Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Prostate Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Prostate Adenocarcinoma because of SPOP and PTEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Prostate Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Watermelon” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Vitamin D3 and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PROSTATE ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Prostate Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PROSTATE ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Prostate Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Prostate Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Prostate Adenocarcinoma are in ages between 32 to 95 with an average age of 64. 97.3% of males and 2.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 11530; the top genes with mutations and other abnormalities for Prostate Adenocarcinoma include genes DNMT3A, TET2, SPOP, PTEN and KMT2C. The occurrence frequency distribution for these genes respectively is 3.0%, 1.2%, 0.9%, 0.8% and 0.6%. These tumor genetic details of Prostate Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Prostate Adenocarcinoma.
Significance of Nutrition for Prostate Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Prostate Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Watermelon includes active ingredients Cucurbitacin E, Lycopene, Linolenic Acid, Oleic Acid, Vitamin C and others. And Pomegranate contains active ingredients Ellagic Acid, Betulinic Acid, Apigenin, Beta-sitosterol, Corilagin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Prostate Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Focal Adhesion, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Prostate Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PROSTATE ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Prostate Adenocarcinoma undergoing chemotherapy treatment
In Prostate Adenocarcinoma – the genes DNMT3A, TET2, SPOP, PTEN and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Prostate Adenocarcinoma are Cell Cycle, Focal Adhesion, Extracellular Matrix Remodelling and others. Mitoxantrone is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Focal Adhesion, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Beta-sitosterol, Lupeol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Genistein, Vitamin C, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Vitamin C has biological action on biochemical pathways Cell Cycle, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.
Genistein can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Prostate Adenocarcinoma with chemotherapy Mitoxantrone – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR PROSTATE ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY MITOXANTRONE FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Chlorogenic Acid, Vanillic Acid, Protocatechuic Acid among others. While the active ingredients contained in Endive are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Kaempferol and others.
Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Beta-carotene has biological action on biochemical pathways Cell Cycle, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Focal Adhesion. And so on.
When treating Prostate Adenocarcinoma with chemotherapy Mitoxantrone – Foods like Arrowroot are recommended compared to Endive. This is because the active ingredients Vitamin A and Oleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER ENDIVE FOR PROSTATE ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY MITOXANTRONE FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Watermelon?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Ellagic Acid, Betulinic Acid, Apigenin, Beta-sitosterol, Corilagin among others. While the active ingredients contained in Watermelon are Cucurbitacin E, Lycopene, Linolenic Acid, Oleic Acid, Vitamin C and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Gallic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lycopene can manipulate biochemical pathways Extracellular Matrix Remodelling. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Prostate Adenocarcinoma with chemotherapy Mitoxantrone – Foods like Pomegranate are recommended compared to Watermelon. This is because the active ingredients Lycopene and Vitamin A in Watermelon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER WATERMELON FOR PROSTATE ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY MITOXANTRONE FOR SOME CONDITIONS.
Eat more nuts, Walnut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Myricetin, Betulinic Acid, Beta-sitosterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Folic Acid, Lecithin and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling. Myricetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Focal Adhesion. And so on.
When treating Prostate Adenocarcinoma with chemotherapy Mitoxantrone – Foods like Walnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER BRAZIL NUT FOR PROSTATE ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY MITOXANTRONE FOR SOME CONDITIONS.
Foods for Genetic Risk of Prostate Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SPOP and PTEN are two genes whose abnormalities are risk factors for Prostate Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Prostate Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Prostate Adenocarcinoma gene SPOP has causative impact on biological pathways like . And PTEN has a causative impact on biological pathways like Autophagy and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SPOP and PTEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SPOP and PTEN should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Beta-sitosterol, Vitamin E, Daidzein, Caffeic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Prostate Adenocarcinoma due to abnormalities in genes SPOP and PTEN – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PROSTATE ADENOCARCINOMA DUE TO GENES SPOP AND PTEN
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Vitamin C, Quercetin, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Prostate Adenocarcinoma due to abnormalities in genes SPOP and PTEN – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF PROSTATE ADENOCARCINOMA DUE TO GENES SPOP AND PTEN
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Huckleberry?
The active ingredients contained in Orange are D-limonene, Linalool, Oleic Acid, Hesperidin, Vitamin C among others. While the active ingredients contained in Huckleberry are Resveratrol, Caffeic Acid, Vitamin C, Quercetin, P-coumaric Acid and others.
D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Prostate Adenocarcinoma due to abnormalities in genes SPOP and PTEN – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF PROSTATE ADENOCARCINOMA DUE TO GENES SPOP AND PTEN
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin E, Oleic Acid, Vitamin C, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Prostate Adenocarcinoma due to abnormalities in genes SPOP and PTEN – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF PROSTATE ADENOCARCINOMA DUE TO GENES SPOP AND PTEN
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Prostate Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Prostate Dkfz 2018
- Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
- Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- d -Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Research progress on the anticancer effects of vitamin K2.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.