Which Foods are Recommended for Appendiceal Adenocarcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Appendiceal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Appendiceal Adenocarcinoma because of SMAD4 and KRAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Appendiceal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Kale” or “Can I take Lavender and Sesamin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO APPENDICEAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Appendiceal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR APPENDICEAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Appendiceal Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Appendiceal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Appendiceal Adenocarcinoma are in ages between 25 to 88 with an average age of 57. 46.2% of males and 53.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 266; the top genes with mutations and other abnormalities for Appendiceal Adenocarcinoma include genes KRAS, TP53, DNMT3A, PIK3CA and SMAD4. The occurrence frequency distribution for these genes respectively is 29.6%, 24.7%, 13.6%, 9.9% and 8.6%. These tumor genetic details of Appendiceal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Appendiceal Adenocarcinoma.

Significance of Nutrition for Appendiceal Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Appendiceal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Quercetin, Resveratrol, Vitamin C, Delphinidin, Caffeic Acid and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Appendiceal Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Appendiceal Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR APPENDICEAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Appendiceal Adenocarcinoma undergoing chemotherapy treatment

In Appendiceal Adenocarcinoma – the genes KRAS, TP53, DNMT3A, PIK3CA and SMAD4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Appendiceal Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Survival and PI3K-AKT-MTOR Signaling.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Appendiceal Adenocarcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR APPENDICEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Kale?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Kale are Brassinin, Vitamin C, Linolenic Acid, Kaempferol, Sulforaphane and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Survival and PI3K-AKT-MTOR Signaling.

Brassinin can manipulate biochemical pathways Oxidative Stress. Indole-3-carbinol has biological action on biochemical pathways DNA Repair. And so on.

When treating Appendiceal Adenocarcinoma with chemotherapy Radiation – Foods like Cassava are recommended compared to Kale. This is because the active ingredients Brassinin and Indole-3-carbinol in Kale interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER KALE FOR APPENDICEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Feijoa or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Delphinidin, Caffeic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Resveratrol has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Appendiceal Adenocarcinoma with chemotherapy Radiation – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Resveratrol in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR APPENDICEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Oleic Acid, Gamma-linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Appendiceal Adenocarcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR APPENDICEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Appendiceal Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMAD4 and KRAS are two genes whose abnormalities are risk factors for Appendiceal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Appendiceal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Appendiceal Adenocarcinoma gene SMAD4 has causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. And KRAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and Immune Evasion Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMAD4 and KRAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMAD4 and KRAS should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Vitexin, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Quercetin, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitexin has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Appendiceal Adenocarcinoma due to abnormalities in genes SMAD4 and KRAS – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF APPENDICEAL ADENOCARCINOMA DUE TO GENES SMAD4 AND KRAS

Eat more vegetables, Arugula or Carob?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Gallic Acid, Phloroglucinol and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and MAPK Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Appendiceal Adenocarcinoma due to abnormalities in genes SMAD4 and KRAS – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF APPENDICEAL ADENOCARCINOMA DUE TO GENES SMAD4 AND KRAS

Eat more fruits, Orange or Cranberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Quercetin, Vitamin C, Hyperoside and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Appendiceal Adenocarcinoma due to abnormalities in genes SMAD4 and KRAS – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF APPENDICEAL ADENOCARCINOMA DUE TO GENES SMAD4 AND KRAS

Eat more nuts, Pecan Nut or Brazil Nut?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Appendiceal Adenocarcinoma due to abnormalities in genes SMAD4 and KRAS – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF APPENDICEAL ADENOCARCINOMA DUE TO GENES SMAD4 AND KRAS

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Appendiceal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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