Foods for Chondroblastic Osteosarcoma!

Introduction

Foods for Chondroblastic Osteosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Chondroblastic osteosarcoma, a subtype of osteosarcoma cancer characterized by the production of cartilaginous matrix, presents unique challenges in diagnosis and treatment. The pathology outlines and histology of chondroblastic osteosarcoma reveal its distinct features, including chondroid and osteoid elements, which are key to differentiating it from chondrosarcoma. Radiology, particularly MRI and CT scans, plays a crucial role in the assessment of the tumor, providing detailed images of its size and extent. This cancer, covered under the ICD-10 classification, can affect both humans and animals, with cases noted in dogs. Symptoms typically include pain and swelling at the tumor site, which can occur in various bones, including the jaw and maxilla. The survival rate and prognosis for chondroblastic osteosarcoma vary, depending on factors such as the tumor’s location, size, and response to treatment. Treatment generally involves a combination of surgery and chemotherapy, aimed at removing the tumor and reducing the risk of metastasis. Understanding the causes of chondroblastic osteosarcoma, although still under research, is crucial for developing preventive strategies. The management of this aggressive cancer requires a multidisciplinary approach, focusing on both surgical removal of the tumor and systemic treatment to improve the chances of a favorable outcome for patients affected by this challenging condition.

For Chondroblastic Osteosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Chondroblastic Osteosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Chondroblastic Osteosarcoma?

For example does it matter if vegetable Wild Leek is consumed more compared to Romaine Lettuce? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over European Chestnut and for pulses like Hyacinth Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Chondroblastic Osteosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Chondroblastic Osteosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Quercetin, Caffeine, Lupeol, Formononetin. And Red Raspberry contains active ingredients Ellagic Acid, Curcumin, Quercetin, Lupeol, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Chondroblastic Osteosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Chondroblastic Osteosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Chondroblastic Osteosarcoma?

Personalized nutrition for cancers like Chondroblastic Osteosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Chondroblastic Osteosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Chondroblastic Osteosarcoma

All cancers like Chondroblastic Osteosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Chondroblastic Osteosarcoma. Biochemical pathways like Cell Cycle, Angiogenesis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics are part of the signature definition of Chondroblastic Osteosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Chondroblastic Osteosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Chondroblastic Osteosarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TERT, IDH1, IDH2, BCOR and ERBB3 are the top ranked reported genes for Chondroblastic Osteosarcoma. TERT is reported in 29.4 % of the representative patients across all clinical trials. And IDH1 is reported in 17.6 %. The combined population patient data cover ages from to . 57.7 % of the patient data are identified as men. The Chondroblastic Osteosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Chondroblastic Osteosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable WILD LEEK or ROMAINE LETTUCE?

Vegetable Wild Leek contains many active ingredients or bioactives such as Curcumin, Lupeol, Formononetin, Phloretin, Apigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Cell Cycle, Epithelial to Mesenchymal Transition and TGFB Signaling and others. Wild Leek is recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation. This is because Wild Leek modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Romaine Lettuce are Curcumin, Lupeol, Phloretin, Formononetin, Apigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, TGFB Signaling and DNA Repair and others. Romaine Lettuce is not recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE WILD LEEK IS RECOMMENDED OVER ROMAINE LETTUCE FOR Chondroblastic Osteosarcoma AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Epithelial to Mesenchymal Transition, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Quercetin, Caffeine, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Pummelo is not recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Chondroblastic Osteosarcoma AND TREATMENT Radiation.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Caffeine, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, JAK-STAT Signaling and Epithelial to Mesenchymal Transition and others. Common Hazelnut is recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and TGFB Signaling and others. European Chestnut is not recommended for Chondroblastic Osteosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Chondroblastic Osteosarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Chondroblastic Osteosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GARDEN RHUBARB?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garden Rhubarb are Curcumin, Apigenin, Quercetin, Emodin, Rhein. These active ingredients manipulate various biochemical pathways like Glutathione Metabolism and others. Garden Rhubarb is not recommended when risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARDEN RHUBARB FOR BCOR GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Delphinidin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Formononetin, Lycopene, Lupeol, Delphinidin. These active ingredients manipulate various biochemical pathways like Glutathione Metabolism and others. Grapefruit is not recommended when risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR BCOR GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or PILI NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Apoptosis and others. Butternut is recommended for risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pili Nut are Curcumin, Apigenin, Formononetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Glutathione Metabolism and Oncogenic Cancer Epigenetics and others. Pili Nut is not recommended when risk of Chondroblastic Osteosarcoma when associated genetic risk is BCOR because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER PILI NUT FOR BCOR GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Chondroblastic Osteosarcoma. Chondroblastic Osteosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Chondroblastic Osteosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Wild Leek contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Chondroblastic Osteosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Anti-Metastatic Effects of Lupeol via the Inhibition of MAPK/ERK Pathway in Lung Cancer.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.