Which Foods are Recommended for Alveolar Rhabdomyosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Alveolar Rhabdomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Alveolar Rhabdomyosarcoma because of ARID5B and MED12 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Alveolar Rhabdomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Galangal and Licorice supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ALVEOLAR RHABDOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Alveolar Rhabdomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ALVEOLAR RHABDOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Alveolar Rhabdomyosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Alveolar Rhabdomyosarcoma from cBioPortal. The patients enrolled in the studies for Alveolar Rhabdomyosarcoma are in ages between 7 to 18 with an average age of 16. 49.3% of males and 50.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 42; the top genes with mutations and other abnormalities for Alveolar Rhabdomyosarcoma include genes ARID5B, MED12, NOTCH1, ZFHX3 and APC. The occurrence frequency distribution for these genes respectively is 12.5%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Alveolar Rhabdomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Alveolar Rhabdomyosarcoma.

Rhabdomyosarcoma is a common soft tissue malignant tumor in children and adolescents, while it is exceedingly rare in adults. Nevertheless, the outcome in adults is very poor, when compared to the outcomes in children, in whom significant improvements in treatments have been achieved. The sites of adult rhabdomyosarcoma are the extremities while in children it is in the head and neck areas. The prognosis for adult alveolar rhabdomyosarcoma is poor. More than 60% of adult patients have regional or distant metastasis at the initial diagnosis. It is usually very difficult or impossible to excise the tumor mass that develops due to its spread locally or to distant regions at the time of diagnosis. The 5-year survival rate for adult alveolar rhabdomyosarcoma is less than 8% in cases of head and neck rhabdomyosarcoma. The treatment protocols for adult rhabdomyosarcoma are not established. Treatment modalities include surgery, chemotherapy, radiation therapy. Supportive care with the right nutrition (foods and natural supplements) aligned to the cancer stage and treatment context can help improve patients’ well-being. (Ref: Jin-Ho J et al, Medicine, 2018; https://www.ncbi.nlm.nih.gov/books/NBK507721/; https://my.clevelandclinic.org/health/diseases/6226-rhabdomyosarcoma)

Significance of Nutrition for Alveolar Rhabdomyosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Alveolar Rhabdomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Coconut includes active ingredients Vitamin E, Capric Acid, Lauric Acid, Myristic Acid, Palmitic Acid and others. And Blackberry contains active ingredients Myricetin, Ellagic Acid, Gallic Acid, Quercetin, Hyperoside and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Alveolar Rhabdomyosarcoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, TGFB Signaling, Notch Signaling, RUNX Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Alveolar Rhabdomyosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ALVEOLAR RHABDOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Alveolar Rhabdomyosarcoma undergoing chemotherapy treatment

In Alveolar Rhabdomyosarcoma – the genes ARID5B, MED12, NOTCH1, ZFHX3 and APC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Alveolar Rhabdomyosarcoma are MAPK Signaling and others. Dactinomycin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Linolenic Acid, Quercetin, Stigmasterol, Kaempferol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Linolenic Acid, Fisetin, Quercetin, 7-8-dihydroxyflavone, Stigmasterol and others.

Quercetin can manipulate biochemical pathways MAPK Signaling. Stigmasterol has biological action on biochemical pathways MAPK Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Alveolar Rhabdomyosarcoma with chemotherapy Dactinomycin – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Folic Acid in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR ALVEOLAR RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Isorhamnetin, Pelargonidin, Quercetin, Sulforaphane, Delphinidin among others. While the active ingredients contained in Celery are Angelicin, Linolenic Acid, Apigenin, Quercetin, Kaempferol and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling. Isorhamnetin has biological action on biochemical pathways MAPK Signaling.

Cynaroside can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Alveolar Rhabdomyosarcoma with chemotherapy Dactinomycin – Foods like Cabbage are recommended compared to Celery. This is because the active ingredients Cynaroside and Folic Acid in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Isorhamnetin contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CELERY FOR ALVEOLAR RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more fruits, Blackberry or Coconut?

Fruits are an important part of many diets. The active ingredients contained in Blackberry are Myricetin, Ellagic Acid, Gallic Acid, Quercetin, Hyperoside among others. While the active ingredients contained in Coconut are Vitamin E, Capric Acid, Lauric Acid, Myristic Acid, Palmitic Acid and others.

Scopoletin can manipulate biochemical pathways MAPK Signaling. Cianidanol has biological action on biochemical pathways MAPK Signaling.

Lauric Acid can manipulate biochemical pathways MAPK Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Alveolar Rhabdomyosarcoma with chemotherapy Dactinomycin – Foods like Blackberry are recommended compared to Coconut. This is because the active ingredients Lauric Acid and Myristic Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Scopoletin and Cianidanol contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER COCONUT FOR ALVEOLAR RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more nuts, Walnut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Myricetin, Ellagic Acid, Gallic Acid, Linolenic Acid, D-limonene among others. While the active ingredients contained in Acorn are Gallic Acid, Quercetin, Vitamin C, Quercitrin, Folic Acid and others.

Myricetin can manipulate biochemical pathways MAPK Signaling. Ellagic Acid has biological action on biochemical pathways MAPK Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Alveolar Rhabdomyosarcoma with chemotherapy Dactinomycin – Foods like Walnut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Myricetin and Ellagic Acid contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER ACORN FOR ALVEOLAR RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Alveolar Rhabdomyosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID5B and MED12 are two genes whose abnormalities are risk factors for Alveolar Rhabdomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Alveolar Rhabdomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Alveolar Rhabdomyosarcoma gene ARID5B has causative impact on biological pathways like Suppressive Histone Methylation. And MED12 has a causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID5B and MED12 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID5B and MED12 should be avoided.

Eat more pulses, Scarlet Bean or Pigeon Pea?

The active ingredients contained in Scarlet Bean are Linolenic Acid, Oleic Acid, Vitamin C, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Genistein, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and TGFB Signaling. And so on.

For genetic risk of Alveolar Rhabdomyosarcoma due to abnormalities in genes ARID5B and MED12 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF ALVEOLAR RHABDOMYOSARCOMA DUE TO GENES ARID5B AND MED12

Eat more vegetables, Jicama or Parsnip?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Psoralen and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling and Growth Factor Signaling. And so on.

For genetic risk of Alveolar Rhabdomyosarcoma due to abnormalities in genes ARID5B and MED12 – Foods like Jicama are recommended compared to Parsnip. This is because the active ingredients Ferulic Acid and Linoleic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF ALVEOLAR RHABDOMYOSARCOMA DUE TO GENES ARID5B AND MED12

Eat more fruits, Feijoa or Date?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Date are Apigenin, Quercetin, Protocatechuic Acid, Lupeol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Apigenin can manipulate biochemical pathways TGFB Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Alveolar Rhabdomyosarcoma due to abnormalities in genes ARID5B and MED12 – Foods like Feijoa are recommended compared to Date. This is because the active ingredients Apigenin and Ferulic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF ALVEOLAR RHABDOMYOSARCOMA DUE TO GENES ARID5B AND MED12

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and Cell Cycle Checkpoints.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Alveolar Rhabdomyosarcoma due to abnormalities in genes ARID5B and MED12 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ALVEOLAR RHABDOMYOSARCOMA DUE TO GENES ARID5B AND MED12

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Alveolar Rhabdomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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