Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Oropharyngeal Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Oropharyngeal Cancer because of TOP2A and EP300 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Oropharyngeal Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Lycopene and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OROPHARYNGEAL CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Oropharyngeal Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR OROPHARYNGEAL CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Oropharyngeal Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Oropharyngeal Cancer from cBioPortal. The top genes with mutations and other abnormalities for Oropharyngeal Cancer include genes TP53, PIK3CA, KMT2D, TOP2A and EP300. The occurrence frequency distribution for these genes respectively is 26.3%, 20.6%, 16.0%, 14.3% and 11.6%. These tumor genetic details of Oropharyngeal Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Oropharyngeal Cancer.
Significance of Nutrition for Oropharyngeal Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Oropharyngeal Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Gooseberry includes active ingredients Beta-sitosterol, Linolenic Acid, Modified Citrus Pectin, Vitamin C, Gallic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Oropharyngeal Cancer, activation or inhibition of selected biochemical pathways like Apoptosis, Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Oropharyngeal Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OROPHARYNGEAL CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Oropharyngeal Cancer undergoing chemotherapy treatment
In Oropharyngeal Cancer – the genes TP53, PIK3CA, KMT2D, TOP2A and EP300 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Oropharyngeal Cancer are Apoptosis, Extracellular Matrix Remodelling, Nutrient sensing and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Extracellular Matrix Remodelling, Nutrient sensing so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, Growth Factor Signaling and Cell Cycle.
Genistein can manipulate biochemical pathways Nutrient sensing. Vitamin A has biological action on biochemical pathways NFKB Signaling and TGFB Signaling. And so on.
When treating Oropharyngeal Cancer with chemotherapy Docetaxel – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR OROPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Carob?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Brassinin, Indole-3-carbinol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Phloroglucinol, Gallic Acid, Palmitic Acid and others.
Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, Growth Factor Signaling and Cell Cycle.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, Growth Factor Signaling and JAK-STAT Signaling. And so on.
When treating Oropharyngeal Cancer with chemotherapy Docetaxel – Foods like Kohlrabi are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER CAROB FOR OROPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Gooseberry?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Gooseberry are Beta-sitosterol, Linolenic Acid, Modified Citrus Pectin, Vitamin C, Gallic Acid and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Extracellular Matrix Remodelling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Microtubule Dynamics.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Microtubule Dynamics. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Extracellular Matrix Remodelling. And so on.
When treating Oropharyngeal Cancer with chemotherapy Docetaxel – Foods like Partridgeberry are recommended compared to Gooseberry. This is because the active ingredients Rutin and Oleic Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER GOOSEBERRY FOR OROPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways NFKB Signaling and TGFB Signaling. Lecithin has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Oropharyngeal Cancer with chemotherapy Docetaxel – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR OROPHARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Foods for Genetic Risk of Oropharyngeal Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TOP2A and EP300 are two genes whose abnormalities are risk factors for Oropharyngeal Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Oropharyngeal Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Oropharyngeal Cancer gene TOP2A has causative impact on biological pathways like Cell Cycle, Cell Cycle and Post Translation Modification. And EP300 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and Immune Evasion Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TOP2A and EP300 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TOP2A and EP300 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Kaempferol, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Linolenic Acid, Daidzein, Vitamin E and others.
Quercetin can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Oropharyngeal Cancer due to abnormalities in genes TOP2A and EP300 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF OROPHARYNGEAL CANCER DUE TO GENES TOP2A AND EP300
Eat more vegetables, Sweet Potato or Celery?
The active ingredients contained in Sweet Potato are Quercetin, Salicylic Acid, Linolenic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Luteolin, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Luteolin can manipulate biochemical pathways MYC Signaling. Cynaroside has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Oropharyngeal Cancer due to abnormalities in genes TOP2A and EP300 – Foods like Sweet Potato are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Sweet Potato together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SWEET POTATO IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF OROPHARYNGEAL CANCER DUE TO GENES TOP2A AND EP300
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Apricot or Strawberry?
The active ingredients contained in Apricot are Quercetin, Salicylic Acid, Modified Citrus Pectin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Strawberry are Lupeol, Ellagic Acid, Salicylic Acid, Linolenic Acid, Oleic Acid and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Apoptosis. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Oropharyngeal Cancer due to abnormalities in genes TOP2A and EP300 – Foods like Apricot are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Quercetin contained in Apricot together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: APRICOT IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF OROPHARYNGEAL CANCER DUE TO GENES TOP2A AND EP300
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Salicylic Acid, Linolenic Acid, Vitamin E, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. And so on.
For genetic risk of Oropharyngeal Cancer due to abnormalities in genes TOP2A and EP300 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF OROPHARYNGEAL CANCER DUE TO GENES TOP2A AND EP300
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Oropharyngeal Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.