Foods for Clear Cell Ovarian Cancer!

Introduction

Foods for Clear Cell Ovarian Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Clear Cell Ovarian Cancer, a subtype of ovarian cancer clear cell carcinoma, is known for its distinct pathology and challenging prognosis. Women diagnosed with this cancer often experience symptoms like abdominal pain and bloating. The survival rate varies depending on the stage, with stage 3 clear cell ovarian cancer generally having a more guarded prognosis compared to stage 1a. Treatment typically involves surgery and chemotherapy, and there’s an ongoing focus on clinical trials to explore more effective therapeutic options. Recurrence symptoms are a major concern, emphasizing the importance of regular follow-ups and adjuvant chemotherapy in some cases. Survivor stories provide insights into the personal experiences of clear cell ovarian cancer survivors, highlighting the importance of support and awareness. Ultrasound is a key diagnostic tool, while research into the genetics of clear cell ovarian cancer aims to improve understanding and treatment. Understanding the early symptoms of clear cell ovarian cancer is crucial for timely diagnosis and effective management, potentially improving outcomes for those affected by this challenging disease.

For Clear Cell Ovarian Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Clear Cell Ovarian Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Clear Cell Ovarian Cancer?

For example does it matter if vegetable Cauliflower is consumed more compared to Broccoli? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Cowpea over Green Bean. And if what I eat matters – then how does one identify foods which are recommended for Clear Cell Ovarian Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Clear Cell Ovarian Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Catechol, Curcumin, Delphinidin, Apigenin. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Catechol, Curcumin, Delphinidin and possibly others.

A common mistake made when deciding and choosing foods to eat for Clear Cell Ovarian Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Clear Cell Ovarian Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Clear Cell Ovarian Cancer?

Personalized nutrition for cancers like Clear Cell Ovarian Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Clear Cell Ovarian Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Clear Cell Ovarian Cancer

All cancers like Clear Cell Ovarian Cancer can be characterized by a unique set of biochemical pathways – the signature pathways. Biochemical pathways like Angiogenesis, Extracellular Matrix Remodelling, Oncogenic Cancer Epigenetics, DNA Repair are part of the signature definition of Clear Cell Ovarian Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Clear Cell Ovarian Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Clear Cell Ovarian Cancer when taking cancer treatment Bevacizumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, PPM1D, CHEK2, ASXL1 and PIK3CA are the top ranked reported genes for Clear Cell Ovarian Cancer. DNMT3A is reported in 32.2 % of the representative patients across all clinical trials. And PPM1D is reported in 24.5 %. The combined population patient data cover ages from 14 to 91. 0.0 % of the patient data are identified as men. The Clear Cell Ovarian Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Clear Cell Ovarian Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or BROCCOLI?

Vegetable Cauliflower contains many active ingredients or bioactives such as Catechol, Curcumin, Delphinidin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling and Chemokine Signaling and others. Cauliflower is recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bevacizumab.

Some of the active ingredients or bioactives in vegetable Broccoli are Quercetin, Resveratrol, Catechol, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Broccoli is not recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER BROCCOLI FOR Clear Cell Ovarian Cancer AND TREATMENT Bevacizumab.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Catechol, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Angiogenesis, PI3K-AKT-MTOR Signaling and Hypoxia and others. Red Raspberry is recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bevacizumab.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Catechol, Curcumin, Delphinidin, Apigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Clear Cell Ovarian Cancer AND TREATMENT Bevacizumab.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Catechol, Curcumin, Delphinidin, Apigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, EPHRIN Signaling, PI3K-AKT-MTOR Signaling and Chemokine Signaling and others. Butternut is recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bevacizumab.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Catechol, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Clear Cell Ovarian Cancer when ongoing cancer treatment is Bevacizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Clear Cell Ovarian Cancer AND TREATMENT Bevacizumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Clear Cell Ovarian Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Catechol, Curcumin, Apigenin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Insulin Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Quercetin, Catechol, Curcumin, Apigenin, Myricetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Insulin Signaling and Oncogenic Cancer Epigenetics and others. Malabar Spinach is not recommended when risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Catechol, Curcumin, Apigenin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Catechol, Curcumin, Lupeol, Beta-sitosterol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and DAP12 Signaling and others. Grapefruit is not recommended when risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or JAPANESE CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Quercetin, Catechol, Curcumin, Myricetin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Chestnut are Catechol, Curcumin, Apigenin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair, Insulin Signaling and Oncogenic Cancer Epigenetics and others. Japanese Chestnut is not recommended when risk of Clear Cell Ovarian Cancer when associated genetic risk is ASXL1 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER JAPANESE CHESTNUT FOR ASXL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Clear Cell Ovarian Cancer. Clear Cell Ovarian Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Clear Cell Ovarian Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Clear Cell Ovarian Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Ch 2020
• Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats.