Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Burkitt Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Burkitt Lymphoma because of MYC and ID3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Burkitt Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Artemisinine and Vitamin D3 supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BURKITT LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Burkitt Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BURKITT LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Burkitt Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Burkitt Lymphoma from cBioPortal. The patients enrolled in the studies for Burkitt Lymphoma are in ages between 4 to 18 with an average age of 10. 94.1% of males and 5.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 125; the top genes with mutations and other abnormalities for Burkitt Lymphoma include genes MYC, ID3, TP53, CCND3 and SMARCA4. The occurrence frequency distribution for these genes respectively is 41.1%, 31.5%, 27.4%, 25.8% and 21.0%. These tumor genetic details of Burkitt Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Burkitt Lymphoma.
Burkitt lymphoma is an aggressive non-Hodgkin B-cell lymphoma, a blood cancer that affects the lymphocytes, the immune cells that help the body fight infection. It is a rare cancer. It is classified as endemic, related to malaria and Epstein Barr virus (EBV), a sporadic form, and an immunodeficiency-related form that is associated with human immunodeficiency virus (HIV) and could also be due to organ transplantation. Burkitt lymphoma is more common in Caucasians and more prevalent in males with a 3-4:1 male to female ratio. Burkitt lymphoma is also more commonly diagnosed in children and less frequently in young adults. Symptoms of Burkitt lymphoma include abdominal (belly) pain, nausea and vomiting, loss of appetite, weakness and fatigue, swollen lymph nodes and could also cause unintended weight loss. Burkitt lymphomas are treated aggressively with combination chemotherapy regimens. Additionally, the right supportive nutrition (foods and natural supplements) along with the treatment can help better deal with the side-effects of the intensive treatments and improve patients’ well-being. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK538148/ ; https://my.clevelandclinic.org/health/diseases/22777-burkitt-lymphoma ; https://lymphoma-action.org.uk/types-lymphoma-non-hodgkin-lymphoma/burkitt-lymphoma )
Significance of Nutrition for Burkitt Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Burkitt Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Resveratrol, Hyperoside, Ellagic Acid, Quercetin, Vitamin C and others. And Mulberry contains active ingredients Resveratrol, Morusin, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Burkitt Lymphoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Chemokine Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Burkitt Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BURKITT LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Burkitt Lymphoma undergoing chemotherapy treatment
In Burkitt Lymphoma – the genes MYC, ID3, TP53, CCND3 and SMARCA4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Burkitt Lymphoma are MAPK Signaling, Chemokine Signaling, Amino Acid Metabolism and others. Vincristine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Chemokine Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, Vitamin D Signaling and MAPK Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Linoleic Acid has biological action on biochemical pathways Chemokine Signaling. And so on.
When treating Burkitt Lymphoma with chemotherapy Vincristine – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR BURKITT LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more vegetables, Broccoli or Cauliflower?
Vegetables are an important part of many diets. The active ingredients contained in Broccoli are Brassinin, Sulforaphane, Vitamin C, Indole-3-carbinol, Oleic Acid among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Brassinin, Sulforaphane, Vitamin C, Indole-3-carbinol and others.
Brassinin can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Sulforaphane has biological action on biochemical pathways DNA Repair, Cell Cycle and MYC Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Linoleic Acid has biological action on biochemical pathways Chemokine Signaling. And so on.
When treating Burkitt Lymphoma with chemotherapy Vincristine – Foods like Broccoli are recommended compared to Cauliflower. This is because the active ingredients Linolenic Acid and Linoleic Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Sulforaphane contained in Broccoli support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BROCCOLI IS RECOMMENDED OVER CAULIFLOWER FOR BURKITT LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin among others. While the active ingredients contained in Cranberry are Resveratrol, Hyperoside, Ellagic Acid, Quercetin, Vitamin C and others.
Morusin can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Deoxynojirimycin has biological action on biochemical pathways Cell Survival and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Vitamin D Signaling. Myricetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Burkitt Lymphoma with chemotherapy Vincristine – Foods like Mulberry are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER CRANBERRY FOR BURKITT LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A, Cianidanol among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Salicylic Acid, Stigmasterol and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle, MYC Signaling and Vitamin D Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Lecithin has biological action on biochemical pathways NFKB Signaling, Chemokine Signaling and MYC Signaling. And so on.
When treating Burkitt Lymphoma with chemotherapy Vincristine – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR BURKITT LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Burkitt Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYC and ID3 are two genes whose abnormalities are risk factors for Burkitt Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Burkitt Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Burkitt Lymphoma gene MYC has causative impact on biological pathways like Noncoding RNA Signaling and MAPK Signaling. And ID3 has a causative impact on biological pathways like TGFB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYC and ID3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYC and ID3 should be avoided.
Eat more pulses, Yellow Wax Bean or Common Bean?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Palmitic Acid, Vitamin A, Ferulic Acid, Butyric Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, P-coumaric Acid, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Vitamin A has biological action on biochemical pathways Vitamin D Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Apigenin can manipulate biochemical pathways Vitamin D Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
For genetic risk of Burkitt Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Yellow Wax Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Gamma-linolenic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF BURKITT LYMPHOMA DUE TO GENES MYC AND ID3
Eat more vegetables, Mexican Groundcherry or Bell Pepper?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, P-coumaric Acid, Capsaicin, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Burkitt Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Mexican Groundcherry are recommended compared to Bell Pepper. This is because the active ingredients Linolenic Acid and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF BURKITT LYMPHOMA DUE TO GENES MYC AND ID3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Raspberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Resveratrol, Salicylic Acid, Vitamin A, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Vitamin D Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
For genetic risk of Burkitt Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Gallic Acid in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF BURKITT LYMPHOMA DUE TO GENES MYC AND ID3
Eat more nuts, Hazelnut or Cashew Nut?
The active ingredients contained in Hazelnut are Vitamin E, Linoleic Acid, Linolenic Acid, Vitamin A, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.
For genetic risk of Burkitt Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF BURKITT LYMPHOMA DUE TO GENES MYC AND ID3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Burkitt Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pancan Pcawg 2020
- Pan-cancer analysis of whole genomes.
- Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn’s disease compared with omega-6 fatty acids.
- Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells.
- Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Inhibitory effect of brassinin on TNF‑α‑induced vascular inflammation in human umbilical vein endothelial cells.
- Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
- 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities.
- Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
- Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.