Which Foods are Recommended for Paget Disease Of The Breast?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Paget Disease Of The Breast when undergoing chemotherapy or when you determine you have a genetic risk for developing Paget Disease Of The Breast because of APOB and MTR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Paget Disease Of The Breast which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Quince” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Mulberry and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PAGET DISEASE OF THE BREAST, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Paget Disease Of The Breast is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PAGET DISEASE OF THE BREAST, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Paget Disease Of The Breast

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Paget Disease Of The Breast from cBioPortal. The top genes with mutations and other abnormalities for Paget Disease Of The Breast include genes KMT2C, APOB, MTR, BRWD1 and ARID2. The occurrence frequency distribution for these genes respectively is 34.0%, 24.0%, 20.0%, 20.0% and 17.0%. These tumor genetic details of Paget Disease Of The Breast are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Paget Disease Of The Breast.

Paget’s disease of the breast is a rare cancer, accounting for only 1-3% cases of female breast cancer. It mainly affects post-menopausal women, and occurrence in men is an extremely rare finding. It is a malignant disease that presents itself as eroding and bleeding ulcer of the nipple, starting with eczema-like changes including itching, scaling, and crusting, and discharge. Paget’s disease represents an extension of a ductal breast adenocarcinoma. The 5-year recurrence free survial of paget’s disease of the breast is 75-90% with ductal carcinoma in situ (DCIS) and 63-75% with invasive carcinoma. Treatment of Paget’s disease involves surgery followed by adjuvant therapy that may include radiation therapy, chemotherapy, or hormone therapy, appropriately supported by right nutrition (foods and natural supplements) aligned to the treatment context. (Ref: Ooi PS et al, Korean J Fam Med., 2019; https://rarediseases.org/rare-diseases/pagets-disease-of-the-breast/)

Significance of Nutrition for Paget Disease Of The Breast

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Paget Disease Of The Breast. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Quince includes active ingredients Vitamin C, Oleic Acid, Quercitrin, Chlorogenic Acid, Modified Citrus Pectin and others. And Mulberry contains active ingredients Resveratrol, Morusin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Paget Disease Of The Breast, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Paget Disease Of The Breast, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PAGET DISEASE OF THE BREAST – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Paget Disease Of The Breast undergoing chemotherapy treatment

In Paget Disease Of The Breast – the genes KMT2C, APOB, MTR, BRWD1 and ARID2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Paget Disease Of The Breast are Cell Cycle Checkpoints, Growth Factor Signaling, PI3K-AKT-MTOR Signaling and others. Letrozole is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Growth Factor Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Vitamin C, Beta-sitosterol, Quercetin, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

When treating Paget Disease Of The Breast with chemotherapy Letrozole – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR PAGET DISEASE OF THE BREAST ON TREATMENT WITH CHEMOTHERAPY LETROZOLE FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Vitamin C, Beta-sitosterol, Quercetin, Brassinin among others. While the active ingredients contained in Spinach are Apigenin, Vitamin C, Beta-sitosterol, Quercetin, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and Cell Cycle Checkpoints. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Apigenin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Paget Disease Of The Breast with chemotherapy Letrozole – Foods like Cabbage are recommended compared to Spinach. This is because the active ingredients Apigenin and Linoleic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SPINACH FOR PAGET DISEASE OF THE BREAST ON TREATMENT WITH CHEMOTHERAPY LETROZOLE FOR SOME CONDITIONS.

Eat more fruits, Mulberry or Quince?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin among others. While the active ingredients contained in Quince are Vitamin C, Oleic Acid, Quercitrin, Chlorogenic Acid, Modified Citrus Pectin and others.

Morusin can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Growth Factor Signaling.

Quercitrin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Paget Disease Of The Breast with chemotherapy Letrozole – Foods like Mulberry are recommended compared to Quince. This is because the active ingredients Quercitrin and Linoleic Acid in Quince interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Resveratrol contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER QUINCE FOR PAGET DISEASE OF THE BREAST ON TREATMENT WITH CHEMOTHERAPY LETROZOLE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Delphinidin, Cianidanol among others. While the active ingredients contained in Acorn are Vitamin C, Beta-sitosterol, Quercetin, Beta-carotene, Quercitrin and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and Cell Cycle Checkpoints. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Growth Factor Signaling.

Quercitrin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Paget Disease Of The Breast with chemotherapy Letrozole – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercitrin and Vitamin B3 in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR PAGET DISEASE OF THE BREAST ON TREATMENT WITH CHEMOTHERAPY LETROZOLE FOR SOME CONDITIONS.

Foods for Genetic Risk of Paget Disease Of The Breast

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. APOB and MTR are two genes whose abnormalities are risk factors for Paget Disease Of The Breast. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Paget Disease Of The Breast can be used as a guide for coming up with a recommended personalized nutrition plan. For Paget Disease Of The Breast gene APOB has causative impact on biological pathways like Focal Adhesion and NFKB Signaling. And MTR has a causative impact on biological pathways like Folate Signaling and Amino Acid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like APOB and MTR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes APOB and MTR should be avoided.

Eat more pulses, Common Bean or Soy Bean?

The active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin E, Daidzein, Ferulic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling. Esculin has biological action on biochemical pathways MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling. Quercetin has biological action on biochemical pathways Complement Cascade. And so on.

For genetic risk of Paget Disease Of The Breast due to abnormalities in genes APOB and MTR – Foods like Common Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Quercetin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Esculin contained in Common Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PAGET DISEASE OF THE BREAST DUE TO GENES APOB AND MTR

Eat more vegetables, Artichoke or Jute?

The active ingredients contained in Artichoke are Apigenin, Vitamin C, Chlorogenic Acid, Naringenin, Cynaroside among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Oleic Acid, Vitamin B3, Linolenic Acid and others.

Vitamin K can manipulate biochemical pathways MYC Signaling and Calcium Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling.

Quercetin can manipulate biochemical pathways Complement Cascade. Linolenic Acid has biological action on biochemical pathways Complement Cascade. And so on.

For genetic risk of Paget Disease Of The Breast due to abnormalities in genes APOB and MTR – Foods like Artichoke are recommended compared to Jute. This is because the active ingredients Quercetin and Linolenic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Vitamin C contained in Artichoke together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF PAGET DISEASE OF THE BREAST DUE TO GENES APOB AND MTR

Eat more fruits, Pummelo or Cherry?

The active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Vitamin C, Chlorogenic Acid, Naringenin among others. While the active ingredients contained in Cherry are Quercetin, Beta-sitosterol, Vitamin C, Chlorogenic Acid, Oleic Acid and others.

Naringin can manipulate biochemical pathways MYC Signaling and Post Translation Modification. Naringenin has biological action on biochemical pathways Extracellular Matrix Remodelling and MYC Signaling.

Quercetin can manipulate biochemical pathways Complement Cascade. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport and Calcium Signaling. And so on.

For genetic risk of Paget Disease Of The Breast due to abnormalities in genes APOB and MTR – Foods like Pummelo are recommended compared to Cherry. This is because the active ingredients Quercetin and Isorhamnetin in Cherry further promote the effects of genes on the biochemical pathways. While the active ingredients Naringin and Naringenin contained in Pummelo together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PUMMELO IS RECOMMENDED OVER CHERRY FOR REDUCING THE GENETIC RISK OF PAGET DISEASE OF THE BREAST DUE TO GENES APOB AND MTR

Eat more nuts, Chestnut or Almond?

The active ingredients contained in Chestnut are Gallic Acid, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Stigmasterol and others.

Gallic Acid can manipulate biochemical pathways MYC Signaling, Calcium Signaling and Notch Signaling. Ellagic Acid has biological action on biochemical pathways Post Translation Modification and Notch Signaling.

Quercetin can manipulate biochemical pathways Complement Cascade. Linolenic Acid has biological action on biochemical pathways Complement Cascade. And so on.

For genetic risk of Paget Disease Of The Breast due to abnormalities in genes APOB and MTR – Foods like Chestnut are recommended compared to Almond. This is because the active ingredients Quercetin and Linolenic Acid in Almond further promote the effects of genes on the biochemical pathways. While the active ingredients Gallic Acid and Ellagic Acid contained in Chestnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER ALMOND FOR REDUCING THE GENETIC RISK OF PAGET DISEASE OF THE BREAST DUE TO GENES APOB AND MTR

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Paget Disease Of The Breast by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Induction of apoptosis by morusin in human non-small cell lung cancer cells by suppression of EGFR/STAT3 activation.
• Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
• Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells.
• Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
• Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Thrombin inhibitory activity of some polyphenolic compounds.
• NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.
• Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways.
• Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.
• Research progress on the anticancer effects of vitamin K2.
• Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
• Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways.
• Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.