Foods for Thymic Epithelial Tumor!

Introduction

Foods for Thymic Epithelial Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Thymic Epithelial Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Thymic Epithelial Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Thymic Epithelial Tumor?

For example does it matter if vegetable Bitter Gourd is consumed more compared to Mexican Groundcherry? Does it make any difference if fruit Pummelo is preferred over Lemon? Also if similar choices are made for nuts/seeds like Black Walnut over Chestnut and for pulses like Alfalfa over Yardlong Bean. And if what I eat matters – then how does one identify foods which are recommended for Thymic Epithelial Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Thymic Epithelial Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lycopene, Quercetin, Protocatechuic Acid. And Lemon contains active ingredients D-limonene, Curcumin, Linalool, Protocatechuic Acid, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Thymic Epithelial Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Thymic Epithelial Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Thymic Epithelial Tumor?

Personalized nutrition for cancers like Thymic Epithelial Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Thymic Epithelial Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Thymic Epithelial Tumor

All cancers like Thymic Epithelial Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Thymic Epithelial Tumor. Biochemical pathways like RAS-RAF Signaling, Hypoxia, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Thymic Epithelial Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Thymic Epithelial Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Thymic Epithelial Tumor when taking cancer treatment Lenvatinib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, CDKN2A, ITGB2, GABBR2 and CYLD are the top ranked reported genes for Thymic Epithelial Tumor. TP53 is reported in 10.7 % of the representative patients across all clinical trials. And CDKN2A is reported in 7.1 %. The combined population patient data cover ages from 23 to 76. 48.3 % of the patient data are identified as men. The Thymic Epithelial Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Thymic Epithelial Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BITTER GOURD or MEXICAN GROUNDCHERRY?

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Protocatechuic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling and MYC Signaling and others. Bitter Gourd is recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib. This is because Bitter Gourd modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Apigenin, Curcumin, Myricetin, Protocatechuic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and MYC Signaling and others. Mexican Groundcherry is not recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR Thymic Epithelial Tumor AND TREATMENT Lenvatinib.

Choose Fruit LEMON or PUMMELO?

Fruit Lemon contains many active ingredients or bioactives such as D-limonene, Curcumin, Linalool, Protocatechuic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia, MAPK Signaling and MYC Signaling and others. Lemon is recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib. This is because Lemon modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lycopene, Quercetin, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and MYC Signaling and others. Pummelo is not recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT LEMON IS RECOMMENDED OVER PUMMELO FOR Thymic Epithelial Tumor AND TREATMENT Lenvatinib.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Ellagic Acid, Apigenin, Curcumin, Myricetin, Quercetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Black Walnut is recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Apigenin, Curcumin, Lycopene, Myricetin. These active ingredients manipulate various biochemical pathways like Focal Adhesion and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended for Thymic Epithelial Tumor when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR Thymic Epithelial Tumor AND TREATMENT Lenvatinib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Thymic Epithelial Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or ALLIUM?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, MAPK Signaling and MYC Signaling and others. Wild Carrot is recommended for risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Allium are Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle and PI3K-AKT-MTOR Signaling and others. Allium is not recommended when risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER ALLIUM FOR CDKN2A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or LICHEE?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and Angiogenesis and others. Java Plum is recommended for risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Lichee are Apigenin, Curcumin, Lupeol, Daidzein, Linalool. These active ingredients manipulate various biochemical pathways like Cell Cycle, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Lichee is not recommended when risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER LICHEE FOR CDKN2A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Focal Adhesion and Stem Cell Signaling and others. Butternut is recommended for risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Ellagic Acid, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. European Chestnut is not recommended when risk of Thymic Epithelial Tumor when associated genetic risk is CDKN2A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR CDKN2A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Thymic Epithelial Tumor. Thymic Epithelial Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Thymic Epithelial Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Bitter Gourd contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Thymic Epithelial Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Tet Nci 2014
• A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Research progress on the anticancer effects of vitamin K2.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
• Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
• Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.