Which Foods are Recommended for Anaplastic Astrocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Astrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Astrocytoma because of IDH1 and DNMT3A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Anaplastic Astrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Caffeine and Boldo supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC ASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Anaplastic Astrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC ASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Anaplastic Astrocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Anaplastic Astrocytoma from cBioPortal. The patients enrolled in the studies for Anaplastic Astrocytoma are in ages between 1 to 94 with an average age of 53. 60.9% of males and 39.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 1337; the top genes with mutations and other abnormalities for Anaplastic Astrocytoma include genes DNMT3A, IDH1, ATRX, TERT and TET2. The occurrence frequency distribution for these genes respectively is 21.9%, 14.6%, 13.5%, 8.6% and 5.1%. These tumor genetic details of Anaplastic Astrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Astrocytoma.

Anaplastic astrocytoma (Grade III) are brain tumors that arise from astrocytes that are the supporting cells for the neurons in the brain. These tumors are moderately fast-growing and less well-defined than a lower grade astrocytoma that is Grade I or II. These brain tumors are usually diagnosed in adults in the age group between 30 and 50 years. They can occur in any region in the brain. Common symptoms of patients with anaplastic astrocytoma include changes in behavior, headaches, memory loss and seizures. Treatment depends on the location of the tumor and how far it has progressed, and it can include surgery, radiation therapy with temozolomide chemotherapy, anti-angiogenic bevacizumab, tumor treating electric fields and anti-seizure drugs. Supportive care with the right foods and natural supplements can help improve the patients’ well-being. (Ref: https://www.braintumour.ca/brain_tumour_types/anaplastic-astrocytoma/; https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Astrocytoma-Tumors; https://my.clevelandclinic.org/health/diseases/17863-astrocytoma )

Significance of Nutrition for Anaplastic Astrocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Astrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Sapota includes active ingredients Lycopene, Gallic Acid, Vitamin C, Oleic Acid, Beta-sitosterol and others. And Blueberry contains active ingredients Resveratrol, Myricetin, Gallic Acid, Vitamin C, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Anaplastic Astrocytoma, activation or inhibition of selected biochemical pathways like DNA Repair, MAPK Signaling, Oncogenic Cancer Epigenetics, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Astrocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC ASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Anaplastic Astrocytoma undergoing chemotherapy treatment

In Anaplastic Astrocytoma – the genes DNMT3A, IDH1, ATRX, TERT and TET2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Astrocytoma are DNA Repair, MAPK Signaling, Hypoxia and others. Capecitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, MAPK Signaling, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Vitamin C, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Cianidanol, Butyric Acid, Astragalin and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Hypoxia and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways NFKB Signaling and MAPK Signaling. And so on.

When treating Anaplastic Astrocytoma with chemotherapy Capecitabine – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Vitamin A and Palmitic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR ANAPLASTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more vegetables, Amaranth or Yardlong Bean?

Vegetables are an important part of many diets. The active ingredients contained in Amaranth are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Isoquercitrin among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Hypoxia and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Anaplastic Astrocytoma with chemotherapy Capecitabine – Foods like Amaranth are recommended compared to Yardlong Bean. This is because the active ingredients Vitamin A and Folic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Amaranth support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: AMARANTH IS RECOMMENDED OVER YARDLONG BEAN FOR ANAPLASTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more fruits, Blueberry or Sapota?

Fruits are an important part of many diets. The active ingredients contained in Blueberry are Resveratrol, Myricetin, Gallic Acid, Vitamin C, Quercetin among others. While the active ingredients contained in Sapota are Lycopene, Gallic Acid, Vitamin C, Oleic Acid, Beta-sitosterol and others.

Gallic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Anaplastic Astrocytoma with chemotherapy Capecitabine – Foods like Blueberry are recommended compared to Sapota. This is because the active ingredients Vitamin A and Folic Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gallic Acid and Vitamin C contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER SAPOTA FOR ANAPLASTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more nuts, Almond or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Salicylic Acid, Stigmasterol and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Hypoxia. Quercetin has biological action on biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.

When treating Anaplastic Astrocytoma with chemotherapy Capecitabine – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR ANAPLASTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Anaplastic Astrocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH1 and DNMT3A are two genes whose abnormalities are risk factors for Anaplastic Astrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Astrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Astrocytoma gene IDH1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And DNMT3A has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Amino Acid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH1 and DNMT3A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH1 and DNMT3A should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling. And so on.

For genetic risk of Anaplastic Astrocytoma due to abnormalities in genes IDH1 and DNMT3A – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC ASTROCYTOMA DUE TO GENES IDH1 AND DNMT3A

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Vitamin C, Betulinic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Anaplastic Astrocytoma due to abnormalities in genes IDH1 and DNMT3A – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC ASTROCYTOMA DUE TO GENES IDH1 AND DNMT3A

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Hyperoside and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Anaplastic Astrocytoma due to abnormalities in genes IDH1 and DNMT3A – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC ASTROCYTOMA DUE TO GENES IDH1 AND DNMT3A

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Quercetin, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Anaplastic Astrocytoma due to abnormalities in genes IDH1 and DNMT3A – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ANAPLASTIC ASTROCYTOMA DUE TO GENES IDH1 AND DNMT3A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Anaplastic Astrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Tmb Mskcc 2018
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
• Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
• Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
• Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Research progress on the anticancer effects of vitamin K2.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.