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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Non-seminomatous Germ Cell Tumor?

Aug 17, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Non-seminomatous Germ Cell Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Non-seminomatous Germ Cell Tumor because of KIT and ROS1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Non-seminomatous Germ Cell Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Garland Chrysanthemum” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO NON-SEMINOMATOUS GERM CELL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Non-seminomatous Germ Cell Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR NON-SEMINOMATOUS GERM CELL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Non-seminomatous Germ Cell Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Non-seminomatous Germ Cell Tumor from cBioPortal. The patients enrolled in the studies for Non-seminomatous Germ Cell Tumor are in ages between 16 to 58 with an average age of 28.From a patient sample size of 137; the top genes with mutations and other abnormalities for Non-seminomatous Germ Cell Tumor include genes KIT, ROS1, CREBBP, RAC1 and EPHA3. The occurrence frequency distribution for these genes respectively is 8.9%, 6.7%, 6.7%, 6.7% and 4.4%. These tumor genetic details of Non-seminomatous Germ Cell Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Non-seminomatous Germ Cell Tumor.

Significance of Nutrition for Non-seminomatous Germ Cell Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Non-seminomatous Germ Cell Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Bilberry includes active ingredients Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Non-seminomatous Germ Cell Tumor, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Non-seminomatous Germ Cell Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Non-seminomatous Germ Cell Tumor, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR NON-SEMINOMATOUS GERM CELL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Non-seminomatous Germ Cell Tumor undergoing chemotherapy treatment

In Non-seminomatous Germ Cell Tumor – the genes KIT, ROS1, CREBBP, RAC1 and EPHA3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Non-seminomatous Germ Cell Tumor are Cell Cycle, C-type Lectin Receptor Signaling, Cell Cycle Checkpoints and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Linoleic Acid, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Non-seminomatous Germ Cell Tumor with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR NON-SEMINOMATOUS GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Garland Chrysanthemum?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Beta-carotene, Vitamin C, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Garland Chrysanthemum are Vitamin C, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Non-seminomatous Germ Cell Tumor with chemotherapy Cisplatin – Foods like Jicama are recommended compared to Garland Chrysanthemum. This is because the active ingredients Vitamin A and Folic Acid in Garland Chrysanthemum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR NON-SEMINOMATOUS GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Non seminomatous Germ Cell Tumor?

Eat more fruits, Feijoa or Bilberry?

Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Arbutin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Non-seminomatous Germ Cell Tumor with chemotherapy Cisplatin – Foods like Feijoa are recommended compared to Bilberry. This is because the active ingredients Arbutin and Chlorogenic Acid in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER BILBERRY FOR NON-SEMINOMATOUS GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Walnut are Quercetin, D-limonene, Betulinic Acid, Beta-sitosterol, Vitamin E and others.

Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways DNA Repair, Cell Cycle and Cell Survival.

D-limonene can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

When treating Non-seminomatous Germ Cell Tumor with chemotherapy Cisplatin – Foods like Hazelnut are recommended compared to Walnut. This is because the active ingredients D-limonene and Ellagic Acid in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER WALNUT FOR NON-SEMINOMATOUS GERM CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Non-seminomatous Germ Cell Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KIT and ROS1 are two genes whose abnormalities are risk factors for Non-seminomatous Germ Cell Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Non-seminomatous Germ Cell Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Non-seminomatous Germ Cell Tumor gene KIT has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And ROS1 has a causative impact on biological pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KIT and ROS1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KIT and ROS1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin E, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-seminomatous Germ Cell Tumor due to abnormalities in genes KIT and ROS1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF NON-SEMINOMATOUS GERM CELL TUMOR DUE TO GENES KIT AND ROS1

Eat more vegetables, Cassava or Jute?

The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin B3 and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-seminomatous Germ Cell Tumor due to abnormalities in genes KIT and ROS1 – Foods like Cassava are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Vitamin A in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF NON-SEMINOMATOUS GERM CELL TUMOR DUE TO GENES KIT AND ROS1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Huckleberry?

The active ingredients contained in Kiwi are Quercetin, Vitamin C, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Ferulic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways EPHRIN Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-seminomatous Germ Cell Tumor due to abnormalities in genes KIT and ROS1 – Foods like Kiwi are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF NON-SEMINOMATOUS GERM CELL TUMOR DUE TO GENES KIT AND ROS1

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-seminomatous Germ Cell Tumor due to abnormalities in genes KIT and ROS1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF NON-SEMINOMATOUS GERM CELL TUMOR DUE TO GENES KIT AND ROS1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Non-seminomatous Germ Cell Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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