Which Foods are Recommended for Thymic Epithelial Tumor?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Thymic Epithelial Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Thymic Epithelial Tumor because of ITGB2 and GABBR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Thymic Epithelial Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Elderberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Guggul and Stevia supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THYMIC EPITHELIAL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Thymic Epithelial Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR THYMIC EPITHELIAL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Thymic Epithelial Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Thymic Epithelial Tumor from cBioPortal. The patients enrolled in the studies for Thymic Epithelial Tumor are in ages between 23 to 76 with an average age of 53. 48.3% of males and 51.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 32; the top genes with mutations and other abnormalities for Thymic Epithelial Tumor include genes TP53, CDKN2A, ITGB2, GABBR2 and CYLD. The occurrence frequency distribution for these genes respectively is 10.7%, 7.1%, 7.1%, 7.1% and 7.1%. These tumor genetic details of Thymic Epithelial Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Thymic Epithelial Tumor.

Significance of Nutrition for Thymic Epithelial Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Thymic Epithelial Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Elderberry includes active ingredients Quercetin, Vitamin C, Linolenic Acid, Lupeol, Betulinic Acid and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Thymic Epithelial Tumor, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Hypoxia, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Thymic Epithelial Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THYMIC EPITHELIAL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Thymic Epithelial Tumor undergoing chemotherapy treatment

In Thymic Epithelial Tumor – the genes TP53, CDKN2A, ITGB2, GABBR2 and CYLD have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Thymic Epithelial Tumor are RAS-RAF Signaling, Hypoxia, Focal Adhesion and others. Lenvatinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Hypoxia, Focal Adhesion so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Vitamin C, Linolenic Acid, Betulinic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Oleic Acid, Stigmasterol, Beta-sitosterol, Linoleic Acid and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Hypoxia, RAS-RAF Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways Focal Adhesion. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Thymic Epithelial Tumor with chemotherapy Lenvatinib – Foods like Winged Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Oleic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER MOTH BEAN FOR THYMIC EPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY LENVATINIB FOR SOME CONDITIONS.

Eat more vegetables, Cauliflower or Okra?

Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Vitamin C, Linolenic Acid, Glucaric Acid, Sulforaphane, Oleic Acid among others. While the active ingredients contained in Okra are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.

Vitamin A can manipulate biochemical pathways Focal Adhesion. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Thymic Epithelial Tumor with chemotherapy Lenvatinib – Foods like Cauliflower are recommended compared to Okra. This is because the active ingredients Vitamin A and Oleic Acid in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER OKRA FOR THYMIC EPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY LENVATINIB FOR SOME CONDITIONS.

Eat more fruits, Orange or Elderberry?

Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Elderberry are Quercetin, Vitamin C, Linolenic Acid, Lupeol, Betulinic Acid and others.

D-limonene can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and RAS-RAF Signaling.

Rutin can manipulate biochemical pathways Focal Adhesion. Lupeol has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Thymic Epithelial Tumor with chemotherapy Lenvatinib – Foods like Orange are recommended compared to Elderberry. This is because the active ingredients Rutin and Lupeol in Elderberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER ELDERBERRY FOR THYMIC EPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY LENVATINIB FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Oleic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Gallic Acid, Vitamin B3, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

When treating Thymic Epithelial Tumor with chemotherapy Lenvatinib – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR THYMIC EPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY LENVATINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Thymic Epithelial Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ITGB2 and GABBR2 are two genes whose abnormalities are risk factors for Thymic Epithelial Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Thymic Epithelial Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Thymic Epithelial Tumor gene ITGB2 has causative impact on biological pathways like Focal Adhesion and TGFB Signaling. And GABBR2 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ITGB2 and GABBR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ITGB2 and GABBR2 should be avoided.

Eat more pulses, Common Pea or Fava Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Fava Bean are Daidzein, Quercetin, Beta-sitosterol, Ferulic Acid, P-coumaric Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.

Vitamin A can manipulate biochemical pathways Focal Adhesion. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Thymic Epithelial Tumor due to abnormalities in genes ITGB2 and GABBR2 – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Vitamin A and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF THYMIC EPITHELIAL TUMOR DUE TO GENES ITGB2 AND GABBR2

Eat more vegetables, Burdock or Beetroot?

The active ingredients contained in Burdock are Lupeol, Arctigenin, Dehydrocostus Lactone, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Apoptosis, Extracellular Matrix Remodelling and TGFB Signaling. Caffeic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle.

Vitamin A can manipulate biochemical pathways Focal Adhesion. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Thymic Epithelial Tumor due to abnormalities in genes ITGB2 and GABBR2 – Foods like Burdock are recommended compared to Beetroot. This is because the active ingredients Vitamin A and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Caffeic Acid contained in Burdock together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BURDOCK IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF THYMIC EPITHELIAL TUMOR DUE TO GENES ITGB2 AND GABBR2

Eat more fruits, Blueberry or Watermelon?

The active ingredients contained in Blueberry are Vitamin E, Quercetin, Hyperoside, Eugenol, Ferulic Acid among others. While the active ingredients contained in Watermelon are Lycopene, Cucurbitacin E, Linolenic Acid, Vitamin C, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Cianidanol has biological action on biochemical pathways TGFB Signaling, P53 Signaling and Cell Cycle Checkpoints.

Lycopene can manipulate biochemical pathways Extracellular Matrix Remodelling. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

For genetic risk of Thymic Epithelial Tumor due to abnormalities in genes ITGB2 and GABBR2 – Foods like Blueberry are recommended compared to Watermelon. This is because the active ingredients Lycopene and Vitamin A in Watermelon further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cianidanol contained in Blueberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER WATERMELON FOR REDUCING THE GENETIC RISK OF THYMIC EPITHELIAL TUMOR DUE TO GENES ITGB2 AND GABBR2

Eat more nuts, Pistachio or Peanut?

The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Beta-sitosterol, Ferulic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.

Vitamin A can manipulate biochemical pathways Focal Adhesion. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Thymic Epithelial Tumor due to abnormalities in genes ITGB2 and GABBR2 – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF THYMIC EPITHELIAL TUMOR DUE TO GENES ITGB2 AND GABBR2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Thymic Epithelial Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Tet Nci 2014
• A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.
• Cryptorchidism: a pediatrician’s view.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.
• Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Research progress on the anticancer effects of vitamin K2.
• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Thrombin inhibitory activity of some polyphenolic compounds.
• Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
• Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
• Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.