Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adenoid Cystic Carcinoma Of The Lung when undergoing chemotherapy or when you determine you have a genetic risk for developing Adenoid Cystic Carcinoma Of The Lung because of NOTCH1 and ARID1A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Adenoid Cystic Carcinoma Of The Lung which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lemon” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADENOID CYSTIC CARCINOMA OF THE LUNG, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Adenoid Cystic Carcinoma Of The Lung is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADENOID CYSTIC CARCINOMA OF THE LUNG, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Adenoid Cystic Carcinoma Of The Lung
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Adenoid Cystic Carcinoma Of The Lung from cBioPortal. 36.8% of males and 63.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 76; the top genes with mutations and other abnormalities for Adenoid Cystic Carcinoma Of The Lung include genes NOTCH1, ARID1A, BCOR, KMT2C and ARID1B. The occurrence frequency distribution for these genes respectively is 17.3%, 16.0%, 16.0%, 13.3% and 12.0%. These tumor genetic details of Adenoid Cystic Carcinoma Of The Lung are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adenoid Cystic Carcinoma Of The Lung.
Significance of Nutrition for Adenoid Cystic Carcinoma Of The Lung
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adenoid Cystic Carcinoma Of The Lung. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lemon includes active ingredients D-limonene, Diosmetin, Auraptene, Vitamin C, Hesperidin and others. And Nance contains active ingredients Vitamin C, Vitamin A, Betulin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Adenoid Cystic Carcinoma Of The Lung, activation or inhibition of selected biochemical pathways like C-type Lectin Receptor Signaling, RUNX Signaling, PI3K-AKT-MTOR Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adenoid Cystic Carcinoma Of The Lung, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADENOID CYSTIC CARCINOMA OF THE LUNG – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Adenoid Cystic Carcinoma Of The Lung undergoing chemotherapy treatment
In Adenoid Cystic Carcinoma Of The Lung – the genes NOTCH1, ARID1A, BCOR, KMT2C and ARID1B have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adenoid Cystic Carcinoma Of The Lung are C-type Lectin Receptor Signaling, RUNX Signaling, Notch Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers C-type Lectin Receptor Signaling, RUNX Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linoleic Acid, Genistein, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Adenoid Cystic Carcinoma Of The Lung with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ADENOID CYSTIC CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Cauliflower?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Indole-3-carbinol, Beta-sitosterol, Brassinin among others. While the active ingredients contained in Cauliflower are Indole-3-carbinol, Beta-sitosterol, Brassinin, Vitamin C, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Cell Survival and MAPK Signaling.
Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Adenoid Cystic Carcinoma Of The Lung with chemotherapy Carboplatin – Foods like Cabbage are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CAULIFLOWER FOR ADENOID CYSTIC CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Nance or Lemon?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Vitamin A, Betulin among others. While the active ingredients contained in Lemon are D-limonene, Diosmetin, Auraptene, Vitamin C, Hesperidin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin A has biological action on biochemical pathways NFKB Signaling, WNT Beta Catenin Signaling and Vitamin D Signaling.
D-limonene can manipulate biochemical pathways Oxidative Stress. Myrcene has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Adenoid Cystic Carcinoma Of The Lung with chemotherapy Carboplatin – Foods like Nance are recommended compared to Lemon. This is because the active ingredients D-limonene and Myrcene in Lemon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER LEMON FOR ADENOID CYSTIC CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linoleic Acid, Linolenic Acid, Cianidanol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and P53 Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Adenoid Cystic Carcinoma Of The Lung with chemotherapy Carboplatin – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Linolenic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR ADENOID CYSTIC CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Adenoid Cystic Carcinoma Of The Lung
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and ARID1A are two genes whose abnormalities are risk factors for Adenoid Cystic Carcinoma Of The Lung. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adenoid Cystic Carcinoma Of The Lung can be used as a guide for coming up with a recommended personalized nutrition plan. For Adenoid Cystic Carcinoma Of The Lung gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And ARID1A has a causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and ARID1A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and ARID1A should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Daidzein, Beta-sitosterol, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Adenoid Cystic Carcinoma Of The Lung due to abnormalities in genes NOTCH1 and ARID1A – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA OF THE LUNG DUE TO GENES NOTCH1 AND ARID1A
Eat more vegetables, Jicama or Chicory?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Adenoid Cystic Carcinoma Of The Lung due to abnormalities in genes NOTCH1 and ARID1A – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA OF THE LUNG DUE TO GENES NOTCH1 AND ARID1A
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Cherimoya or Cranberry?
The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Cranberry are P-coumaric Acid, Resveratrol, Vitamin C, Ellagic Acid, Hyperoside and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Adenoid Cystic Carcinoma Of The Lung due to abnormalities in genes NOTCH1 and ARID1A – Foods like Cherimoya are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA OF THE LUNG DUE TO GENES NOTCH1 AND ARID1A
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Ellagic Acid, Oleic Acid, Quercetin and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Adenoid Cystic Carcinoma Of The Lung due to abnormalities in genes NOTCH1 and ARID1A – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA OF THE LUNG DUE TO GENES NOTCH1 AND ARID1A
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Adenoid Cystic Carcinoma Of The Lung by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Acc 2019
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.