Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Clear Cell Ovarian Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Clear Cell Ovarian Cancer because of PPM1D and CHEK2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Clear Cell Ovarian Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Mango” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Birch and Silymarin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CLEAR CELL OVARIAN CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Clear Cell Ovarian Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CLEAR CELL OVARIAN CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Clear Cell Ovarian Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Clear Cell Ovarian Cancer from cBioPortal. The patients enrolled in the studies for Clear Cell Ovarian Cancer are in ages between 14 to 91 with an average age of 61.From a patient sample size of 797; the top genes with mutations and other abnormalities for Clear Cell Ovarian Cancer include genes DNMT3A, PPM1D, CHEK2, ASXL1 and PIK3CA. The occurrence frequency distribution for these genes respectively is 32.2%, 24.5%, 7.7%, 1.5% and 1.5%. These tumor genetic details of Clear Cell Ovarian Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Clear Cell Ovarian Cancer.
Significance of Nutrition for Clear Cell Ovarian Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Clear Cell Ovarian Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Mango includes active ingredients Lupeol, Beta-sitosterol, Linoleic Acid, Oleic Acid, Vitamin C and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Clear Cell Ovarian Cancer, activation or inhibition of selected biochemical pathways like C-type Lectin Receptor Signaling, RUNX Signaling, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Clear Cell Ovarian Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CLEAR CELL OVARIAN CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Clear Cell Ovarian Cancer undergoing chemotherapy treatment
In Clear Cell Ovarian Cancer – the genes DNMT3A, PPM1D, CHEK2, ASXL1 and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Clear Cell Ovarian Cancer are C-type Lectin Receptor Signaling, RUNX Signaling, Notch Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers C-type Lectin Receptor Signaling, RUNX Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Yellow Wax Bean are Ferulic Acid, Vitamin C, Cianidanol, Butyric Acid, Palmitic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, P53 Signaling and MAPK Signaling.
Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling and MAPK Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Clear Cell Ovarian Cancer with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Vitamin A in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR CLEAR CELL OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Indole-3-carbinol, Isorhamnetin among others. While the active ingredients contained in Spinach are Apigenin, Quercetin, Beta-sitosterol, Linoleic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Glucaric Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Apigenin can manipulate biochemical pathways DNA Repair and Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Clear Cell Ovarian Cancer with chemotherapy Carboplatin – Foods like Cabbage are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SPINACH FOR CLEAR CELL OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Feijoa or Mango?
Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Mango are Lupeol, Beta-sitosterol, Linoleic Acid, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways JAK-STAT Signaling, WNT Beta Catenin Signaling and P53 Signaling.
Gallic Acid can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Clear Cell Ovarian Cancer with chemotherapy Carboplatin – Foods like Feijoa are recommended compared to Mango. This is because the active ingredients Gallic Acid and Vitamin A in Mango interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER MANGO FOR CLEAR CELL OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linoleic Acid, Oleic Acid, Linolenic Acid, Cianidanol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, DNA Repair and Cell Cycle. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and RUNX Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and MAPK Signaling. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Clear Cell Ovarian Cancer with chemotherapy Carboplatin – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Linolenic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR CLEAR CELL OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Clear Cell Ovarian Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPM1D and CHEK2 are two genes whose abnormalities are risk factors for Clear Cell Ovarian Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Clear Cell Ovarian Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Clear Cell Ovarian Cancer gene PPM1D has causative impact on biological pathways like DNA Repair. And CHEK2 has a causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPM1D and CHEK2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPM1D and CHEK2 should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Linolenic Acid, Beta-sitosterol, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.
Pelargonidin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Clear Cell Ovarian Cancer due to abnormalities in genes PPM1D and CHEK2 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF CLEAR CELL OVARIAN CANCER DUE TO GENES PPM1D AND CHEK2
Eat more vegetables, Cassava or Celery?
The active ingredients contained in Cassava are Vitamin C, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Linolenic Acid, Quercetin, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics and MAPK Signaling. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Clear Cell Ovarian Cancer due to abnormalities in genes PPM1D and CHEK2 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF CLEAR CELL OVARIAN CANCER DUE TO GENES PPM1D AND CHEK2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Star Fruit or Raspberry?
The active ingredients contained in Star Fruit are Vitamin C, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Resveratrol, Quercetin, Ellagic Acid, Rutin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Clear Cell Ovarian Cancer due to abnormalities in genes PPM1D and CHEK2 – Foods like Star Fruit are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF CLEAR CELL OVARIAN CANCER DUE TO GENES PPM1D AND CHEK2
Eat more nuts, Almond or Chestnut?
The active ingredients contained in Almond are Vitamin E, Linolenic Acid, Beta-sitosterol, Stigmasterol, Quercetin among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Ellagic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Clear Cell Ovarian Cancer due to abnormalities in genes PPM1D and CHEK2 – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF CLEAR CELL OVARIAN CANCER DUE TO GENES PPM1D AND CHEK2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Clear Cell Ovarian Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Ch 2020
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- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Small-molecule inhibitors of NADPH oxidase 4.
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- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.