Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like B Cell Acute Lymphoblastic Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing B Cell Acute Lymphoblastic Leukemia because of NRAS and PAX5 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as B Cell Acute Lymphoblastic Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Green Bean” or “Can I take Calcium D-glucarate and Baicalin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO B CELL ACUTE LYMPHOBLASTIC LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for B Cell Acute Lymphoblastic Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About B Cell Acute Lymphoblastic Leukemia
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for B Cell Acute Lymphoblastic Leukemia from cBioPortal. The patients enrolled in the studies for B Cell Acute Lymphoblastic Leukemia are in ages between 1 to 19 with an average age of 15. 46.4% of males and 53.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 63; the top genes with mutations and other abnormalities for B Cell Acute Lymphoblastic Leukemia include genes KRAS, NRAS, PAX5, FLT3 and PIK3CA. The occurrence frequency distribution for these genes respectively is 30.8%, 26.9%, 11.5%, 11.5% and 11.5%. These tumor genetic details of B Cell Acute Lymphoblastic Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of B Cell Acute Lymphoblastic Leukemia.
Significance of Nutrition for B Cell Acute Lymphoblastic Leukemia
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of B Cell Acute Lymphoblastic Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Bilberry includes active ingredients Resveratrol, Myricetin, Quercetin, Asperuloside, P-coumaric Acid and others. And Apple contains active ingredients Modified Citrus Pectin, Glucaric Acid, Phloretin, Rutin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like B Cell Acute Lymphoblastic Leukemia, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of B Cell Acute Lymphoblastic Leukemia, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for B Cell Acute Lymphoblastic Leukemia undergoing chemotherapy treatment
In B Cell Acute Lymphoblastic Leukemia – the genes KRAS, NRAS, PAX5, FLT3 and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for B Cell Acute Lymphoblastic Leukemia are PI3K-AKT-MTOR Signaling and others. Car-t is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid among others. While the active ingredients contained in Fava Bean are Butein, Betulin, Quercetin, Kaempferol, Daidzein and others.
Glucaric Acid can manipulate biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and Macrophage M1. Isoliquiritigenin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Macrophage M2 and Myeloid-derived Suppressor Cells.
Butein can manipulate biochemical pathways Macrophage M1. Quercetin has biological action on biochemical pathways Macrophage M1. And so on.
When treating B Cell Acute Lymphoblastic Leukemia with chemotherapy Car-t – Foods like Adzuki Bean are recommended compared to Fava Bean. This is because the active ingredients Butein and Quercetin in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER FAVA BEAN FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CAR-T FOR SOME CONDITIONS.
Eat more vegetables, Bitter Melon or Green Bean?
Vegetables are an important part of many diets. The active ingredients contained in Bitter Melon are Beta-sitosterol, Cucurbitacin E, P-coumaric Acid, Cucurbitacin I, Caffeic Acid among others. While the active ingredients contained in Green Bean are Kaempferol, Beta-sitosterol, Vitamin C, Oleic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Macrophage M2 and Macrophage M1. Kaempferol has biological action on biochemical pathways Macrophage M1. And so on.
When treating B Cell Acute Lymphoblastic Leukemia with chemotherapy Car-t – Foods like Bitter Melon are recommended compared to Green Bean. This is because the active ingredients Vitamin A and Kaempferol in Green Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Bitter Melon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER GREEN BEAN FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CAR-T FOR SOME CONDITIONS.
Eat more fruits, Apple or Bilberry?
Fruits are an important part of many diets. The active ingredients contained in Apple are Modified Citrus Pectin, Glucaric Acid, Phloretin, Rutin, Chlorogenic Acid among others. While the active ingredients contained in Bilberry are Resveratrol, Myricetin, Quercetin, Asperuloside, P-coumaric Acid and others.
Glucaric Acid can manipulate biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and Macrophage M1. Modified Citrus Pectin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Macrophage M2 and Myeloid-derived Suppressor Cells.
Chlorogenic Acid can manipulate biochemical pathways Macrophage M1. Ursolic Acid has biological action on biochemical pathways Macrophage M1. And so on.
When treating B Cell Acute Lymphoblastic Leukemia with chemotherapy Car-t – Foods like Apple are recommended compared to Bilberry. This is because the active ingredients Chlorogenic Acid and Ursolic Acid in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: APPLE IS RECOMMENDED OVER BILBERRY FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CAR-T FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Oleic Acid, Linoleic Acid, Linolenic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Cucurbitacin I, Salicylic Acid, Gamma-linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Myricitrin has biological action on biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Macrophage M1. Lecithin has biological action on biochemical pathways Macrophage M2, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. And so on.
When treating B Cell Acute Lymphoblastic Leukemia with chemotherapy Car-t – Foods like Hazelnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR B CELL ACUTE LYMPHOBLASTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CAR-T FOR SOME CONDITIONS.
Foods for Genetic Risk of B Cell Acute Lymphoblastic Leukemia
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NRAS and PAX5 are two genes whose abnormalities are risk factors for B Cell Acute Lymphoblastic Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of B Cell Acute Lymphoblastic Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For B Cell Acute Lymphoblastic Leukemia gene NRAS has causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and RAS-RAF Signaling. And PAX5 has a causative impact on biological pathways like TGFB Signaling, RUNX Signaling and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NRAS and PAX5 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NRAS and PAX5 should be avoided.
Eat more pulses, Mung Bean or Moth Bean?
The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Vitexin among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.
For genetic risk of B Cell Acute Lymphoblastic Leukemia due to abnormalities in genes NRAS and PAX5 – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NRAS AND PAX5
Eat more vegetables, Arugula or Radish?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C and others.
Vitamin K can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and P53 Signaling. And so on.
For genetic risk of B Cell Acute Lymphoblastic Leukemia due to abnormalities in genes NRAS and PAX5 – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NRAS AND PAX5
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Huckleberry?
The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Ferulic Acid, P-coumaric Acid and others.
D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of B Cell Acute Lymphoblastic Leukemia due to abnormalities in genes NRAS and PAX5 – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NRAS AND PAX5
Eat more nuts, Almond or Macadamia Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of B Cell Acute Lymphoblastic Leukemia due to abnormalities in genes NRAS and PAX5 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA DUE TO GENES NRAS AND PAX5
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for B Cell Acute Lymphoblastic Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- All Stjude 2015
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- The inhibitory effects of butein on cell proliferation and TNF-α-induced CCL2 release in racially different triple negative breast cancer cells.
- Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells–A SAR study.
- Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development.
- Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway.
- Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
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- Research on Rett syndrome: strategy and preliminary results.
- Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
- Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Research progress on the anticancer effects of vitamin K2.
- Clinical pharmacodynamics of antihistamines.
- Pectin – Wikipedia
- Pectin and Pectin-Based Composite Materials: Beyond Food Texture.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.