Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Pleomorphic Xanthoastrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Pleomorphic Xanthoastrocytoma because of BRAF and NOTCH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Anaplastic Pleomorphic Xanthoastrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Cranberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Mistletoe and Gotu Kola supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Anaplastic Pleomorphic Xanthoastrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Anaplastic Pleomorphic Xanthoastrocytoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Anaplastic Pleomorphic Xanthoastrocytoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 2; the top genes with mutations and other abnormalities for Anaplastic Pleomorphic Xanthoastrocytoma include genes BRAF, NOTCH1, TERT and TP63. The occurrence frequency distribution for these genes respectively is 100.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Anaplastic Pleomorphic Xanthoastrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Pleomorphic Xanthoastrocytoma.
Significance of Nutrition for Anaplastic Pleomorphic Xanthoastrocytoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Pleomorphic Xanthoastrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Coconut includes active ingredients Palmitic Acid, Vitamin E, Beta-sitosterol, Myristic Acid and others. And Cranberry contains active ingredients Ellagic Acid, Chlorogenic Acid, Hyperoside, Myricetin, Quercitrin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Anaplastic Pleomorphic Xanthoastrocytoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Apoptosis, Notch Signaling, RUNX Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Pleomorphic Xanthoastrocytoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Anaplastic Pleomorphic Xanthoastrocytoma undergoing chemotherapy treatment
In Anaplastic Pleomorphic Xanthoastrocytoma – the genes BRAF, NOTCH1, TERT and TP63 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Pleomorphic Xanthoastrocytoma are RAS-RAF Signaling, Apoptosis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Lentils or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Lentils are Ellagic Acid, Oleic Acid, Linolenic Acid, Beta-sitosterol, Daidzein among others. While the active ingredients contained in Common Bean are Oleic Acid, Gamma-linolenic Acid, Linolenic Acid, Apigenin, Esculin and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling and Apoptosis.
Folic Acid can manipulate biochemical pathways Apoptosis. And so on.
When treating Anaplastic Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Lentils are recommended compared to Common Bean. This is because the active ingredients Folic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Beta-sitosterol contained in Lentils support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: LENTILS IS RECOMMENDED OVER COMMON BEAN FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Squash or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Squash are Ellagic Acid, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Spinach are Oleic Acid, Linolenic Acid, Beta-sitosterol, Apigenin, Linoleic Acid and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis and RAS-RAF Signaling. Vitamin E has biological action on biochemical pathways Notch Signaling, RUNX Signaling and Apoptosis.
Folic Acid can manipulate biochemical pathways Apoptosis. And so on.
When treating Anaplastic Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Squash are recommended compared to Spinach. This is because the active ingredients Folic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin E contained in Squash support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SQUASH IS RECOMMENDED OVER SPINACH FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Cranberry or Coconut?
Fruits are an important part of many diets. The active ingredients contained in Cranberry are Ellagic Acid, Chlorogenic Acid, Hyperoside, Myricetin, Quercitrin among others. While the active ingredients contained in Coconut are Palmitic Acid, Vitamin E, Beta-sitosterol, Myristic Acid and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis and RAS-RAF Signaling. Chlorogenic Acid has biological action on biochemical pathways Notch Signaling, RUNX Signaling and Apoptosis.
Myristic Acid can manipulate biochemical pathways Apoptosis, RAS-RAF Signaling and RUNX Signaling. And so on.
When treating Anaplastic Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Cranberry are recommended compared to Coconut. This is because the active ingredients Myristic Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Chlorogenic Acid contained in Cranberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CRANBERRY IS RECOMMENDED OVER COCONUT FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Chestnut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Oleic Acid, Betulin, Gallic Acid, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Folic Acid, Lecithin and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis and RAS-RAF Signaling. Betulin has biological action on biochemical pathways Apoptosis.
Lecithin can manipulate biochemical pathways RAS-RAF Signaling. Folic Acid has biological action on biochemical pathways Apoptosis. And so on.
When treating Anaplastic Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Chestnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Betulin contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER BRAZIL NUT FOR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Anaplastic Pleomorphic Xanthoastrocytoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and NOTCH1 are two genes whose abnormalities are risk factors for Anaplastic Pleomorphic Xanthoastrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Pleomorphic Xanthoastrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Pleomorphic Xanthoastrocytoma gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And NOTCH1 has a causative impact on biological pathways like Notch Signaling and RUNX Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and NOTCH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and NOTCH1 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Vitamin C, Linolenic Acid, Stigmasterol, Vitexin, Oleic Acid among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Vitamin C, Beta-sitosterol, Daidzein and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Stigmasterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and RAS-RAF Signaling. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
For genetic risk of Anaplastic Pleomorphic Xanthoastrocytoma due to abnormalities in genes BRAF and NOTCH1 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Aescin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES BRAF AND NOTCH1
Eat more vegetables, Cassava or Radish?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Radish are Vitamin C, Beta-sitosterol, Linolenic Acid, P-coumaric Acid, Vitamin B3 and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling, MYC Signaling and P53 Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling. And so on.
For genetic risk of Anaplastic Pleomorphic Xanthoastrocytoma due to abnormalities in genes BRAF and NOTCH1 – Foods like Cassava are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES BRAF AND NOTCH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Strawberry?
The active ingredients contained in Orange are D-limonene, Rhamnetin, Linalool, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Vitamin C, Beta-sitosterol, Linolenic Acid and others.
D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Oncogenic Cancer Epigenetics.
Fisetin can manipulate biochemical pathways MYC Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.
For genetic risk of Anaplastic Pleomorphic Xanthoastrocytoma due to abnormalities in genes BRAF and NOTCH1 – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES BRAF AND NOTCH1
Eat more nuts, Almond or Macadamia Nut?
The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin B3 among others. While the active ingredients contained in Macadamia Nut are Palmitic Acid, Beta-sitosterol, Lauric Acid, Folic Acid, Myristic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and P53 Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Anaplastic Pleomorphic Xanthoastrocytoma due to abnormalities in genes BRAF and NOTCH1 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES BRAF AND NOTCH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Anaplastic Pleomorphic Xanthoastrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.