Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hypopharyngeal Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Hypopharyngeal Cancer because of PAX5 and PTEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Hypopharyngeal Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Sea Buckthorn” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Hesperidin and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HYPOPHARYNGEAL CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Hypopharyngeal Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HYPOPHARYNGEAL CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Hypopharyngeal Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Hypopharyngeal Cancer from cBioPortal. The patients enrolled in the studies for Hypopharyngeal Cancer are in ages between 52 to 74 with an average age of 60. 77.3% of males and 22.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Hypopharyngeal Cancer include genes TP53, KMT2D, PAX5, PTEN and PIK3CA. The occurrence frequency distribution for these genes respectively is 44.4%, 22.2%, 11.1%, 11.1% and 11.1%. These tumor genetic details of Hypopharyngeal Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hypopharyngeal Cancer.
Significance of Nutrition for Hypopharyngeal Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hypopharyngeal Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Sea Buckthorn includes active ingredients Beta-sitosterol, Isorhamnetin, Oleic Acid, Vitamin C, Linolenic Acid and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Hypopharyngeal Cancer, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hypopharyngeal Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HYPOPHARYNGEAL CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Hypopharyngeal Cancer undergoing chemotherapy treatment
In Hypopharyngeal Cancer – the genes TP53, KMT2D, PAX5, PTEN and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hypopharyngeal Cancer are Growth Factor Signaling, Extracellular Matrix Remodelling, Inositol Phosphate Signaling and others. Imatinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, Extracellular Matrix Remodelling, Inositol Phosphate Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Chickpea?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Vitamin C, Glucaric Acid, Linolenic Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, Oxidative Stress and Extracellular Matrix Remodelling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle.
Vitamin A can manipulate biochemical pathways Oxidative Stress and Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hypopharyngeal Cancer with chemotherapy Imatinib – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Oleic Acid in Chickpea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR HYPOPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Oleic Acid, Sulforaphane, Vitamin C, Brassinin among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle. Brassinin has biological action on biochemical pathways Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Vitamin A can manipulate biochemical pathways Oxidative Stress and Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hypopharyngeal Cancer with chemotherapy Imatinib – Foods like Kohlrabi are recommended compared to Endive. This is because the active ingredients Vitamin A and Oleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER ENDIVE FOR HYPOPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Sea Buckthorn?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P among others. While the active ingredients contained in Sea Buckthorn are Beta-sitosterol, Isorhamnetin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Morusin can manipulate biochemical pathways Inositol Phosphate Signaling, Extracellular Matrix Remodelling and Cell Cycle. Resveratrol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Inositol Phosphate Signaling.
Beta-sitosterol can manipulate biochemical pathways Oxidative Stress. Isorhamnetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hypopharyngeal Cancer with chemotherapy Imatinib – Foods like Mulberry are recommended compared to Sea Buckthorn. This is because the active ingredients Beta-sitosterol and Isorhamnetin in Sea Buckthorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Resveratrol contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER SEA BUCKTHORN FOR HYPOPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Oleic Acid, Gallic Acid, Vitamin C and others.
Vitamin K can manipulate biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways Inositol Phosphate Signaling, Oxidative Stress and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Oxidative Stress. Betulin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Hypopharyngeal Cancer with chemotherapy Imatinib – Foods like Pine Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Betulin in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin K and Vitamin E contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CHESTNUT FOR HYPOPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Hypopharyngeal Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PAX5 and PTEN are two genes whose abnormalities are risk factors for Hypopharyngeal Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hypopharyngeal Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Hypopharyngeal Cancer gene PAX5 has causative impact on biological pathways like TGFB Signaling, RUNX Signaling and Suppressive Histone Methylation. And PTEN has a causative impact on biological pathways like Autophagy and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PAX5 and PTEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PAX5 and PTEN should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Caffeic Acid, Vitamin E, Daidzein and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lupeol has biological action on biochemical pathways Inositol Phosphate Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.
For genetic risk of Hypopharyngeal Cancer due to abnormalities in genes PAX5 and PTEN – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lupeol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF HYPOPHARYNGEAL CANCER DUE TO GENES PAX5 AND PTEN
Eat more vegetables, Jicama or Radish?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Caffeic Acid, Beta-sitosterol, Isorhamnetin, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Hypopharyngeal Cancer due to abnormalities in genes PAX5 and PTEN – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF HYPOPHARYNGEAL CANCER DUE TO GENES PAX5 AND PTEN
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Strawberry?
The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Hesperidin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Cianidanol, Oleic Acid and others.
D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.
For genetic risk of Hypopharyngeal Cancer due to abnormalities in genes PAX5 and PTEN – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF HYPOPHARYNGEAL CANCER DUE TO GENES PAX5 AND PTEN
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.
Vitamin E can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Vanillic Acid has biological action on biochemical pathways MAPK Signaling. And so on.
For genetic risk of Hypopharyngeal Cancer due to abnormalities in genes PAX5 and PTEN – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vanillic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF HYPOPHARYNGEAL CANCER DUE TO GENES PAX5 AND PTEN
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Hypopharyngeal Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.