Which Foods are Recommended for Malignant Fibrous Histiocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Malignant Fibrous Histiocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Malignant Fibrous Histiocytoma because of RB1 and TP53 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Malignant Fibrous Histiocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Theaflavin and Naringin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MALIGNANT FIBROUS HISTIOCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Malignant Fibrous Histiocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MALIGNANT FIBROUS HISTIOCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Malignant Fibrous Histiocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Malignant Fibrous Histiocytoma from cBioPortal. The patients enrolled in the studies for Malignant Fibrous Histiocytoma are in ages between 29 to 90 with an average age of 68. 54.0% of males and 46.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 515; the top genes with mutations and other abnormalities for Malignant Fibrous Histiocytoma include genes TP53, ATRX, RB1, TERT and KMT2D. The occurrence frequency distribution for these genes respectively is 14.4%, 4.6%, 3.5%, 3.2% and 2.6%. These tumor genetic details of Malignant Fibrous Histiocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Malignant Fibrous Histiocytoma.

Malignant fibrous histiocytoma (MFH) is also called undifferentiated pleomorphic sarcoma (UPS) or malignant fibrous cytoma, and it is the most common soft tissue sarcoma of late adult life. Malignant fibrous histiocytoma are aggressive tumors that often grow quickly and spread to other parts of the body, including the lung. This is a cancer that originates in the soft tissue that includes muscles, nerves, blood vessels, fats, fibrous tissues (tendons, ligaments, and cartilage), skin, or bone. Malignant fibrous histiocytoma can occur anywhere in the body, but more commonly occurs in the legs (50% of cases in the thighs), arms or back of the abdomen. MFH usually occurs in older adults with a predominance in males and may sometimes occur as a second cancer in patients who had retinoblastoma. Symptoms are usually a painless, enlarging palpable mass while other symptoms may be caused locally depending on the location of the tumor. Malignant fibrous histiocytoma treatment usually includes aggressive resection (surgical removal of the entirety of the tumor). Supplementary adjuvant chemotherapy and radiotherapy are useful in reducing local recurrence rate. Favorable prognostic factors for malignant fibrous histiocytoma include small tumor size, low grade, extremity location, superficial location, and localized disease. In addition, supportive care with the right nutrition (foods and natural supplements) can help improve patients’ well-being. (Ref: https://my.clevelandclinic.org/health/diseases/22435-undifferentiated-pleomorphic-sarcoma; https://healthjade.net/malignant-fibrous-histiocytoma/; https://www.webmd.com/cancer/malignant-fibrous-histiocytoma-of-bone )

Significance of Nutrition for Malignant Fibrous Histiocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Malignant Fibrous Histiocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Fisetin, Beta-sitosterol, Vitamin C, Caffeic Acid, Chlorogenic Acid and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Malignant Fibrous Histiocytoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Malignant Fibrous Histiocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MALIGNANT FIBROUS HISTIOCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Malignant Fibrous Histiocytoma undergoing chemotherapy treatment

In Malignant Fibrous Histiocytoma – the genes TP53, ATRX, RB1, TERT and KMT2D have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Malignant Fibrous Histiocytoma are RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism and others. Everolimus is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Genistein, Lupeol, Daidzein, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Genistein can manipulate biochemical pathways RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Malignant Fibrous Histiocytoma with chemotherapy Everolimus – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR MALIGNANT FIBROUS HISTIOCYTOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Beta-sitosterol, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways Glucocorticoid Signaling, Microtubule Dynamics and Cell Cycle.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling. And so on.

When treating Malignant Fibrous Histiocytoma with chemotherapy Everolimus – Foods like Cassava are recommended compared to Spinach. This is because the active ingredients Apigenin and Glucaric Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SPINACH FOR MALIGNANT FIBROUS HISTIOCYTOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more fruits, Mulberry or Peach?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P, Deoxynojirimycin among others. While the active ingredients contained in Peach are Fisetin, Beta-sitosterol, Vitamin C, Caffeic Acid, Chlorogenic Acid and others.

Morusin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Deoxynojirimycin has biological action on biochemical pathways Cell Survival, Epithelial to Mesenchymal Transition and Growth Factor Signaling.

Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Modified Citrus Pectin has biological action on biochemical pathways RAS-RAF Signaling. And so on.

When treating Malignant Fibrous Histiocytoma with chemotherapy Everolimus – Foods like Mulberry are recommended compared to Peach. This is because the active ingredients Fisetin and Modified Citrus Pectin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER PEACH FOR MALIGNANT FIBROUS HISTIOCYTOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Linolenic Acid, Cianidanol, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Beta-carotene and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and Cell Cycle. Delphinidin has biological action on biochemical pathways Oxidative Stress, MYC Signaling and MAPK Signaling.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.

When treating Malignant Fibrous Histiocytoma with chemotherapy Everolimus – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR MALIGNANT FIBROUS HISTIOCYTOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Foods for Genetic Risk of Malignant Fibrous Histiocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RB1 and TP53 are two genes whose abnormalities are risk factors for Malignant Fibrous Histiocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Malignant Fibrous Histiocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Malignant Fibrous Histiocytoma gene RB1 has causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. And TP53 has a causative impact on biological pathways like Cell Cycle Checkpoints and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RB1 and TP53 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RB1 and TP53 should be avoided.

Eat more pulses, Scarlet Bean or Moth Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Malignant Fibrous Histiocytoma due to abnormalities in genes RB1 and TP53 – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF MALIGNANT FIBROUS HISTIOCYTOMA DUE TO GENES RB1 AND TP53

Eat more vegetables, Giant Butterbur or Kale?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Kale are Indole-3-carbinol, Vitamin C, Linolenic Acid, Brassinin, Sulforaphane and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Malignant Fibrous Histiocytoma due to abnormalities in genes RB1 and TP53 – Foods like Giant Butterbur are recommended compared to Kale. This is because the active ingredients Vitamin A and Linoleic Acid in Kale further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER KALE FOR REDUCING THE GENETIC RISK OF MALIGNANT FIBROUS HISTIOCYTOMA DUE TO GENES RB1 AND TP53

Eat more fruits, Feijoa or Blackberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Blackberry are Ellagic Acid, Quercetin, Hyperoside, Myricetin, Cianidanol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Scopoletin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.

For genetic risk of Malignant Fibrous Histiocytoma due to abnormalities in genes RB1 and TP53 – Foods like Feijoa are recommended compared to Blackberry. This is because the active ingredients Scopoletin and Ellagic Acid in Blackberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER BLACKBERRY FOR REDUCING THE GENETIC RISK OF MALIGNANT FIBROUS HISTIOCYTOMA DUE TO GENES RB1 AND TP53

Eat more nuts, Almond or Chestnut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Malignant Fibrous Histiocytoma due to abnormalities in genes RB1 and TP53 – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF MALIGNANT FIBROUS HISTIOCYTOMA DUE TO GENES RB1 AND TP53

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Malignant Fibrous Histiocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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