Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Duodenal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Duodenal Adenocarcinoma because of CTNNB1 and KRAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Duodenal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DUODENAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Duodenal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DUODENAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Duodenal Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Duodenal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Duodenal Adenocarcinoma are in ages between 34 to 90 with an average age of 60. 64.5% of males and 35.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 121; the top genes with mutations and other abnormalities for Duodenal Adenocarcinoma include genes KRAS, TP53, DNMT3A, KMT2D and CTNNB1. The occurrence frequency distribution for these genes respectively is 26.7%, 22.2%, 13.3%, 11.1% and 11.1%. These tumor genetic details of Duodenal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Duodenal Adenocarcinoma.
Adenocarcinoma duodenal is a type of cancer that affects the duodenum, the first part of the small intestine. Duodenal adenocarcinoma affects the cells that produce the chemicals and enzymes that help with the digestion of the food. Duodenal adenocarcinoma is often diagnosed in later stages due to the lack of symptoms in the early stages. As the tumor grows, it may block proper digestion and cause symptoms of nausea, abdominal pain, or constipation. Most duodenal adenocarcinomas affect older adults in the age group of 60-80 years of age. Conditions such as celiac disease or Crohn’s disease can increase the risk of duodenal adenocarcinoma, in addition to life-style habits such as smoking, alcohol and eating a high-salt diet. The staging of duodenal adenocarcinoma is crucial for determining the appropriate treatment plan and prognosis. Stage 4 duodenal adenocarcinoma is considered the most advanced stage and often results in the cancer having spread to distant parts of the body. Effective management of duodenal adenocarcinoma requires a multi-disciplinary approach, including surgery, chemotherapy, and radiation therapy, along with careful monitoring and follow-up. Outlook for duodenal adenocarcinoma is better when detected in early stages. Optimal nutrition (foods and natural supplements) along with the treatment and monitoring can help improve the patient’s well-being. (Ref: https://my.clevelandclinic.org/health/diseases/22735-duodenal-cancer; https://www.medicalnewstoday.com/articles/324309#survival-rates; Sun H et al, Front. Oncol., 2021,)
Significance of Nutrition for Duodenal Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Duodenal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Peach includes active ingredients Beta-sitosterol, Modified Citrus Pectin, Oleic Acid, Linolenic Acid, Vitamin C and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Duodenal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, RUNX Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Duodenal Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DUODENAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Duodenal Adenocarcinoma undergoing chemotherapy treatment
In Duodenal Adenocarcinoma – the genes KRAS, TP53, DNMT3A, KMT2D and CTNNB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Duodenal Adenocarcinoma are Cell Cycle, RUNX Signaling, Notch Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, RUNX Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Oleic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Oxidative Stress. Esculin has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Duodenal Adenocarcinoma with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR DUODENAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Yam?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Beta-carotene, Vitamin C, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Yam are Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C, Dioscin and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Duodenal Adenocarcinoma with chemotherapy Cisplatin – Foods like Jicama are recommended compared to Yam. This is because the active ingredients Citric Acid and Oleic Acid in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER YAM FOR DUODENAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Nance or Peach?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Peach are Beta-sitosterol, Modified Citrus Pectin, Oleic Acid, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Betulin has biological action on biochemical pathways Cell Survival, MYC Signaling and MAPK Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Modified Citrus Pectin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Duodenal Adenocarcinoma with chemotherapy Cisplatin – Foods like Nance are recommended compared to Peach. This is because the active ingredients Citric Acid and Modified Citrus Pectin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER PEACH FOR DUODENAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways Inositol Phosphate Signaling, DNA Repair and Cell Cycle.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and NFKB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Duodenal Adenocarcinoma with chemotherapy Cisplatin – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR DUODENAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Duodenal Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and KRAS are two genes whose abnormalities are risk factors for Duodenal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Duodenal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Duodenal Adenocarcinoma gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And KRAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and Immune Evasion Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and KRAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and KRAS should be avoided.
Eat more pulses, Scarlet Bean or Chickpea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Vitamin A, Genistein, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and Cell Cycle Checkpoints.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Duodenal Adenocarcinoma due to abnormalities in genes CTNNB1 and KRAS – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Oleic Acid and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF DUODENAL ADENOCARCINOMA DUE TO GENES CTNNB1 AND KRAS
Eat more vegetables, Arugula or Endive?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Kaempferol and others.
Kaempferol can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Duodenal Adenocarcinoma due to abnormalities in genes CTNNB1 and KRAS – Foods like Arugula are recommended compared to Endive. This is because the active ingredients Oleic Acid and Linoleic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF DUODENAL ADENOCARCINOMA DUE TO GENES CTNNB1 AND KRAS
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Raspberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Vitamin A, Chlorogenic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Vitamin C, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
For genetic risk of Duodenal Adenocarcinoma due to abnormalities in genes CTNNB1 and KRAS – Foods like Kiwi are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Rutin in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF DUODENAL ADENOCARCINOMA DUE TO GENES CTNNB1 AND KRAS
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Duodenal Adenocarcinoma due to abnormalities in genes CTNNB1 and KRAS – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF DUODENAL ADENOCARCINOMA DUE TO GENES CTNNB1 AND KRAS
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Duodenal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Met 2021
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis.
- Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells.
- Synergistic Antioxidant and Anti-Inflammatory Effects between Modified Citrus Pectin and Honokiol.
- β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
- Clinical pharmacodynamics of antihistamines.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Research progress on the anticancer effects of vitamin K2.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.