenic Acid, Oleic Acid, Beta-sitosterol and others.

Kaempferol can manipulate biochemical pathways MAPK Signaling, JAK-STAT Signaling and RAS-RAF Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Apoptosis. Quercetin has biological action on biochemical pathways Noncoding RNA Signaling, Suppressive Histone Methylation and Oncogenic Cancer Epigenetics. And so on.

When treating Early T Cell Precursor Acute Lymphoblastic Leukemia with chemotherapy Nelarabine – Foods like Arugula are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER OKRA FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY NELARABINE FOR SOME CONDITIONS.

Which Foods are Recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia?

Eat more fruits, Mulberry or Quince?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Morusin, Resveratrol, Deoxynojirimycin among others. While the active ingredients contained in Quince are Modified Citrus Pectin, Chlorogenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.

Morusin can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and JAK-STAT Signaling. Resveratrol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and RAS-RAF Signaling.

Quercitrin can manipulate biochemical pathways Apoptosis. Modified Citrus Pectin has biological action on biochemical pathways Apoptosis. And so on.

When treating Early T Cell Precursor Acute Lymphoblastic Leukemia with chemotherapy Nelarabine – Foods like Mulberry are recommended compared to Quince. This is because the active ingredients Quercitrin and Modified Citrus Pectin in Quince interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Resveratrol contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER QUINCE FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY NELARABINE FOR SOME CONDITIONS.

Eat more nuts, Almond or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Salicylic Acid, Linolenic Acid, Geraniin, Vitamin E among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Myristic Acid, Lauric Acid, Palmitic Acid, Folic Acid and others.

Salicylic Acid can manipulate biochemical pathways MAPK Signaling, JAK-STAT Signaling and RAS-RAF Signaling. Geraniin has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and JAK-STAT Signaling.

Beta-sitosterol can manipulate biochemical pathways Apoptosis and Oncogenic Cancer Epigenetics. Myristic Acid has biological action on biochemical pathways MAPK Signaling and RAS-RAF Signaling. And so on.

When treating Early T Cell Precursor Acute Lymphoblastic Leukemia with chemotherapy Nelarabine – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Beta-sitosterol and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Salicylic Acid and Geraniin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY NELARABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Early T Cell Precursor Acute Lymphoblastic Leukemia

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and JAK1 are two genes whose abnormalities are risk factors for Early T Cell Precursor Acute Lymphoblastic Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Early T Cell Precursor Acute Lymphoblastic Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Early T Cell Precursor Acute Lymphoblastic Leukemia gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And JAK1 has a causative impact on biological pathways like Hematopoiesis, Interferon Signaling and IL10 Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and JAK1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and JAK1 should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Stigmasterol, Quercetin, Linolenic Acid, Oleic Acid, Vitexin among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Genistein and others.

Vitexin can manipulate biochemical pathways MYC Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MYC Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and Apoptosis. And so on.

For genetic risk of Early T Cell Precursor Acute Lymphoblastic Leukemia due to abnormalities in genes NOTCH1 and JAK1 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitexin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NOTCH1 AND JAK1

Eat more vegetables, Milk Thistle or Japanese Pumpkin?

The active ingredients contained in Milk Thistle are Silibinin, Vitamin E, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Japanese Pumpkin are Vitamin E, Palmitic Acid, Beta-sitosterol, Vitamin C, Vitamin A and others.

Silibinin can manipulate biochemical pathways JAK-STAT Signaling, IL27 Signaling and RUNX Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, Apoptosis and Notch Signaling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Early T Cell Precursor Acute Lymphoblastic Leukemia due to abnormalities in genes NOTCH1 and JAK1 – Foods like Milk Thistle are recommended compared to Japanese Pumpkin. This is because the active ingredients Palmitic Acid and Lauric Acid in Japanese Pumpkin further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER JAPANESE PUMPKIN FOR REDUCING THE GENETIC RISK OF EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NOTCH1 AND JAK1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Roselle or Strawberry?

The active ingredients contained in Roselle are Stigmasterol, Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Strawberry are Lupeol, Salicylic Acid, Linolenic Acid, Beta-sitosterol, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways RUNX Signaling, MYC Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MYC Signaling and Apoptosis.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Early T Cell Precursor Acute Lymphoblastic Leukemia due to abnormalities in genes NOTCH1 and JAK1 – Foods like Roselle are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin C contained in Roselle together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ROSELLE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NOTCH1 AND JAK1

Eat more nuts, Walnut or Chestnut?

The active ingredients contained in Walnut are Stigmasterol, Myricetin, Vitamin E, D-limonene, Protocatechuic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Ellagic Acid and others.

Myricetin can manipulate biochemical pathways JAK-STAT Signaling, IL27 Signaling and MYC Signaling. D-limonene has biological action on biochemical pathways Apoptosis and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, Apoptosis and MYC Signaling. And so on.

For genetic risk of Early T Cell Precursor Acute Lymphoblastic Leukemia due to abnormalities in genes NOTCH1 and JAK1 – Foods like Walnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Myricetin and D-limonene contained in Walnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NOTCH1 AND JAK1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Early T Cell Precursor Acute Lymphoblastic Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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