Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mucinous Stomach Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mucinous Stomach Adenocarcinoma because of GRIN3A and NCOA3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mucinous Stomach Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Gooseberry in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Curcumin and Andrographis supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MUCINOUS STOMACH ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mucinous Stomach Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MUCINOUS STOMACH ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mucinous Stomach Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mucinous Stomach Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Mucinous Stomach Adenocarcinoma are in ages between 52 to 74 with an average age of 65. 83.3% of males and 16.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 6; the top genes with mutations and other abnormalities for Mucinous Stomach Adenocarcinoma include genes GRIN3A, NCOA3, TP53, EPHA3 and MPL. The occurrence frequency distribution for these genes respectively is 40.0%, 40.0%, 40.0%, 20.0% and 20.0%. These tumor genetic details of Mucinous Stomach Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mucinous Stomach Adenocarcinoma.
Significance of Nutrition for Mucinous Stomach Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mucinous Stomach Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Naringin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others. And Gooseberry contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mucinous Stomach Adenocarcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Interferon Signaling, Cell Cycle, G-protein-coupled Receptor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mucinous Stomach Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MUCINOUS STOMACH ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mucinous Stomach Adenocarcinoma undergoing chemotherapy treatment
In Mucinous Stomach Adenocarcinoma – the genes GRIN3A, NCOA3, TP53, EPHA3 and MPL have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mucinous Stomach Adenocarcinoma are Angiogenesis, Interferon Signaling, DNA Repair and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Interferon Signaling, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Cianidanol, Butyric Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Angiogenesis. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways Interferon Signaling. Palmitic Acid has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Mucinous Stomach Adenocarcinoma with chemotherapy Pembrolizumab – Foods like Scarlet Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Vitamin A and Palmitic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR MUCINOUS STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Carrot or Okra?
Vegetables are an important part of many diets. The active ingredients contained in Carrot are Beta-carotene, Vitamin E, Lupeol, Lycopene, Quercetin among others. While the active ingredients contained in Okra are Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Beta-carotene can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and DNA Repair. Beta-cryptoxanthin has biological action on biochemical pathways Angiogenesis, Interferon Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways Interferon Signaling. Quercetin has biological action on biochemical pathways Interferon Signaling. And so on.
When treating Mucinous Stomach Adenocarcinoma with chemotherapy Pembrolizumab – Foods like Carrot are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Beta-cryptoxanthin contained in Carrot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CARROT IS RECOMMENDED OVER OKRA FOR MUCINOUS STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Gooseberry or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Gooseberry are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Angiogenesis. Gallic Acid has biological action on biochemical pathways DNA Repair, MYC Signaling and Angiogenesis.
Naringenin can manipulate biochemical pathways Interferon Signaling. Naringetol has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Mucinous Stomach Adenocarcinoma with chemotherapy Pembrolizumab – Foods like Gooseberry are recommended compared to Pummelo. This is because the active ingredients Naringenin and Naringetol in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Gallic Acid contained in Gooseberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GOOSEBERRY IS RECOMMENDED OVER PUMMELO FOR MUCINOUS STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Acorn are Beta-carotene, Quercetin, Vitamin C, Beta-sitosterol, Vitamin B3 and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, DNA Repair and Angiogenesis. Cianidanol has biological action on biochemical pathways MYC Signaling and Angiogenesis.
Quercetin can manipulate biochemical pathways Interferon Signaling. Quercitrin has biological action on biochemical pathways Interferon Signaling. And so on.
When treating Mucinous Stomach Adenocarcinoma with chemotherapy Pembrolizumab – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Quercitrin in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR MUCINOUS STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Mucinous Stomach Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GRIN3A and NCOA3 are two genes whose abnormalities are risk factors for Mucinous Stomach Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mucinous Stomach Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mucinous Stomach Adenocarcinoma gene GRIN3A has causative impact on biological pathways like G-protein-coupled Receptor Signaling. And NCOA3 has a causative impact on biological pathways like Androgen Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GRIN3A and NCOA3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GRIN3A and NCOA3 should be avoided.
Eat more pulses, Mung Bean or Fava Bean?
The active ingredients contained in Mung Bean are Genistein, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Genistein, Daidzein, Quercetin, Vitamin C, Beta-sitosterol and others.
Genistein can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Growth Factor Signaling.
Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling and Growth Factor Signaling. And so on.
For genetic risk of Mucinous Stomach Adenocarcinoma due to abnormalities in genes GRIN3A and NCOA3 – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Genistein and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF MUCINOUS STOMACH ADENOCARCINOMA DUE TO GENES GRIN3A AND NCOA3
Eat more vegetables, Jicama or Chicory?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Lupeol, Quercetin, Esculin, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and Cell Cycle Checkpoints. Beta-carotene has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Cell Cycle.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mucinous Stomach Adenocarcinoma due to abnormalities in genes GRIN3A and NCOA3 – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Linoleic Acid and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF MUCINOUS STOMACH ADENOCARCINOMA DUE TO GENES GRIN3A AND NCOA3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Vitamin C, Resveratrol, Delphinidin, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and Cell Cycle.
Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mucinous Stomach Adenocarcinoma due to abnormalities in genes GRIN3A and NCOA3 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Ferulic Acid and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF MUCINOUS STOMACH ADENOCARCINOMA DUE TO GENES GRIN3A AND NCOA3
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Vitamin C, Beta-sitosterol, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Mucinous Stomach Adenocarcinoma due to abnormalities in genes GRIN3A and NCOA3 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MUCINOUS STOMACH ADENOCARCINOMA DUE TO GENES GRIN3A AND NCOA3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mucinous Stomach Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Tmb Mskcc 2018
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- Characterization of the endocoid for imipramine recognition sites.
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- Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene.
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- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Quercitrin ameliorates the development of systemic lupus erythematosus-like disease in a chronic graft-versus-host murine model.
- Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
- Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.
- New concepts in phospholipase D signaling in inflammation and cancer.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.