Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Teratoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Teratoma because of TNFRSF14 and CD79B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Teratoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Grapefruit in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Buckthorn and Horse Chestnut supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO TERATOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Teratoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR TERATOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Teratoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Teratoma from cBioPortal. The patients enrolled in the studies for Teratoma are in ages between 23 to 36 with an average age of 28. 91.7% of males and 8.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 14; the top genes with mutations and other abnormalities for Teratoma include genes PTEN, TNFRSF14, TP53, CD79B and EPHA5. The occurrence frequency distribution for these genes respectively is 14.3%, 14.3%, 14.3%, 14.3% and 14.3%. These tumor genetic details of Teratoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Teratoma.
Teratoma, is a rare type of germ cell tumor that starts in the reproductive cells. Teratoma may be cancerous (malignant) or noncancerous (benign) and they can affect people of all ages. Teratomas most commonly form in the ovaries (ovarian teratoma), testes (testicular teratoma) or tailbone (sacrococcygeal teratoma), but they can occur anywhere in the body. Teratoma symptoms may include pain, bleeding, swelling and slightly elevated levels of hormone beta-human chorionic gonadotropin (HCG) and levels of tumor marker alpha fetoprotein (AFP). Teratomas have excellent survival rates. Treatment involves surgical removal. Cancerous teratomas may require chemotherapy, radiation therapy or other cancer treatments, supported by the right nutrition (food and supplements). (Ref: https://my.clevelandclinic.org/health/diseases/22074-teratoma)
Significance of Nutrition for Teratoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Teratoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others. And Grapefruit contains active ingredients Naringin, Oleic Acid, Linolenic Acid, Naringenin, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Teratoma, activation or inhibition of selected biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, C-type Lectin Receptor Signaling, Inositol Phosphate Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Teratoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR TERATOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Teratoma undergoing chemotherapy treatment
In Teratoma – the genes PTEN, TNFRSF14, TP53, CD79B and EPHA5 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Teratoma are DNA Repair, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lentils?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Oleic Acid, Daidzein, Vitamin C among others. While the active ingredients contained in Lentils are Esculin, Beta-sitosterol, Oleic Acid, Daidzein, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
When treating Teratoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Folic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LENTILS FOR TERATOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Jute are Oleic Acid, Vitamin C, Linolenic Acid, Quercetin, Vitamin B3 and others.
Kaempferol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin B3 can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Teratoma with chemotherapy Radiation – Foods like Arugula are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Folic Acid in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER JUTE FOR TERATOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Grapefruit or Fig?
Fruits are an important part of many diets. The active ingredients contained in Grapefruit are Naringin, Oleic Acid, Linolenic Acid, Naringenin, Linoleic Acid among others. While the active ingredients contained in Fig are Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others.
Naringin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Naringenin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Teratoma with chemotherapy Radiation – Foods like Grapefruit are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Naringin and Naringenin contained in Grapefruit support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAPEFRUIT IS RECOMMENDED OVER FIG FOR TERATOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Cashew Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Butyric Acid, Palmitic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Teratoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CASHEW NUT FOR TERATOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Teratoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TNFRSF14 and CD79B are two genes whose abnormalities are risk factors for Teratoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Teratoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Teratoma gene TNFRSF14 has causative impact on biological pathways like . And CD79B has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TNFRSF14 and CD79B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TNFRSF14 and CD79B should be avoided.
Eat more pulses, Mung Bean or Yellow Wax Bean?
The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Linolenic Acid, Vitexin, Stigmasterol among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Ferulic Acid, Vitamin C, Palmitic Acid, Butyric Acid and others.
Quercetin can manipulate biochemical pathways NFKB Signaling, Apoptosis and EPHRIN Signaling. Vitexin has biological action on biochemical pathways Cell Survival, MYC Signaling and Calcium Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Teratoma due to abnormalities in genes TNFRSF14 and CD79B – Foods like Mung Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF TERATOMA DUE TO GENES TNFRSF14 AND CD79B
Eat more vegetables, Sweet Potato or Swede?
The active ingredients contained in Sweet Potato are Quercetin, Salicylic Acid, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways NFKB Signaling, MYC Signaling and Apoptosis.
Lycopene can manipulate biochemical pathways Calcium Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Teratoma due to abnormalities in genes TNFRSF14 and CD79B – Foods like Sweet Potato are recommended compared to Swede. This is because the active ingredients Lycopene and Folic Acid in Swede further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin A contained in Sweet Potato together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SWEET POTATO IS RECOMMENDED OVER SWEDE FOR REDUCING THE GENETIC RISK OF TERATOMA DUE TO GENES TNFRSF14 AND CD79B
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Lingonberry or Lemon?
The active ingredients contained in Lingonberry are Resveratrol, Quercetin, Oleic Acid, Hyperoside, Linolenic Acid among others. While the active ingredients contained in Lemon are Hesperidin, Oleic Acid, Diosmetin, D-limonene, Eucalyptol and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Survival. Quercetin has biological action on biochemical pathways EPHRIN Signaling, MYC Signaling and Calcium Signaling.
Myrcene can manipulate biochemical pathways Calcium Signaling. Syringin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Teratoma due to abnormalities in genes TNFRSF14 and CD79B – Foods like Lingonberry are recommended compared to Lemon. This is because the active ingredients Myrcene and Syringin in Lemon further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Quercetin contained in Lingonberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: LINGONBERRY IS RECOMMENDED OVER LEMON FOR REDUCING THE GENETIC RISK OF TERATOMA DUE TO GENES TNFRSF14 AND CD79B
Eat more nuts, Pine Nut or Brazil Nut?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Survival. Vitamin K has biological action on biochemical pathways MYC Signaling, Calcium Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Teratoma due to abnormalities in genes TNFRSF14 and CD79B – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF TERATOMA DUE TO GENES TNFRSF14 AND CD79B
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Teratoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.