Which Foods are Recommended for Pleomorphic Xanthoastrocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pleomorphic Xanthoastrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pleomorphic Xanthoastrocytoma because of DCLRE1C and SLX4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pleomorphic Xanthoastrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Watermelon” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Green Bean” or “Can I take St. John’s Wort and Quercetin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PLEOMORPHIC XANTHOASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pleomorphic Xanthoastrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PLEOMORPHIC XANTHOASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pleomorphic Xanthoastrocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pleomorphic Xanthoastrocytoma from cBioPortal. The patients enrolled in the studies for Pleomorphic Xanthoastrocytoma are in ages between 70 to 70 with an average age of 70.From a patient sample size of 1; the top genes with mutations and other abnormalities for Pleomorphic Xanthoastrocytoma include genes BRAF, DCLRE1C, SLX4, CIITA and RAD54B. The occurrence frequency distribution for these genes respectively is 77.8%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Pleomorphic Xanthoastrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pleomorphic Xanthoastrocytoma.

Pleomorphic xanthoastrocytoma (PXA) is a slow growing, rare tumor of the central nervous system that develops in the brain or spinal cord. It is classified as a low-grade (WHO grade 2) astrocytic tumor and is characterized by its pleomorphic (varied) appearance under the microscope as a fluid-filled cyst within solid tissue. PXA can form in one of the four lobes of the brain, but the temporal lobe is the most common location for this tumor. The pathology of PXA is complex, and the exact molecular mechanisms behind its development are not fully understood. Nevertheless, recent advancements in molecular studies have revealed that genetic mutations and alterations play a role in the development of PXA. Symptoms of PXA include seizures, epilepsy and chronic headaches. These pleomorphic xanthoastrocytomas can occur at any age but tend to occur more often in younger adults and slightly more often in males than females. The treatment of PXA typically involves surgical removal of the tumor, with the goal of achieving complete removal. In some cases of recurrence of the tumor, additional treatments such as radiation therapy, chemotherapy or targeted treatment may also be recommended. The outcome for patients with PXA is generally good, especially with early diagnosis and appropriate treatment. The 5-year survival rate for individuals diagnosed with PXA is over 75%. Additionally, supportive care with optimal nutrition (foods and natural supplements) can help improve the patient’s well-being. (Ref: https://www.cancer.gov/rare-brain-spine-tumor/tumors/pleomorphic-xanthroastrocytoma; https://www.futuremedicine.com/doi/10.2217/cns-2019-0009; https://link.springer.com/article/10.1007/s11547-022-01531-3 )

Significance of Nutrition for Pleomorphic Xanthoastrocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pleomorphic Xanthoastrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Watermelon includes active ingredients Lycopene, Cucurbitacin E, Linolenic Acid, Vitamin C, Oleic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pleomorphic Xanthoastrocytoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pleomorphic Xanthoastrocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PLEOMORPHIC XANTHOASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pleomorphic Xanthoastrocytoma undergoing chemotherapy treatment

In Pleomorphic Xanthoastrocytoma – the genes BRAF, DCLRE1C, SLX4, CIITA and RAD54B have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pleomorphic Xanthoastrocytoma are RAS-RAF Signaling, Cell Cycle, Extracellular Matrix Remodelling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Kaempferol, Daidzein, Lupeol, Beta-sitosterol, Delphinidin among others. While the active ingredients contained in Common Bean are Apigenin, Kaempferol, P-coumaric Acid, Delphinidin, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and DNA Repair. And so on.

When treating Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Green Bean?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Chlorogenic Acid, Beta-carotene, Vitamin C, Protocatechuic Acid among others. While the active ingredients contained in Green Bean are Kaempferol, Beta-sitosterol, Linolenic Acid, Vitamin C, Ferulic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. Chlorogenic Acid has biological action on biochemical pathways JAK-STAT Signaling, Notch Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Astragalin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Green Bean. This is because the active ingredients Vitamin A and Astragalin in Green Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Chlorogenic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER GREEN BEAN FOR PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Rowanberry or Watermelon?

Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Watermelon are Lycopene, Cucurbitacin E, Linolenic Acid, Vitamin C, Oleic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and DNA Repair.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

When treating Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Rowanberry are recommended compared to Watermelon. This is because the active ingredients Lycopene and Vitamin A in Watermelon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER WATERMELON FOR PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Resveratrol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Salicylic Acid, Linolenic Acid, Vitamin B3, Gamma-linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin E has biological action on biochemical pathways DNA Repair, Notch Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways NFKB Signaling. And so on.

When treating Pleomorphic Xanthoastrocytoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PUMPKIN SEEDS FOR PLEOMORPHIC XANTHOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Pleomorphic Xanthoastrocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DCLRE1C and SLX4 are two genes whose abnormalities are risk factors for Pleomorphic Xanthoastrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pleomorphic Xanthoastrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pleomorphic Xanthoastrocytoma gene DCLRE1C has causative impact on biological pathways like DNA Repair and DNA Repair. And SLX4 has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DCLRE1C and SLX4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DCLRE1C and SLX4 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Vitamin C, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Apoptosis, RAS-RAF Signaling and MYC Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Pleomorphic Xanthoastrocytoma due to abnormalities in genes DCLRE1C and SLX4 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES DCLRE1C AND SLX4

Eat more vegetables, Cassava or Bell Pepper?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, Capsaicin, Linolenic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Capsaicin can manipulate biochemical pathways Small Molecule Transport. Dihydrocapsaicin has biological action on biochemical pathways Small Molecule Transport. And so on.

For genetic risk of Pleomorphic Xanthoastrocytoma due to abnormalities in genes DCLRE1C and SLX4 – Foods like Cassava are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Dihydrocapsaicin in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES DCLRE1C AND SLX4

Eat more fruits, Feijoa or Strawberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Casuarinin has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Pleomorphic Xanthoastrocytoma due to abnormalities in genes DCLRE1C and SLX4 – Foods like Feijoa are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES DCLRE1C AND SLX4

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Macadamia Nut are Palmitic Acid, Beta-sitosterol, Lauric Acid, Folic Acid, Myristic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Small Molecule Transport, Cell Cycle Checkpoints and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Small Molecule Transport, DNA Repair and Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Pleomorphic Xanthoastrocytoma due to abnormalities in genes DCLRE1C and SLX4 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC XANTHOASTROCYTOMA DUE TO GENES DCLRE1C AND SLX4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pleomorphic Xanthoastrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Glioma Mskcc 2019
• Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Chlorogenic-induced inhibition of non-small cancer cells occurs through regulation of histone deacetylase 6.
• Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.
• Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• Clinical pharmacodynamics of antihistamines.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Fisetin: a dietary antioxidant for health promotion.