Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Spindle Cell Carcinoma Of The Lung when undergoing chemotherapy or when you determine you have a genetic risk for developing Spindle Cell Carcinoma Of The Lung because of EPHA5 and ESR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Spindle Cell Carcinoma Of The Lung which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Lemon in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Guggul and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SPINDLE CELL CARCINOMA OF THE LUNG, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Spindle Cell Carcinoma Of The Lung is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SPINDLE CELL CARCINOMA OF THE LUNG, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Spindle Cell Carcinoma Of The Lung
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Spindle Cell Carcinoma Of The Lung from cBioPortal. From a patient sample size of 3; the top genes with mutations and other abnormalities for Spindle Cell Carcinoma Of The Lung include genes TP53, EPHA5, ESR1, ARID1B and AMER1. The occurrence frequency distribution for these genes respectively is 100.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Spindle Cell Carcinoma Of The Lung are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Spindle Cell Carcinoma Of The Lung.
Significance of Nutrition for Spindle Cell Carcinoma Of The Lung
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Spindle Cell Carcinoma Of The Lung. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Quercetin, Vitamin C, Oleic Acid, Hyperoside, Linolenic Acid and others. And Lemon contains active ingredients Modified Citrus Pectin, D-limonene, Vitamin C, Hesperidin, Eriodictyol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Spindle Cell Carcinoma Of The Lung, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Angiogenesis, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Spindle Cell Carcinoma Of The Lung, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SPINDLE CELL CARCINOMA OF THE LUNG – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Spindle Cell Carcinoma Of The Lung undergoing chemotherapy treatment
In Spindle Cell Carcinoma Of The Lung – the genes TP53, EPHA5, ESR1, ARID1B and AMER1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Spindle Cell Carcinoma Of The Lung are RAS-RAF Signaling, Angiogenesis, MAPK Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Angiogenesis, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Vitexin, Stigmasterol, Glucaric Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.
Quercetin can manipulate biochemical pathways DNA Repair, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.
When treating Spindle Cell Carcinoma Of The Lung with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR SPINDLE CELL CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Lotus?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Vitamin C, Oleic Acid, Rutin, Linolenic Acid among others. While the active ingredients contained in Lotus are Quercetin, Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways DNA Repair, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Spindle Cell Carcinoma Of The Lung with chemotherapy Radiation – Foods like Asparagus are recommended compared to Lotus. This is because the active ingredients Fisetin and Linoleic Acid in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER LOTUS FOR SPINDLE CELL CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Lemon or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Lemon are Modified Citrus Pectin, D-limonene, Vitamin C, Hesperidin, Eriodictyol among others. While the active ingredients contained in Lingonberry are Quercetin, Vitamin C, Oleic Acid, Hyperoside, Linolenic Acid and others.
D-limonene can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Angiogenesis, RAS-RAF Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Spindle Cell Carcinoma Of The Lung with chemotherapy Radiation – Foods like Lemon are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Linoleic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Lemon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: LEMON IS RECOMMENDED OVER LINGONBERRY FOR SPINDLE CELL CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, MAPK Signaling and RAS-RAF Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Spindle Cell Carcinoma Of The Lung with chemotherapy Radiation – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR SPINDLE CELL CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Spindle Cell Carcinoma Of The Lung
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EPHA5 and ESR1 are two genes whose abnormalities are risk factors for Spindle Cell Carcinoma Of The Lung. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Spindle Cell Carcinoma Of The Lung can be used as a guide for coming up with a recommended personalized nutrition plan. For Spindle Cell Carcinoma Of The Lung gene EPHA5 has causative impact on biological pathways like . And ESR1 has a causative impact on biological pathways like Growth Factor Signaling and Oncogenic Cancer Epigenetics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EPHA5 and ESR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EPHA5 and ESR1 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol, Vitamin C among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Spindle Cell Carcinoma Of The Lung due to abnormalities in genes EPHA5 and ESR1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF SPINDLE CELL CARCINOMA OF THE LUNG DUE TO GENES EPHA5 AND ESR1
Eat more vegetables, Arugula or Bell Pepper?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Linolenic Acid, Oleic Acid, Vitamin C, Capsaicin and others.
Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.
Capsaicin can manipulate biochemical pathways MAPK Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Spindle Cell Carcinoma Of The Lung due to abnormalities in genes EPHA5 and ESR1 – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Vitamin E in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF SPINDLE CELL CARCINOMA OF THE LUNG DUE TO GENES EPHA5 AND ESR1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Raspberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Spindle Cell Carcinoma Of The Lung due to abnormalities in genes EPHA5 and ESR1 – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF SPINDLE CELL CARCINOMA OF THE LUNG DUE TO GENES EPHA5 AND ESR1
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Linolenic Acid, Rhamnetin, Oleic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, EPHRIN Signaling and MYC Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Spindle Cell Carcinoma Of The Lung due to abnormalities in genes EPHA5 and ESR1 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin E in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SPINDLE CELL CARCINOMA OF THE LUNG DUE TO GENES EPHA5 AND ESR1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Spindle Cell Carcinoma Of The Lung by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.