Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Angiosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Angiosarcoma because of RYR2 and KDR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Angiosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Dim and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANGIOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Angiosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANGIOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Angiosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Angiosarcoma from cBioPortal. The patients enrolled in the studies for Angiosarcoma are in ages between 1 to 92 with an average age of 53. 95.5% of males and 4.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 1177; the top genes with mutations and other abnormalities for Angiosarcoma include genes TP53, RYR2, MUC16, KDR and RYR3. The occurrence frequency distribution for these genes respectively is 3.2%, 3.2%, 3.0%, 2.7% and 2.5%. These tumor genetic details of Angiosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Angiosarcoma.
Angiosarcoma is a rare and highly aggressive malignant tumor of the lymphatic or vascular endothelial cell. It is less than 2% of all soft tissue sarcomas and mostly affects adults and elderly patients. Angiosarcoma can occur in any location of the body, but the most common sites of occurrence are cutaneous lesions in 60% of the cases, particularly in the head and neck region. It can also present within the soft tissues, and other organs of the body. Angiosarcoma has a high rate of local recurrence and being an aggressive tumor, had the tendency to spread to distant organs, with the lung and brain being the most common sites of metastases. About 16-44% of the cases are diagnosed at an advanced metastatic stage. The 5-year survival rate for patients with angiosarcoma is 30-40% and an overall survival ranging from 6 to 16 months. Treatment for angiosarcoma includes surgery, radiotherapy, chemotherapy and the newer options of targeted therapy and immunotherapy. Supportive care with the right nutrition (foods and natural supplements) aligned to the treatment can help improve patients’ well-being. (Ref: Cao J et al, Am J Cancer Res., 2019; https://www.ncbi.nlm.nih.gov/books/NBK441983/)
Significance of Nutrition for Angiosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Angiosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Quercetin, Hyperoside, Linolenic Acid, Resveratrol, Vitamin C and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Angiosarcoma, activation or inhibition of selected biochemical pathways like Vitamin Metabolism, Cell Cycle, Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Angiosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANGIOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Angiosarcoma undergoing chemotherapy treatment
In Angiosarcoma – the genes TP53, RYR2, MUC16, KDR and RYR3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Angiosarcoma are Vitamin Metabolism, Cell Cycle, Cell Cycle Checkpoints and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Vitamin Metabolism, Cell Cycle, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Delphinidin, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Genistein, Oleic Acid, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.
Genistein can manipulate biochemical pathways Hippo Signaling, DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Extracellular Matrix Remodelling. And so on.
When treating Angiosarcoma with chemotherapy Cyclophosphamide – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Lotus?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A among others. While the active ingredients contained in Lotus are Quercetin, Fisetin, Beta-sitosterol, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Apoptosis and DNA Repair.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Hypoxia and Oxidative Stress. And so on.
When treating Angiosarcoma with chemotherapy Cyclophosphamide – Foods like Cassava are recommended compared to Lotus. This is because the active ingredients Citric Acid and Quercetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER LOTUS FOR ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more fruits, Nance or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Lingonberry are Quercetin, Hyperoside, Linolenic Acid, Resveratrol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and Cell Cycle. Betulin has biological action on biochemical pathways Apoptosis, Cell Survival and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress and Hypoxia. Hyperoside has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Angiosarcoma with chemotherapy Cyclophosphamide – Foods like Nance are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Hyperoside in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER LINGONBERRY FOR ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Linolenic Acid, Cianidanol, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Delphinidin has biological action on biochemical pathways DNA Repair, Growth Factor Signaling and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress and Hypoxia. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Angiosarcoma with chemotherapy Cyclophosphamide – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Angiosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RYR2 and KDR are two genes whose abnormalities are risk factors for Angiosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Angiosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Angiosarcoma gene RYR2 has causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. And KDR has a causative impact on biological pathways like Angiogenesis and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RYR2 and KDR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RYR2 and KDR should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Vitexin among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin E, Daidzein, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitexin has biological action on biochemical pathways Small Molecule Transport, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angiosarcoma due to abnormalities in genes RYR2 and KDR – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANGIOSARCOMA DUE TO GENES RYR2 AND KDR
Eat more vegetables, Jicama or Swede?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Angiogenesis.
Lycopene can manipulate biochemical pathways Small Molecule Transport and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Angiosarcoma due to abnormalities in genes RYR2 and KDR – Foods like Jicama are recommended compared to Swede. This is because the active ingredients Lycopene and Folic Acid in Swede further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER SWEDE FOR REDUCING THE GENETIC RISK OF ANGIOSARCOMA DUE TO GENES RYR2 AND KDR
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Huckleberry?
The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, P-coumaric Acid, Delphinidin and others.
D-limonene can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angiosarcoma due to abnormalities in genes RYR2 and KDR – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF ANGIOSARCOMA DUE TO GENES RYR2 AND KDR
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Angiogenesis.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Angiosarcoma due to abnormalities in genes RYR2 and KDR – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ANGIOSARCOMA DUE TO GENES RYR2 AND KDR
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Angiosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Trends in congenital heart disease in Dallas County births. 1971-1984.
- Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion.
- Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- d -Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.